As soon as blood leaves the human body, stress to the host´s protective cellular and protein cascades begin. My thesis focuses on the immune system, specifically the complement system and platelets, primarily known for their hemostatic properties but also play a role in immune responses. The core of this thesis is the interaction between the complement system and platelets in platelet concentrates destined for transfusion. Storing blood products, particularly platelet concentrates, presents challenges, including the development of platelet storage lesions. These lesions involve a series of biochemical, structural, and functional changes from when platelets are collected to when they are transfused, potentially leading to impaired platelet function and adverse transfusion reactions. For inventory management, the oldest platelet concentrates are typically used first for transfusion. Understanding the interplay between the complement system and platelets during storage is crucial for improving the quality of platelet concentrates for selecting optimal concentrates based on the indication. This thesis includes several exploratory studies: one examining the complement system and platelet function over storage time, another investigating the impact of complement inhibition with the aim to reduce platelet storage lesions, and a third exploring the ability of platelets to release mediators that can modulate an immune response when supplemented to thrombocytopenic blood. Additionally, one study examines the impact of blood collection tube composition on complement functional and activation analysis. I found that increased storage time was associated with increased complement activation, increased platelet activation and attenuated platelet function. However, there was no causal relationship between complement and platelet activation since complement inhibition did not alter platelet activation or function. Further, I found that platelets release mediators that could modulate an inflammatory reaction, but the storage time had only minor effect on the immunomodulatory effect. Last, I found that the composition of blood collection tubes significantly affected complement activation. While these findings may not immediately benefit patients, they provide new insights into platelet concentrates, highlighting the role of the complement system. Further research is needed to to understand the interaction between these components fully.

This doctoral thesis examines the challenges and potential improvements in managing archaeological projects related to the Sámi people in Sweden. The focus is on aligning practices of contract archaeology with national and international policies for managing Indigenous cultural heritage. The research identifies five key challenges in Swedish archaeology: defining Sámi heritage sites, determining responsibility for relevant expertise, managing Sámi-related information, establishing processes of contract archaeology acceptable to all stakeholders, and deciding whether Sámi and "Swedish" heritage should be managed together or separately. The study compares the approach in Sweden with practices in Norway and British Columbia, Canada, to explore potential solutions. Different systems for cultural heritage management are analysed alongside interviews with archaeologists, Indigenous community members, officials, and other stakeholders, to map success factors and pitfalls of Indigenous cultural heritage management. The study highlights the slow implementation of the United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP) in Sweden and the lack of legislation ensuring Sámi involvement in archaeological projects. The research suggests that addressing these challenges will require re-evaluating current practices, including developing clearer guidelines for managing Sámi heritage sites, improving collaboration between archaeologists and Sámi communities, finding ways to include intangible aspects of cultural heritage within cultural heritage management, and potentially delegating more authority in cultural heritage management to the Sámi Parliament. The thesis concludes by proposing strategies to better align Swedish contract archaeology with national and international policies on Indigenous cultural heritage, emphasizing the need for a balanced approach that respects Indigenous rights while addressing concerns in archaeological practice. These recommendations aim to ensure that Sámi cultural heritage is managed respectfully, acknowledging its unique history and perspectives, while facilitating effective collaboration among all stakeholders involved in archaeological projects.

In Sweden, the opportunities for the public to participate practically in archaeological work are few, even though there is a great interest among many members of society in devoting themselves to this. This doctoral thesis explores some of the few Swedish archaeological projects that are conducted together with the public, but also looks at similar projects or activities that are performed in other countries. The study examines which values and effects arise when people outside the profession are allowed to participate in archaeological work and which factors affect the possibilities of conducting archaeological projects based on public participation. I have chosen to call the project form Participatory Archaeology. 

To understand the effects that arise and how different factors interact, the research has been directed backward in time to explain the current situation, inwards towards the projects to understand the actors' experiences, and outwards towards other countries to understand which factors affect the operation of the type of business. The purpose of the latter is to identify factors that may be worth considering in a work of change where practical archeology in Sweden can become accessible to more people. The study also includes a separate research project that investigates how different sociological methods and models can be used to develop an activity toward a higher degree of participation and involvement.

The study has shown that the project type can generate several different kinds of values, both for the actors involved and for archaeological science. The study has also shown that there are many different factors that can hinder or improve the possibilities for conducting archaeological projects together with the public. In order to create a future where Participatory Archeology is more common, these factors need to be taken into account. The aim of the study is that the results can partly be used in the initiation and design of similar collaborative projects, partly to initiate a discussion, and subsequently a strategy, for how we can in the future develop a cultural environment work and archeology that is accessible to more people in Sweden.

A further objective, common to all research projects within GRASCA, is to investigate the possibilities for both governmental and private archaeological actors to expand their activities in this area.