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Bergman, P. (2018). The number of repeated observations needed to estimate the habitual physical activity of an individual to a given level of precision.. PLoS ONE, 13(2), Article ID e0192117.
Open this publication in new window or tab >>The number of repeated observations needed to estimate the habitual physical activity of an individual to a given level of precision.
2018 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 2, article id e0192117Article in journal (Refereed) Published
Abstract [en]

Physical activity behavior varies naturally from day to day, from week to week and even across seasons. In order to assess the habitual level of physical activity of a person, the person must be monitored for long enough so that the level can be identified, taking into account this natural within-person variation. An important question, and one whose answer has implications for study- and survey design, epidemiological research and population surveillance, is, for how long does an individual need to be monitored before such a habitual level or pattern can be identified to a desired level of precision? The aim of this study was to estimate the number of repeated observations needed to identify the habitual physical activity behaviour of an individual to a given degree of precision. A convenience sample of 50 Swedish adults wore accelerometers during four consecutive weeks. The number of days needed to come within 5-50% of an individual's usual physical activity 95% of the time was calculated. To get an idea of the uncertainty of the estimates all statistical estimates were bootstrapped 2000 times. The mean number of days of measurement needed for the observation to, with 95% confidence, be within 20% of the habitual physical activity of an individual is highest for vigorous physical activity, for which 182 days are needed. For sedentary behaviour the equivalent number of days is 2.4. To capture 80% of the sample to within ±20% of their habitual level of physical activity, 3.4 days is needed if sedentary behavior is the outcome of interest, and 34.8 days for MVPA. The present study shows that for analyses requiring accurate data at the individual level a longer measurement collection period than the traditional 7-day protocol should be used. In addition, the amount of MVPA was negatively associated with the number of days required to identify the habitual physical activity level indicating that the least active are also those whose habitual physical activity level is the most difficult to identify. These results could have important implications for researchers whose aim is to analyse data on an individual level. Before recommendations regarding an appropriate monitoring protocol are updated, the present study should be replicated in different populations.

National Category
Public Health, Global Health, Social Medicine and Epidemiology Sport and Fitness Sciences
Research subject
Social Sciences, Sport Science
Identifiers
urn:nbn:se:lnu:diva-70902 (URN)10.1371/journal.pone.0192117 (DOI)000423793400069 ()
Available from: 2018-02-14 Created: 2018-02-14 Last updated: 2018-02-15Bibliographically approved
Carlsson, J., Danielsson, T. & Bergman, P. (2017). A two-peaked increase of serum myosin heavy chain-α after full distance triathlon demonstrates heart muscle cell death. In: : . Paper presented at 83th Annual Meeting of the German Cardiac Society – Cardiac and Circulation Research, Mannheim, Germany, April 19-22, 2017. Springer, 106, Article ID P1159.
Open this publication in new window or tab >>A two-peaked increase of serum myosin heavy chain-α after full distance triathlon demonstrates heart muscle cell death
2017 (English)Conference paper, Oral presentation only (Refereed)
Abstract [en]

Background: There is an ongoing debate about the significance of cardiac troponin T (cTnT) elevation after strenuous exercise: heart muscle cell death versus physiologic mechanism of release through an intact cell membrane. While cTnT is a small molecule (37 kDa), cardiac specific myosin heavy chain-alpha (MHC-α) is much larger (224 kDa) and an increase after exercise could hardly be explained by passage through an intact cardiac cell membrane. PURPOSE: To measure MHC-α, and other biomarkers (C-reactive protein (CRP); cTnT, creatine kinase (CK), myoglobin (MG), creatinine (C), and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) before and after a full distance Ironman in order to answer the question of heart muscle cell death versus physiologic changes. 

Methods: In 52 non-elite athletes (14 female, 38 male; age 41.1 ± 9.7, range 24-70 years; all completed the race) biomarkers were measured by standard laboratory methods 7 days before, directly after, and day 1, 4 and 6 after the race. MHC-α was measured with a commercially available ELISA with no cross reactivity with other myosins. 

Results: The course of MHC-α concentration [µg/L] was 1.33 ± 0.53 (before), 2.57 ± 0.78 (directly after), 1.51 ± 0.53 (day 1), 2.74 ± 0.55 (day 4) and 1.83 ± 0.76 (day 6). Other biomarkers showed a one-peaked increase with maximal values either directly after the race or at day 1: cTnT 76 ± 80 ng/L (12-440; reference <15), NT-proBNP 776 ± 684 ng/L (92-4700; ref. < 300), CK 68 ± 55 µkat/L (5-280; ref. < 1.9), MG 2088 ± 2350 µg/L (130-17000; ref.< 72), and creatinine 100 ± 20 µmol/L (74-161; ref. < 100), CRP 49 ± 23 mg/L (15-119; ref.< 5). There was a significant correlation between MHC-α and NT-proBNP (R=0.48; p<0.001) but neither between MHC-α and cTnT (R=0.13; p=0.36) nor MHC-α and myoglobin (R=0.18; p=0.2). 

Conclusion: An Ironman leads to remarkable disturbances in biomarkers as e.g. cTnT was in the range of myocardial infarction in 100% of women and 97% of men. This is to our best knowledge the first investigation of MHC-α after strenuous exercise and its two-peaked increase most likely represents first release from the cytosolic pool and later from cell necrosis including the contractile apparatus. However, many questions remain, not at least why MHC-α baseline levels are as high as 1.33 ± 0.53 µg/L. 

Place, publisher, year, edition, pages
Springer, 2017
Series
Clinical Research in Cardiology, ISSN 1861-0684, E-ISSN 1861-0692
National Category
Cardiac and Cardiovascular Systems
Research subject
Health and Caring Sciences
Identifiers
urn:nbn:se:lnu:diva-67877 (URN)10.1007/s00392-017-1105-2 (DOI)
Conference
83th Annual Meeting of the German Cardiac Society – Cardiac and Circulation Research, Mannheim, Germany, April 19-22, 2017
Available from: 2017-09-08 Created: 2017-09-08 Last updated: 2017-09-19Bibliographically approved
Håkansson, K., Ledreux, A., Daffner, K., Terjestam, Y., Bergman, P., Carlsson, R., . . . Mohammed, A. K. H. (2017). BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, and Mindfulness: Associations with Working Memory Function. Journal of Alzheimer's Disease, 55(2), 645-657
Open this publication in new window or tab >>BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, and Mindfulness: Associations with Working Memory Function
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2017 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 55, no 2, p. 645-657Article in journal (Refereed) Published
Abstract [en]

Brain-derived neurotrophic factor (BDNF) has a central role in brain plasticity by mediating changes in cortical thickness and synaptic density in response to physical activity and environmental enrichment. Previous studies suggest that physical exercise can augment BDNF levels, both in serum and the brain, but no other study has examined how different types of activities compare with physical exercise in their ability to affect BDNF levels. By using a balanced cross over experimental design, we exposed nineteen healthy older adults to 35-minute sessions of physical exercise, cognitive training, and mindfulness practice, and compared the resulting changes in mature BDNF levels between the three activities. We show that a single bout of physical exercise has significantly larger impact on serum BDNF levels than either cognitive training or mindfulness practice in the same persons. This is the first study on immediate BDNF effects of physical activity in older healthy humans and also the first study to demonstrate an association between serum BDNF responsivity to acute physical exercise and working memory function. We conclude that the BDNF increase we found after physical exercise more probably has a peripheral than a central origin, but that the association between post-intervention BDNF levels and cognitive function could have implications for BDNF responsivity in serum as a potential marker of cognitive health.

National Category
Psychology Neurosciences
Research subject
Social Sciences, Psychology
Identifiers
urn:nbn:se:lnu:diva-59565 (URN)10.3233/JAD-160593 (DOI)000389695700018 ()27716670 (PubMedID)
Projects
SAGE
Funder
The Kamprad Family Foundation
Available from: 2017-01-02 Created: 2017-01-02 Last updated: 2018-01-13Bibliographically approved
Danielsson, T., Carlsson, J., Schreyer, H., Ahnesjö, J., ten Siethoff, L., Ragnarsson, T., . . . Bergman, P. (2017). Blood biomarkers in male and female participants after an Ironman-distance triathlon. PLoS ONE, 12(6), 1-9, Article ID e0179324.
Open this publication in new window or tab >>Blood biomarkers in male and female participants after an Ironman-distance triathlon
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2017 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 6, p. 1-9, article id e0179324Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: While overall physical activity is clearly associated with a better short-term and long-term health, prolonged strenuous physical activity may result in a rise in acute levels of blood-biomarkers used in clinical practice for diagnosis of various conditions or diseases. In this study, we explored the acute effects of a full Ironman-distance triathlon on biomarkers related to heart-, liver-, kidney- and skeletal muscle damage immediately post-race and after one week's rest. We also examined if sex, age, finishing time and body composition influenced the post-race values of the biomarkers.

METHODS: A sample of 30 subjects was recruited (50% women) to the study. The subjects were evaluated for body composition and blood samples were taken at three occasions, before the race (T1), immediately after (T2) and one week after the race (T3). Linear regression models were fitted to analyse the independent contribution of sex and finishing time controlled for weight, body fat percentage and age, on the biomarkers at the termination of the race (T2). Linear mixed models were fitted to examine if the biomarkers differed between the sexes over time (T1-T3).

RESULTS: Being male was a significant predictor of higher post-race (T2) levels of myoglobin, CK, and creatinine levels and body weight was negatively associated with myoglobin. In general, the models were unable to explain the variation of the dependent variables. In the linear mixed models, an interaction between time (T1-T3) and sex was seen for myoglobin and creatinine, in which women had a less pronounced response to the race.

CONCLUSION: Overall women appear to tolerate the effects of prolonged strenuous physical activity better than men as illustrated by their lower values of the biomarkers both post-race as well as during recovery.

National Category
Sport and Fitness Sciences
Research subject
Social Sciences, Sport Science
Identifiers
urn:nbn:se:lnu:diva-65765 (URN)10.1371/journal.pone.0179324 (DOI)28609447 (PubMedID)
Available from: 2017-06-22 Created: 2017-06-22 Last updated: 2017-11-29Bibliographically approved
Danielsson, T., Bergman, P. & Carlsson, J. (2017). Maximal Oxygen Consumption Predicts Skeletal and Heart Muscle Biomarkers Changes after a Full Distance Ironman. In: Svenska Hjärtförbundet (Ed.), 19:e Kardiovaskulära Vårmötet 2017: . Paper presented at 19:e Kardiovaskulära Vårmötet 2017, 26-28 april, Malmö. , Article ID 148-A-A1701.
Open this publication in new window or tab >>Maximal Oxygen Consumption Predicts Skeletal and Heart Muscle Biomarkers Changes after a Full Distance Ironman
2017 (English)In: 19:e Kardiovaskulära Vårmötet 2017 / [ed] Svenska Hjärtförbundet, 2017, article id 148-A-A1701Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Maximal Oxygen Consumption Predicts Skeletal and Heart Muscle Biomarkers Changes after a Full Distance Ironman

 

Strenuous exercise like marathon or triathlon leads to disturbances of several biomarkers, not at least markers of skeletal and heart muscle damage. Different predictors of biomarker changes, e.g. sex, age and training experience have been discussed in the literature with contradictory results. To our best knowledge, maximal oxygen consumption (VO2 max) has not been investigated in this setting.

PURPOSE:  To evaluate predictors of biomarker changes in an Ironman triathlon.

METHODS: In 39 non-elite athletes (10 female, 29 male; age 41.1 ± 9.7, range 24-70 years) who had performed a 20 m shuttle run test to predict VO2 max, biomarkers (cardiac troponin T (cTnT; reference < 14 ng/L), creatine kinase (CK; ref. < 1.9 µkat/L), myoglobin (MG; ref. <72 µg/L), and N-terminal prohormone of brain natriuretic peptide (NT-proBNP; ref. < 300 ng/L) were measured by standard laboratory methods 7 days before, directly after, and day 1, and 6 after the race.

RESULTS: VO2 max was on average 49.9 ± 6.4 O2 ml/kg/minute (range 36.5-63.9). Three biomarkers measured directly after the race were predicted by VO2 max: CK (53 ± 50 µkat/L; R= -0.44; p=0.005), MG (2137 ± 2614 µg/L; R= -0.31; p=0.056) and NT-proBNP (772 ±2614 ng/L; R= -0.35; p=0.027). cTnT (75 ± 89) was not significantly predicted by VO2 max but cTnT leakage was, in contrast to the other biomarkers, higher with higher VO2 max (R= 0.10; p=0.55) and return to normal appeared to be faster with higher VO2 max.

CONCLUSION: Earlier research into predictors of biomarker changes after strenuous exercise has found contradictory results concerning age, sex and training experience. In the present Kalmar IronWoMan study VO2 max was found to be a good predictor of biomarker changes with higher VO2 max values being correlated to lower values for CK, NT-proBNP and MG.           

National Category
Sport and Fitness Sciences
Research subject
Social Sciences, Sport Science
Identifiers
urn:nbn:se:lnu:diva-62793 (URN)
Conference
19:e Kardiovaskulära Vårmötet 2017, 26-28 april, Malmö
Available from: 2017-05-03 Created: 2017-05-03 Last updated: 2017-05-30Bibliographically approved
Danielsson, T., Carlsson, J. & Bergman, P. (2017). Maximal Oxygen Consumption Predicts Skeletal and Heart Muscle Biomarkers Changes after a Full Distance Ironman. Paper presented at Annual Meeting of the American-College-of-Sports-Medicine (ACSM), Denver, CO, May 30-Jun 3, 2017. Medicine & Science in Sports & Exercise, 49(5), 519, Article ID 1905.
Open this publication in new window or tab >>Maximal Oxygen Consumption Predicts Skeletal and Heart Muscle Biomarkers Changes after a Full Distance Ironman
2017 (English)In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 49, no 5, p. 519-, article id 1905Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

Strenuous exercise like marathon or triathlon leads to disturbances of several biomarkers, not at least markers of skeletal and heart muscle damage. Different predictors of biomarker changes, e.g. sex, age and training experience have been discussed in the literature with contradictory results. To our best knowledge, maximal oxygen consumption (VO2 max) has not been investigated in this setting.

PURPOSE:  To evaluate predictors of biomarker changes in an Ironman triathlon.

METHODS: In 39 non-elite athletes (10 female, 29 male; age 41.1 ± 9.7, range 24-70 years) who had performed a 20 m shuttle run test to predict VO2 max, biomarkers (cardiac troponin T (cTnT; reference < 14 ng/L), creatine kinase (CK; ref. < 1.9 µkat/L), myoglobin (MG; ref. <72 µg/L), and N-terminal prohormone of brain natriuretic peptide (NT-proBNP; ref. < 300 ng/L) were measured by standard laboratory methods 7 days before, directly after, and day 1, and 6 after the race.

RESULTS: VO2 max was on average 49.9 ± 6.4 O2 ml/kg/minute (range 36.5-63.9). Three biomarkers measured directly after the race were predicted by VO2 max: CK (53 ± 50 µkat/L; R= -0.44; p=0.005), MG (2137 ± 2614 µg/L; R= -0.31; p=0.056) and NT-proBNP (772 ±2614 ng/L; R= -0.35; p=0.027). cTnT (75 ± 89) was not significantly predicted by VO2 max but cTnT leakage was, in contrast to the other biomarkers, higher with higher VO2 max (R= 0.10; p=0.55) and return to normal appeared to be faster with higher VO2 max.

CONCLUSION: Earlier research into predictors of biomarker changes after strenuous exercise has found contradictory results concerning age, sex and training experience. In the present Kalmar IronWoMan study VO2 max was found to be a good predictor of biomarker changes with higher VO2 max values being correlated to lower values for CK, NT-proBNP and MG.           

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2017
National Category
Sport and Fitness Sciences
Research subject
Natural Science, Medicine
Identifiers
urn:nbn:se:lnu:diva-64890 (URN)10.1249/01.mss.0000518333.84594.1c (DOI)000415214600695 ()
Conference
Annual Meeting of the American-College-of-Sports-Medicine (ACSM), Denver, CO, May 30-Jun 3, 2017
Projects
IRONMAN
Available from: 2017-06-07 Created: 2017-06-07 Last updated: 2018-01-10Bibliographically approved
Demmelmeier, I., Åsenlöf, P., Bergman, P., Nordgren, B. & Opava, C. H. (2017). Pain rather than self-reported sedentary time explains variation in perceived health and activity limitation in persons with rheumatoid arthritis: a cross sectional study in Sweden. Rheumatology International, 37(6), 923-930
Open this publication in new window or tab >>Pain rather than self-reported sedentary time explains variation in perceived health and activity limitation in persons with rheumatoid arthritis: a cross sectional study in Sweden
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2017 (Swedish)In: Rheumatology International, ISSN 0172-8172, E-ISSN 1437-160X, Vol. 37, no 6, p. 923-930Article in journal (Refereed) Published
Abstract [en]

To investigate (1) the amount of self-reported time spent sedentary among a large cohort of persons with rheumatoid arthritis (RA), and (2) the contribution of sedentary time to explain perceived health and activity limitation in RA beyond that of previously known correlates. This cross-sectional study used data from a postal questionnaire and the Swedish Rheumatology Quality registers (SRQ). The International Physical Activity Questionnaire was used to assess sedentary time (sitting) and moderate, vigorous and walking activity (MVPA). Sociodemographics, pain, fatigue, fear-avoidance beliefs, anxiety/depression, disease duration, MVPA and sedentary time were included in multiple regression models with perceived health (Visual Analogue Scale 0-100) and activity limitation (Stanford Health Assessment Questionnaire) as dependent variables.

RESULTS:

In all 3152 (59%) of 5391 persons identified as eligible from the SRQ, responded to the questionnaire. 2819 individuals with complete data on all study variables were analysed. Mean time (SD) spent sedentary was 257 (213) minutes per day. Sedentary time did not contribute significantly to explain perceived health and only minimally to explain activity limitation. Instead, variation was mainly explained by pain; for perceived health (Beta = 0.780, p < 0.001) and for activity limitation (Beta = 0.445, p < 0.001).The results indicate a non-significant role of sedentary time and a need for increased focus on pain in the management of RA. Future studies should use prospective designs and objective assessment methods to further investigate the associations between sedentary time and health outcomes in persons with R

Place, publisher, year, edition, pages
Springer, 2017
National Category
Rheumatology and Autoimmunity Sport and Fitness Sciences
Research subject
Social Sciences, Sport Science
Identifiers
urn:nbn:se:lnu:diva-61398 (URN)10.1007/s00296-016-3641-x (DOI)000401632400009 ()28124094 (PubMedID)
Available from: 2017-03-15 Created: 2017-03-15 Last updated: 2017-07-19Bibliographically approved
Carlsson, J., Danielsson, T. & Bergman, P. (2017). Two-peaked increase of serum myosin heavy chain-α after Ironman demonstrates heart muscle cell death. Medicine & Science in Sports & Exercise, 47(5 Supplement 1), 186, Article ID 734.
Open this publication in new window or tab >>Two-peaked increase of serum myosin heavy chain-α after Ironman demonstrates heart muscle cell death
2017 (English)In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 47, no 5 Supplement 1, p. 186-, article id 734Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2017
National Category
Cardiac and Cardiovascular Systems
Research subject
Health and Caring Sciences
Identifiers
urn:nbn:se:lnu:diva-69690 (URN)000414071200538 ()
Available from: 2018-01-10 Created: 2018-01-10 Last updated: 2018-01-10Bibliographically approved
Ahnesjö, J. & Bergman, P. (2016). Effects on white blood cells in senior citizens during post exercise recovery in three different environments (indoors, simulated outdoors and outdoors). In: : . Paper presented at European college of sport science "crossing borders through sport science" 6-9 July, Vienna, Austria.
Open this publication in new window or tab >>Effects on white blood cells in senior citizens during post exercise recovery in three different environments (indoors, simulated outdoors and outdoors)
2016 (English)Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

Introduction

Natural environments are known to promote health and may also provide extraordinary conditions for post exercise recovery (Kuo 2015). In the project Health Effects of Recreation Outdoors (HERO) we explore the hypothesis that post exercise recovery in natural environments may be reflected in white blood cell counts (WBC). In our study 50 seniors (age >65 years) performed moderate physical activity (20 min) followed by passive recovery (2h) in three different environments (indoors, simulated outdoors and “true” outdoors).

Method

The experimental setup was a randomized cross-over design, thus all test persons did all treatments in a randomized order. We sampled white blood cells (WBC-diff), which were used to detect and quantify inflammatory response.

Results

Our early findings provide some support for the hypothesis that environment may impose differences in recovery effectiveness. White blood cell count (WBC-diff) appears to differ between the treatments and there is a significant interaction between sampling time and recovery environment in the monocytes, suggesting that the monocyte numbers differ, not only between sampling times but also between environments. In addition, WBC also show that some of the test persons develop leukocytosis during exercise and that white blood cell levels decrease rapidly immediately post exercise to levels significantly lower than base line values.

Discussion

Our results suggest that moderate physical activity in senior citizens may result in acute leukocytosis (see e.g. Sand et. al. 2013) and that recovery effectiveness (e.g in monocyte response) may be dependent upon environmental factors. The clinical importance of our results are not fully understood but there has been suggested an “open window” immediately post exercise in which infection risk may be elevated (Pedersen & Toft 2000) and it is possible that recovery out of doors may reduce this risk.

References

Sand, K., L, Flatebo, K., Andersen, M., B., Maghazachi, A., A. (2013) World J Exp Med 20; 3(1): 11-20

Pedersen, B., K. & Toft, A., D. (2000) Br J Sports Med 34:246–251

Kuo, M. (2015) Frontiers in Psychology 6:1-8

National Category
Sport and Fitness Sciences
Research subject
Social Sciences, Sport Science
Identifiers
urn:nbn:se:lnu:diva-55643 (URN)
Conference
European college of sport science "crossing borders through sport science" 6-9 July, Vienna, Austria
Projects
HERO
Note

Project funded by:

The Kamprad Family Foundation for Entrepreneurship, Research and Charity

ref no 20132082

Available from: 2016-08-19 Created: 2016-08-19 Last updated: 2017-01-16Bibliographically approved
Carlsson, J., Ragnarsson, T., Danielsson, T., Johansson, T., Schreyer, H., Breyne, A. & Bergman, P. (2016). Hjärtmarkörer ökar efter intensiv motion - oklar klinisk betydelse: Data från förstudie av Kalmar IronWoman-studien visar på troponin T-värden som vid hjärtinfarkt. Läkartidningen, 113(31-33), Article ID D3CR.
Open this publication in new window or tab >>Hjärtmarkörer ökar efter intensiv motion - oklar klinisk betydelse: Data från förstudie av Kalmar IronWoman-studien visar på troponin T-värden som vid hjärtinfarkt
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2016 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 113, no 31-33, article id D3CRArticle in journal (Refereed) Published
Abstract [en]

Biochemical changes after strenuous exercise - data from the Kalmar Ironman

Strenuous and prolonged exercise like marathon, ultra running and triathlon can lead to changes in biomarkers of cardiac, muscle and kidney functional damage. We present the data of 30 (15 men, 15 women) participants of the Kalmar Ironman 2015. Pre-race electrocardiograms and echocardiograms showed a high frequency of abnormalities. Post race elevations of troponin T, creatine kinase, myoglobin, N-terminal prohormone of brain natriuretic peptide, and creatinine returned to normal in almost all cases within 5-8 days. In all but one participant the troponin T pattern was compatible with the diagnosis of myocardial infarction. It is an up-to-date unanswered question whether the increase of troponin represents myocardial damage or just is a benign consequence of an intermittent change of the permeability of myocardial cell membranes.

Abstract [sv]

Intensiv uthållighetsidrott som maratonlöpning och triatlon påverkar alla organsystem, och akuta förändringar har visats inte minst för hjärt- och njurfunktion.   

Vi rapporterar data från 30 deltagare i Kalmar Ironman (15 män, 15 kvinnor) som undersökts med EKG, ekokardiografi och blodprov.

Akuta stegringar av hjärt-, muskel- och njurvärden var mycket vanliga. Samtliga deltagare förutom en uppvisade direkt efter tävlingen troponin T-värden som skulle vara förenliga med diagnosen hjärtinfarkt. 

Det är oklart om troponinläckaget står för en hjärtmuskelskada eller om det är en godartad konsekvens av en tillfällig ändring av permeabiliteten av hjärtmuskelcellerna.

Place, publisher, year, edition, pages
Läkartidningen Förlag, 2016
National Category
Cardiac and Cardiovascular Systems
Research subject
Natural Science, Medicine
Identifiers
urn:nbn:se:lnu:diva-55132 (URN)
Available from: 2016-08-08 Created: 2016-08-08 Last updated: 2017-11-28Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-4934-8684

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