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Andersson, Håkan S.ORCID iD iconorcid.org/0000-0003-1241-8888
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Strand, M., Norenburg, J., Alfaya, J. E., Angel Fernandez-Alvarez, F., Andersson, H. S., Andrade, S. C. S., . . . Xu, C.-M. (2019). Nemertean taxonomy-Implementing changes in the higher ranks, dismissing Anopla and Enopla [Letter to the editor]. Zoologica Scripta, 48(1), 118-119
Öppna denna publikation i ny flik eller fönster >>Nemertean taxonomy-Implementing changes in the higher ranks, dismissing Anopla and Enopla
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2019 (Engelska)Ingår i: Zoologica Scripta, ISSN 0300-3256, E-ISSN 1463-6409, Vol. 48, nr 1, s. 118-119Artikel i tidskrift, Letter (Refereegranskat) Published
Ort, förlag, år, upplaga, sidor
Wiley-Blackwell, 2019
Nyckelord
nemertea, anopla, enopla, pilidiophora, hoplonemertea, palaeonemertea
Nationell ämneskategori
Zoologi Biologisk systematik
Forskningsämne
Naturvetenskap
Identifikatorer
urn:nbn:se:lnu:diva-79738 (URN)10.1111/zsc.12317 (DOI)000454505800010 ()2-s2.0-85055714721 (Scopus ID)
Tillgänglig från: 2019-01-23 Skapad: 2019-01-23 Senast uppdaterad: 2019-08-29Bibliografiskt granskad
Göransson, U., Jacobsson, E., Strand, M. & Andersson, H. S. (2019). The toxins of nemertean worms. Toxins, 11(2), 1-36, Article ID 120.
Öppna denna publikation i ny flik eller fönster >>The toxins of nemertean worms
2019 (Engelska)Ingår i: Toxins, ISSN 2072-6651, E-ISSN 2072-6651, Vol. 11, nr 2, s. 1-36, artikel-id 120Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Most ribbon worms (phylum: Nemertea) are found in marine environments, where they act as predators and scavengers. They are characterized by an eversible proboscis that is used to hunt for prey and thick mucus covering their skin. Both proboscis and epidermal mucus mediate toxicity to predators and preys. Research into the chemical nature of the substances that render toxicity has not been extensive, but it has nevertheless led to the identification of several compounds of potential medicinal use or for application in biotechnology. This review provides a complete account of the current status of research into nemertean toxins.

Ort, förlag, år, upplaga, sidor
MDPI, 2019
Nyckelord
Anabaseine, cytotoxin, DMXBA, nemertea, nemertide, parborlysin, ribbon worm, tetrodotoxin
Nationell ämneskategori
Farmakologi och toxikologi
Forskningsämne
Biomedicinsk vetenskap, Farmakologi; Naturvetenskap, Cell- och organismbiologi; Biomedicinsk vetenskap, Farmakologi; Kemi, Biokemi
Identifikatorer
urn:nbn:se:lnu:diva-80740 (URN)10.3390/toxins11020120 (DOI)000460801500062 ()30781381 (PubMedID)2-s2.0-85061849853 (Scopus ID)
Forskningsfinansiär
Vetenskapsrådet, 214-3327Forskningsrådet Formas, 2018-00613Crafoordska stiftelsen, 20160810Vetenskapsrådet, 2018-005403
Tillgänglig från: 2019-02-21 Skapad: 2019-02-21 Senast uppdaterad: 2019-08-29Bibliografiskt granskad
Andersson, H. S., Jacobsson, E., Laborde, Q., Rosengren, J., Strand, M. & Göransson, U. (2018). Alpha-nemertides - a novel family of nemertean peptide neurotoxins. In: : . Paper presented at 9th International Conference on nemertean biology, List auf Sylt, Germany, August 13-17, 2018 (pp. 2).
Öppna denna publikation i ny flik eller fönster >>Alpha-nemertides - a novel family of nemertean peptide neurotoxins
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2018 (Engelska)Konferensbidrag, Muntlig presentation med publicerat abstract (Övrigt vetenskapligt)
Abstract [en]

We recently discovered a novel family of neuroactive peptides in nemerteans, which we have named alpha-nemertides (1). One of these peptides, nemertide alpha-1, has been the subject of detailed studies with regard to structure and effects. The peptide exhibits exceptional potency against a number of arthropod species. Moreover, in vitro experiments suggest that alpha-1 acts primarily on voltage-gated sodium channels, and that this action is selective for arthropods by two orders of magnitude over vertebrate species. Using transcriptomic and proteomic approaches, we have identified 10 alpha-nemertides, but this number is likely to increase. These peptides alongside with a series of mutants are currently under evaluation by our group, with the goal to improve our understanding of structure-function relationships. In addition, we are considering potential practical uses of alpha-nemertides. In this talk, I will describe the current status of this research project.

1. E. Jacobsson et al., Peptide ion channel toxins from the bootlace worm, the longest animal on Earth. Scientific reports 8, 4596 (2018).

Nationell ämneskategori
Biokemi och molekylärbiologi
Forskningsämne
Kemi, Medicinsk kemi
Identifikatorer
urn:nbn:se:lnu:diva-77432 (URN)
Konferens
9th International Conference on nemertean biology, List auf Sylt, Germany, August 13-17, 2018
Forskningsfinansiär
Vetenskapsrådet, 214-3327
Tillgänglig från: 2018-08-28 Skapad: 2018-08-28 Senast uppdaterad: 2019-02-22Bibliografiskt granskad
Helin, A. S., Aarts, L., Bususu, I., Andersson, H. S., Rosengren, J., Chapman, J. R. & Waldenström, J. (2018). Antimicrobial differences between AvBDs in mallards (Anas platyrhynchos). In: : . Paper presented at IMAP 2018: 8th International Meeting on Antimicrobial Peptides, Sep 2-4, 2018. Edinburgh, Scotland..
Öppna denna publikation i ny flik eller fönster >>Antimicrobial differences between AvBDs in mallards (Anas platyrhynchos)
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2018 (Engelska)Konferensbidrag, Poster (med eller utan abstract) (Övrigt vetenskapligt)
Nationell ämneskategori
Evolutionsbiologi
Forskningsämne
Ekologi, Evolutionsbiologi
Identifikatorer
urn:nbn:se:lnu:diva-77430 (URN)
Konferens
IMAP 2018: 8th International Meeting on Antimicrobial Peptides, Sep 2-4, 2018. Edinburgh, Scotland.
Anmärkning

Ej belagd 20190222

Tillgänglig från: 2018-08-28 Skapad: 2018-08-28 Senast uppdaterad: 2019-02-22Bibliografiskt granskad
Andersson, H. S., Jacobsson, E., Rosengren, J., Strand, M. & Göransson, U. (2018). Mapping the diversity of nemertean peptide toxins. In: : . Paper presented at 9th International Conference on nemertean biology, List auf Sylt, Germany, August 13-17, 2018.
Öppna denna publikation i ny flik eller fönster >>Mapping the diversity of nemertean peptide toxins
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2018 (Engelska)Konferensbidrag, Poster (med eller utan abstract) (Övrigt vetenskapligt)
Nationell ämneskategori
Biokemi och molekylärbiologi
Forskningsämne
Naturvetenskap, Biomedicinsk vetenskap
Identifikatorer
urn:nbn:se:lnu:diva-77431 (URN)
Konferens
9th International Conference on nemertean biology, List auf Sylt, Germany, August 13-17, 2018
Forskningsfinansiär
Vetenskapsrådet, 214-3327
Anmärkning

Ej belagd 20190222

Tillgänglig från: 2018-08-28 Skapad: 2018-08-28 Senast uppdaterad: 2019-02-22Bibliografiskt granskad
Jacobsson, E., Andersson, H. S., Strand, M., Peigneur, S., Eriksson, C., Loden, H., . . . Göransson, U. (2018). Peptide ion channel toxins from the bootlace worm, the longest animal on Earth. Scientific Reports, 8, Article ID 4596.
Öppna denna publikation i ny flik eller fönster >>Peptide ion channel toxins from the bootlace worm, the longest animal on Earth
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2018 (Engelska)Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikel-id 4596Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Polypeptides from animal venoms have found important uses as drugs, pharmacological tools, and within biotechnological and agricultural applications. We here report a novel family of cystine knot peptides from nemertean worms, with potent activity on voltage-gated sodium channels. These toxins, named the alpha-nemertides, were discovered in the epidermal mucus of Lineus longissimus, the 'bootlace worm' known as the longest animal on earth. The most abundant peptide, the 31-residue long alpha-1, was isolated, synthesized, and its 3D NMR structure determined. Transcriptome analysis including 17 species revealed eight alpha-nemertides, mainly distributed in the genus Lineus. alpha-1 caused paralysis and death in green crabs (Carcinus maenas) at 1 mu g/kg (similar to 300 pmol/kg). It showed profound effect on invertebrate voltage-gated sodium channels (e.g. Blattella germanica Na(v)1) at low nanomolar concentrations. Strong selectivity for insect over human sodium channels indicates that a-nemertides can be promising candidates for development of bioinsecticidal agents.

Ort, förlag, år, upplaga, sidor
Nature Publishing Group, 2018
Nyckelord
ribbon worms, nemertea, peptide toxin, sodium channel, insecticide
Nationell ämneskategori
Biokemi och molekylärbiologi
Forskningsämne
Naturvetenskap, Biomedicinsk vetenskap
Identifikatorer
urn:nbn:se:lnu:diva-72295 (URN)10.1038/s41598-018-22305-w (DOI)000428029600001 ()29567943 (PubMedID)2-s2.0-85044358780 (Scopus ID)
Forskningsfinansiär
Vetenskapsrådet, 2014-3327
Tillgänglig från: 2018-04-06 Skapad: 2018-04-06 Senast uppdaterad: 2019-08-29Bibliografiskt granskad
Nyberg, M., Olsson, V., Örtman, G., Pajalic, Z., Andersson, H. S., Blücher, A., . . . Westergren, A. (2018). The meal as a performance: food and meal practices beyond health and nutrition. Ageing & Society (1), 83-107
Öppna denna publikation i ny flik eller fönster >>The meal as a performance: food and meal practices beyond health and nutrition
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2018 (Engelska)Ingår i: Ageing & Society, ISSN 0144-686X, E-ISSN 1469-1779, nr 1, s. 83-107Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The proportion of elderly people in the population is increasing, presenting a number of new challenges in society. The purpose of this qualitative study was to in- vestigate how elderly persons with motoric eating difficulties perceive and perform their food and meal practices in everyday life. By using Goffman’s concept of performance as a theoretical framework together with Bourdieu’s thinking on habitus, a deeper understanding of food and meal practices is obtained. Semi- structured interviews were conducted with  elderly people (aged between  and  years) and meal observations were carried out with  of these people. Participants were found to manage food and meal practices by continuously adjust- ing and adapting to the new conditions arising as a result of eating difficulties. This was displayed by conscious planning of what to eat and when, avoiding certain foods and beverages, using simple eating aids, but also withdrawing socially during the meals. All these adjustments were important in order to be able to demonstrate proper food and meal behaviour, to maintain the façade and to act according to the perceived norms. As well as being a pleasurable event, food and meals were also perceived in terms of being important for maintaining health and as ‘fuel’ where the main purpose is to sustain life. This was strongly connected to the social context and the ability to enjoy food and meals with family members and friends, which appeared to be particularly crucial due to the impending risk of failing the meal performance. 

Ort, förlag, år, upplaga, sidor
Cambridge University Press, 2018
Nyckelord
elderly people, eating difficulties, food and meal practices, meals, independence, eating aids
Nationell ämneskategori
Näringslära
Forskningsämne
Samhällsvetenskap, Sociologi
Identifikatorer
urn:nbn:se:lnu:diva-56302 (URN)10.1017/S0144686X16000945 (DOI)000418332500005 ()2-s2.0-84984697558 (Scopus ID)
Tillgänglig från: 2016-09-02 Skapad: 2016-09-02 Senast uppdaterad: 2019-08-29Bibliografiskt granskad
Jönsson, B. (2018). Världens längsta djur gör gift. Kemivärlden Biotech/Kemisk tidskrift (3), 20-21
Öppna denna publikation i ny flik eller fönster >>Världens längsta djur gör gift
2018 (Svenska)Ingår i: Kemivärlden Biotech/Kemisk tidskrift, ISSN 1653-5596, nr 3, s. 20-21Artikel i tidskrift (Övrig (populärvetenskap, debatt, mm)) Published
Abstract [sv]

Världens längsta djur, slemmasken långsnöre, producerar nervgifter som kan döda både krabbor och kackerlackor.

Ort, förlag, år, upplaga, sidor
Lidingö: Mentor Communications, 2018
Nyckelord
nemertea, slemmask, alfa-nemertider, toxikologi
Nationell ämneskategori
Biokemi och molekylärbiologi
Forskningsämne
Kemi, Biokemi
Identifikatorer
urn:nbn:se:lnu:diva-74028 (URN)
Forskningsfinansiär
Vetenskapsrådet, 2014-3327Crafoordska stiftelsen, 20160810
Tillgänglig från: 2018-05-08 Skapad: 2018-05-08 Senast uppdaterad: 2018-11-02Bibliografiskt granskad
Andersson, H. S., Jacobsson, E., Strand, M., Peigneur, S., Lebbe, E., Rosengren, J., . . . Göransson, U. (2017). Alpha-nemertides, a novel family of marine peptide neurotoxins from ribbon worms. In: : . Paper presented at 10th European Conference on Marine Natural Products, September 3-7, 2017, Kolymbari, Crete, Greece.
Öppna denna publikation i ny flik eller fönster >>Alpha-nemertides, a novel family of marine peptide neurotoxins from ribbon worms
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2017 (Engelska)Konferensbidrag, Muntlig presentation med publicerat abstract (Övrigt vetenskapligt)
Nationell ämneskategori
Biokemi och molekylärbiologi
Forskningsämne
Kemi, Medicinsk kemi
Identifikatorer
urn:nbn:se:lnu:diva-71390 (URN)
Konferens
10th European Conference on Marine Natural Products, September 3-7, 2017, Kolymbari, Crete, Greece
Anmärkning

Ej belagd 20180306

Tillgänglig från: 2018-03-05 Skapad: 2018-03-05 Senast uppdaterad: 2018-11-02Bibliografiskt granskad
Helin, A. S., Aarts, L., Bususu, I., Andersson, H. S., Rosengren, J., Chapman, J. R. & Waldenström, J. (2017). Antimicrobial activity differences in reduced vs. oxidized AvBD3b peptides in mallards (Anas platyrhynchos).. In: : . Paper presented at 7th International Meeting on Antimicrobia Peptides, 2017, August 25-27, Copenhagen, Denmark.
Öppna denna publikation i ny flik eller fönster >>Antimicrobial activity differences in reduced vs. oxidized AvBD3b peptides in mallards (Anas platyrhynchos).
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2017 (Engelska)Konferensbidrag, Poster (med eller utan abstract) (Övrigt vetenskapligt)
Nationell ämneskategori
Evolutionsbiologi
Forskningsämne
Naturvetenskap, Ekologi
Identifikatorer
urn:nbn:se:lnu:diva-71389 (URN)
Konferens
7th International Meeting on Antimicrobia Peptides, 2017, August 25-27, Copenhagen, Denmark
Tillgänglig från: 2018-03-05 Skapad: 2018-03-05 Senast uppdaterad: 2018-11-02Bibliografiskt granskad
Organisationer
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0003-1241-8888

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