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Nordqvist, O., Lönnbom Svensson, U., Brundin, L., Wanby, P. & Carlsson, M. (2019). Adherence to risk management guidelines for drugs which cause vitamin D deficiency – big data from the Swedish health system. Drug, Healthcare and Patient Safety, 11, 19-28
Open this publication in new window or tab >>Adherence to risk management guidelines for drugs which cause vitamin D deficiency – big data from the Swedish health system
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2019 (English)In: Drug, Healthcare and Patient Safety, ISSN 1179-1365, E-ISSN 1179-1365, Vol. 11, p. 19-28Article in journal (Refereed) Published
Abstract [en]

Purpose: Several medications are known to cause vitamin D deficiency. The aim of this study is to describe vitamin D testing and supplementation in patients using these “risk medications”, thereby assessing adherence to medical guidelines.Patients and methods: A database with electronic health records for the population in a Swedish County (≈240,000 inhabitants) was screened for patients prescribed the pre-defined “risk medications” during a 2-year period (2014–2015). In total, 12,194 patients were prescribed “risk medications” pertaining to one of the three included pharmaceutical groups. Vitamin D testing and concomitant vitamin D supplementation, including differences between the included pharmaceutical groups, was explored by matching personal identification numbers.Results: Corticosteroids were prescribed to 10,003 of the patients, antiepileptic drugs to 1,101, and drugs mainly reducing vitamin D uptake to 864. Two hundred twenty-six patients were prescribed >1 “risk medication”. Seven hundred eighty-seven patients (6.5%) had been tested during the 2-year period. There were no differences regarding testing frequency between groups. Concomitant supplements were prescribed to 3,911 patients (32.1%). It was more common to be prescribed supplements when treated with corticosteroids. Vitamin D supplementation was more common among tested patients in all three groups. Women were tested and supplemented to a higher extent. The mean vitamin D level was 69 nmol/L. Vitamin D deficiency was found in 24.1% of tested patients, while 41.3% had optimal levels. It was less common to be deficient and more common to have optimal levels among patients prescribed corticosteroids.Conclusion: Adherence to medical guidelines comprising testing and supplementation of patients prescribed drugs causing vitamin D deficiency needs improvement in Sweden.

Place, publisher, year, edition, pages
Dove Medical Press Ltd, 2019
National Category
Pharmaceutical Sciences
Research subject
Biomedical Sciences, Pharmacology
Identifiers
urn:nbn:se:lnu:diva-81355 (URN)10.2147/DHPS.S188187 (DOI)000462173500001 ()
Available from: 2019-03-28 Created: 2019-03-28 Last updated: 2019-04-11Bibliographically approved
Mathold, K., Wanby, P., Brudin, L., Von, S. P. & Carlsson, M. (2018). Alterations in bone turnover markers in patients with noncardio-embolic ischemic stroke. PLoS ONE, 13(11), Article ID e0207348.
Open this publication in new window or tab >>Alterations in bone turnover markers in patients with noncardio-embolic ischemic stroke
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2018 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 11, article id e0207348Article in journal (Refereed) Published
Abstract [en]

Background The major cause of ischemic stroke is unstable or thrombogenic atherosclerotic plaques. Vascular calcification, a process that appears crucial for plaque stability, shares common features with bone formation. Many bone turnover proteins exhibit metabolic properties, but the evidence is conflicting regarding their possible involvement in vascular disease. Antibodies against sclerostin and dickkopf-1 are currently being evaluated as potential therapy for treating bone disorders. It is important to carefully assess the cardiovascular and metabolic effects of these proteins. The aim of the present study was to explore serum levels of bone turnover markers in patients with acute noncardio-embolic ischemic stroke in comparison with healthy controls. Methods In a cross-sectional study, we compared 48 patients aged. 75 years with noncardio-embolic ischemic stroke and 46 healthy controls. Serum levels of dickkopf-1, sclerostin, osteoprotegerin, osteopontin and osteocalcin were determined by Luminex technique. Results We found clearly increased serum levels of osteoprotegerin, sclerostin, dickkopf-1 and osteopontin in patients with stroke compared with healthy controls. No difference was seen in serum levels of osteocalcin between the two groups. Conclusion Our findings strengthen the hypothesis of bone turnover markers being involved in vascular disease. Whether these proteins can be used as candidate markers for increased stroke risk or prognostic biomarkers remains to be further elucidated.

Place, publisher, year, edition, pages
San Francisco: Public Library of Science (PLoS), 2018
National Category
Cardiac and Cardiovascular Systems
Research subject
Natural Science, Medicine
Identifiers
urn:nbn:se:lnu:diva-79611 (URN)10.1371/journal.pone.0207348 (DOI)000451763800027 ()30496210 (PubMedID)2-s2.0-85057492323 (Scopus ID)
Available from: 2019-01-18 Created: 2019-01-18 Last updated: 2019-08-29Bibliographically approved
Carlsson, M., Brudin, L. & Wanby, P. (2018). Directly measured free 25-hydroxy vitamin D levels show no evidence of vitamin D deficiency in young Swedish women with anorexia nervosa. Eating and Weight Disorders, 23(2), 247-254
Open this publication in new window or tab >>Directly measured free 25-hydroxy vitamin D levels show no evidence of vitamin D deficiency in young Swedish women with anorexia nervosa
2018 (English)In: Eating and Weight Disorders, ISSN 1124-4909, E-ISSN 1590-1262, Vol. 23, no 2, p. 247-254Article in journal (Refereed) Published
Abstract [en]

Purpose Anorexia nervosa (AN) is an eating disorder characterized by low fat mass complicated by osteoporosis. The role of circulating vitamin D in the development of bone loss in AN is unclear. Fat mass is known to be inversely associated with vitamin D levels measured as serum levels of total, protein-bound 25-hydroxyvitamin D, but the importance of directly measured, free levels of 25(OH)D has not been determined in AN. The aim of this study was to investigate vitamin D status, as assessed by serum concentrations of total and free serum 25(OH)D in patients with AN and healthy controls. Methods In female AN patients (n = 20), and healthy female controls (n = 78), total 25(OH)D was measured by LC-MS/MS, and free 25(OH)D with ELISA. In patients with AN bone mineral density (BMD) was determined with DEXA. Results There were no differences between patients and controls in total or free S-25(OH)D levels (80 +/- 31 vs 72 +/- 18 nmol/L, and 6.5 +/- 2.5 vs 5.6 +/- 1.8 pg/ml, respectively), and no association to BMD was found. In the entire group of patients and controls, both vitamin D parameters correlated with BMI, leptin, and PTH. Conclusions The current study did not demonstrate a vitamin D deficiency in patients with AN and our data does not support vitamin D deficiency as a contributing factor to bone loss in AN. Instead, we observed a trend toward higher vitamin D levels in AN subjects compared to controls. Measurement of free vitamin D levels did not contribute to additional information.

Place, publisher, year, edition, pages
Springer, 2018
Keywords
Osteoporosis, Vitamin D, Adipose tissue, Anorexia nervosa, Leptin, Parathyroid hormone
National Category
Other Clinical Medicine
Research subject
Natural Science, Medicine
Identifiers
urn:nbn:se:lnu:diva-72685 (URN)10.1007/s40519-017-0392-y (DOI)000428082700013 ()28455680 (PubMedID)2-s2.0-85034639139 (Scopus ID)
Available from: 2018-04-13 Created: 2018-04-13 Last updated: 2019-08-29Bibliographically approved
Ericson, L., Hovstadius, B., Carlsson, M., Petersson, G. & Wanby, P. (2017). A cost analysis of systematic vitamin D supplementation in the elderly versus supplementation based on assessed requirements. Journal of Aging Research and Healthcare, 2(2), 13-22
Open this publication in new window or tab >>A cost analysis of systematic vitamin D supplementation in the elderly versus supplementation based on assessed requirements
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2017 (English)In: Journal of Aging Research and Healthcare, ISSN 2474-7785, Vol. 2, no 2, p. 13-22Article in journal (Refereed) Published
Abstract [en]

Hypovitaminosis D is common among older people and treatment with vitamin D is associated with reduced risk of falls and fractures. This paper provides a cost analysis of assessing the vitamin D status of and providing the pharmaceuticals for elderly citizens in Kalmar County, Sweden (population approximately 230,000). Four hypothetical interventions were analyzed: (a) systematic vitamin D/calcium supplementation to all elderly (≥75 years), (b) assessment of vitamin D status in elderly and supplementation to those with insufficient levels, (c) systematic vitamin D/calcium supplementation to all nursing-home residents, and (d) assessment of vitamin D status in nursing-home residents and supplementation to those with insufficient levels. The calculations were based on an estimated reduction in overall costs due to the assessed number of hip fractures after vitamin D/calcium supplementation. The annual net economic benefit of vitamin D/calcium supplementation was estimated at (a) €304,000, (b) €860,000, (c) €755,000, and (d) €740,000. The provision of systematic vitamin D supplementation to nursing-home residents would provide a substantial net economic benefit to society and assessment of the vitamin D status before starting supplementation does not seem to be necessary. Although assessment of all elderly citizens would be more comprehensive, the true proportion with insufficient vitamin D levels in the general population is uncertain and to reaching consensus on the most advantageous daily vitamin D intake, vitamin D blood levels are necessary. Also, systematic supplementation to all elderly would result in other outcomes that could be worth the cost, but that remains to be evaluated.

Place, publisher, year, edition, pages
Valley Cottage, NY: Open Access Pub, 2017
Keywords
Vitamin D, Supplementation, Screening, Cost, Frail elderly
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Health and Caring Sciences; Health and Caring Sciences
Identifiers
urn:nbn:se:lnu:diva-67953 (URN)10.14302/issn.2474-7785.jarh-17-1724 (DOI)
Projects
Betydelsen av bra D-vitaminstatus för äldres hälsa
Funder
The Kamprad Family Foundation, 20130084
Available from: 2017-09-14 Created: 2017-09-14 Last updated: 2019-09-05Bibliographically approved
Carlsson, M., Nilsson, I., Brudin, L., Von, S.-P. & Wanby, P. (2017). Erythrocyte fatty acid composition does not influence levels of free, bioavailable, and total 25-hydroxy vitamin D. Scandinavian Journal of Clinical and Laboratory Investigation, 77(1), 45-52
Open this publication in new window or tab >>Erythrocyte fatty acid composition does not influence levels of free, bioavailable, and total 25-hydroxy vitamin D
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2017 (English)In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 77, no 1, p. 45-52Article in journal (Refereed) Published
Abstract [en]

In vitro, mono- and polyunsaturated fatty acids (FAs) may decrease the binding affinity of vitamin D metabolites for vitamin D-binding protein, which in turn may influence their bioavailability. FAs incorporated as phospholipids in erythrocyte (ery-) cell membranes reflect dietary intake. The purpose of this study was to investigate ery-FA composition in relation to markers for vitamin D. In healthy females (age 22.6 +/- 2.0 years) total 25(OH)D was measured by LC-MS/MS (n=78), free 25(OH)D with ELISA (n=64 of 78), and bioavailable 25(OH)D was calculated. Analysis of ery-FA composition was by gas chromatography (n=56 of 78). A strong correlation between total 25(OH)D and free 25(OH)D was seen (r=.66, p<.001), and between total-25(OH)D and bioavailable 25(OH)D (r=.68, p<.001). No correlations between 25(OH)D fractions and specific fatty acids were found, and in particular, no associations with mono- and poly-unsaturated FA compositions. All 25(OH)D fractions were correlated with leptin (total 25(OH)D (r=-.33, p<.003); bioavailable 25(OH)D (r=-.47, p<.001); free 25(OH)D (r=-.44, p<.001). Associations were found between PTH and total 25(OH)D (r=-.35, p=.002) and weaker between bioavailable 25(OH)D (r=-.35, p=.040) and free 25(OH)D (r=-.28, p=.079). All fractions of 25(OH)D appear to correlate in a similar way to PTH, BMI and body fat (leptin). No association was found between ery-FA composition and free/bioavailable 25(OH)D. It is unlikely that FAs are a strong uncoupling factor of DBP-bound 25(OH)D.

Place, publisher, year, edition, pages
Taylor & Francis, 2017
Keywords
Erythrocyte membrane, fatty acids, leptin, lipids, parathyroid hormone, Vitamin D
National Category
Clinical Laboratory Medicine
Research subject
Natural Science, Biomedical Sciences
Identifiers
urn:nbn:se:lnu:diva-60253 (URN)10.1080/00365513.2016.1258724 (DOI)000390847200009 ()2-s2.0-85000774413 (Scopus ID)
Available from: 2017-01-26 Created: 2017-01-26 Last updated: 2019-09-09Bibliographically approved
Wanby, P., Berglund, J., Brudin, L., Hedberg, D. & Carlsson, M. (2016). Increased ferritin levels in patients with anorexia nervosa: impact of weight gain.. Eating and Weight Disorders, 21(3), 411-417
Open this publication in new window or tab >>Increased ferritin levels in patients with anorexia nervosa: impact of weight gain.
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2016 (English)In: Eating and Weight Disorders, ISSN 1124-4909, E-ISSN 1590-1262, Vol. 21, no 3, p. 411-417Article in journal (Refereed) Published
Abstract [en]

PURPOSE: A few recent studies have found elevated ferritin levels in patients with anorexia nervosa (AN), indicating ferritin as a potential biomarker of disease severity. The purpose of this study was to study how body mass index (BMI) and changes in BMI affect plasma ferritin concentrations in Swedish patients with eating disorders.

MATERIALS AND METHODS: In a retrospective computer search from 2009 to 2014, 662 patients with an eating disorder were identified from more than 200,000 individuals with electronic medical records. Three hundred and eighty-nine patients (374 females and 15 males) were found to have at least one p-ferritin value with a corresponding BMI value. Patients with AN were compared to a combined group consisting of patients with bulimia nervosa (BN) and patients with an eating disorder not otherwise specified (EDNOS).

RESULTS: Patients with AN had lower BMI compared to the combined group of patients with other eating disorders (BMI = 16.5 ± 1.5, n = 77 vs. 21.0 ± 4.7, n = 312, p < 0.001). Patients with AN also had higher plasma ferritin levels (median 42 μg/L (range 3.3-310) vs. 31 μg/L (range 2.8-280); p < 0.001). As BMI increased in patients with AN, ferritin levels decreased (from a median of 40 μg/L (7-400) to 26 (4-170), n = 47; p < 0.001).

DISCUSSION: Measuring ferritin in patients with AN could be valuable in monitoring improvements of nutritional status, but the full clinical value of following ferritin in individual patients has yet to be determined. The study also shows how research can benefit from electronically captured clinical data using electronic health records.

Place, publisher, year, edition, pages
Springer, 2016
Keywords
Anorexia nervosa, Big data, Biomarker, Electronic health records, Ferritin, Starvation
National Category
Psychiatry Nutrition and Dietetics
Research subject
Natural Science, Medicine
Identifiers
urn:nbn:se:lnu:diva-81172 (URN)10.1007/s40519-015-0246-4 (DOI)000382854900007 ()26830429 (PubMedID)
Available from: 2019-03-19 Created: 2019-03-19 Last updated: 2019-04-16Bibliographically approved
Carlsson, M., Wanby, P., Brudin, L., Lexne, E., Mathold, K., Nobin, R., . . . Petersson, G. (2016). Older Swedish Adults with High Self-Perceived Health Show Optimal 25-Hydroxyvitamin D Levels Whereas Vitamin D Status Is Low in Patients with High Disease Burden. Nutrients, 8(11), Article ID 717.
Open this publication in new window or tab >>Older Swedish Adults with High Self-Perceived Health Show Optimal 25-Hydroxyvitamin D Levels Whereas Vitamin D Status Is Low in Patients with High Disease Burden
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2016 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 8, no 11, article id 717Article in journal (Refereed) Published
Abstract [en]

Controversy pervades the definition of adequate and optimal vitamin D status. The Institutes of Medicine have recommended serum 25(OH) D levels above 50 nmol/L based upon evidence related to bone health, but some experts, including the Endocrine Society and International Osteoporosis Foundation, suggest a minimum serum 25(OH) D level of 75 nmol/L to reduce the risk of falls and fractures in older adults. In a cross-sectional study, we compared vitamin D status in people >= 75 years selected from four groups with a frailty phenotype, combined with a control group free from serious illness, and who considered themselves completely healthy. Only 13% of the 169 controls were vitamin D deficient (S-25(OH) D) < 50 nmol/L), in contrast with 49% of orthopedic patients with hip fractures (n = 133), 31% of stroke patients (n = 122), 39% of patients visiting the hospital's emergency department >= 4 times a year (n = 81), and 75% of homebound adult residents in long-term care nursing homes (n = 51). The mean vitamin D concentration of the healthy control group (74 nmol/L) was similar to a suggested optimal level based on physiological data and mortality studies, and much higher than that of many officially recommended cut-off levels for vitamin D deficiency (< 50 nmol/L). The present study provides a basis for planning and implementing public guidelines for the screening of vitamin D deficiency and vitamin D treatment for frail elderly patients.

Keywords
vitamin D, 25-hydroxyvitamin D, Sweden, emergency care, frail older adult
National Category
Nutrition and Dietetics
Research subject
Natural Science, Medicine
Identifiers
urn:nbn:se:lnu:diva-59470 (URN)10.3390/nu8110717 (DOI)000388666400051 ()2-s2.0-84995616155 (Scopus ID)
Available from: 2016-12-23 Created: 2016-12-23 Last updated: 2019-03-20Bibliographically approved
Wanby, P., Nobin, R., Von, S.-P., Brudin, L. & Carlsson, M. (2016). Serum levels of the bone turnover markers dickkopf-1, sclerostin, osteoprotegerin, osteopontin, osteocalcin and 25-hydroxyvitamin D in Swedish geriatric patients aged 75 years or older with a fresh hip fracture and in healthy controls.. Journal of Endocrinological Investigation, 39(8), 855-863
Open this publication in new window or tab >>Serum levels of the bone turnover markers dickkopf-1, sclerostin, osteoprotegerin, osteopontin, osteocalcin and 25-hydroxyvitamin D in Swedish geriatric patients aged 75 years or older with a fresh hip fracture and in healthy controls.
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2016 (English)In: Journal of Endocrinological Investigation, ISSN 0391-4097, E-ISSN 1720-8386, Vol. 39, no 8, p. 855-863Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Bone turnover markers have a potential clinical use in describing bone remodeling and in predicting fractures.

AIMS: In an elderly population ≥75 years with a fresh hip fracture, and in healthy controls, investigate bone turnover markers and their relation to each other, to vitamin D status and to bone mineral density (BMD).

METHODS: In a cross-sectional study serum levels of dickkopf-1 (DKK-1), sclerostin (SOST), osteoprotegerin (OPG), osteopontin (OPN), osteocalcin, 25-hydroxyvitamin D (25(OH)D) were analyzed in 89 Swedish patients with a fresh hip fracture and in 82 healthy volunteers. Serum levels of bone markers were determined by Luminex technique.

RESULTS: S-25-hydroxyvitamin D (S-25(OH)D) was decreased in patients compared to controls (48 ± 21 vs. 76 ± 25 nmol/L, p < 0.001). SOST, but none of the other bone turnover markers correlated with BMD (r = 0.50, p < 0.001). Compared with controls, higher levels of OPG (488 ± 1.4 vs. 191 ± 1.4 ng/L, p < 0.001), OPN (69 ± 1.7 vs. 19 ± 1.4 µg/L, p < 0.001), DKK-1 (273 ± 1.7 vs. 168 ± 1.7 ng/L, p < 0.001), and lower levels of osteocalcin (5.8 ± 3.5 vs. 9.5 ± 3.6 µg/L, p < 0.001), were found in the fracture group. Levels of OPG, DKK-1 and SOST in both groups were positively associated. S-25(OH)D concentration was not found to be strongly associated with any of the bone markers.

CONCLUSIONS: In contrast to findings in other studies, we found no strong correlation between 25(OH)D and the investigated bone markers. Both in patients with a fresh hip fracture and in healthy elderly, DKK-1, SOST and OPG appear to be associated. This suggests a relevance in these relationships meriting further investigation.

Place, publisher, year, edition, pages
Springer, 2016
Keywords
Bone mineral density, DXA, Magpix, Osteoporosis, PTH, Vitamin D deficiency
National Category
Orthopaedics Geriatrics
Research subject
Natural Science, Medicine
Identifiers
urn:nbn:se:lnu:diva-81173 (URN)10.1007/s40618-015-0421-5 (DOI)000382133700003 ()26850415 (PubMedID)
Available from: 2019-03-19 Created: 2019-03-19 Last updated: 2019-04-16Bibliographically approved
Bengtsson, D., Brudin, L., Wanby, P. & Carlsson, M. (2012). Previously unknown thyroid dysfunction in patients with acute ischemic stroke.. Acta Neurologica Scandinavica, 126(2), 98-102
Open this publication in new window or tab >>Previously unknown thyroid dysfunction in patients with acute ischemic stroke.
2012 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 126, no 2, p. 98-102Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Opinions differ regarding the clinical significance of subclinical thyroid disorders. The aim of the present study was to evaluate the prevalence and influence of previously unknown overt or subclinical thyroid dysfunction in patients with acute ischemic stroke and to look for differences between cardio-embolic and non-embolic ischemic stroke.

MATERIAL AND METHODS: A total of 153 Swedish patients diagnosed with first-time acute ischemic stroke were included in the study and categorized for suspected cardio-embolic (n = 30) or non-embolic (n = 123) ischemic stroke depending on the presence of atrial fibrillation (AF). Blood samples were taken 48 h or earlier after onset of stroke symptoms.

RESULTS: Previously, unknown overt or subclinical thyroid dysfunction was found in 12%. Previously, unknown overt or subclinical hyperthyroidism was more common in the AF group (13%) compared to the non-AF group (3%), P = 0.048. Patients with AF had slightly higher concentrations of free T4 (15 vs 14 pm; P < 0.001), but there was no significant difference in concentrations of S-TSH or prevalence of thyroperoxidase (TPO) antibodies between the groups.

CONCLUSIONS: In patients with first-time acute ischemic stroke, unknown thyroid dysfunction is common, and unknown overt or subclinical hyperthyroidism is associated with cardio-embolic stroke.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2012
National Category
Neurology
Research subject
Natural Science, Medicine
Identifiers
urn:nbn:se:lnu:diva-81212 (URN)10.1111/j.1600-0404.2011.01604.x (DOI)000305935800004 ()22034899 (PubMedID)
Available from: 2019-03-21 Created: 2019-03-21 Last updated: 2019-04-16Bibliographically approved
Carlsson, M., Lindström, T., Nyström, F., Nilsson, I., Brudin, L. & Wanby, P. (2011). Evidence of Daytime Variation of Asymmetric Dimethylarginine: An Intervention Study with Rosiglitazon in Type 2 Diabetes. The Open Endocrinology Journal (5), 14-18
Open this publication in new window or tab >>Evidence of Daytime Variation of Asymmetric Dimethylarginine: An Intervention Study with Rosiglitazon in Type 2 Diabetes
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2011 (English)In: The Open Endocrinology Journal, no 5, p. 14-18Article in journal (Refereed) Published
Abstract [en]

Background: Asymmetric dimethylarginine (ADMA) has in some, but not all studies been associated with insulin resistance (IR). We wanted to challenge the hypothesis that plasma ADMA levels are associated with IR in an intervention study using an insulin sensitizing drug. Another aim of the study was to study daytime ADMA variation and if food intake influence ADMA concentration.

Methods: Nine patients with diet treated type 2 diabetes were investigated with daytime profiles of ADMA (8 am-5 pm) before and during treatment with rosiglitazone for 8 weeks. A control group matched for age and sex underwent a similar investigation at baseline.

Results: After treatment with rosiglitazone, ADMA (0.63- 0.64 mmol/L; p=0.26) and homocysteine (10.3 -10.6 mol/L; p=0.61) concentrations did not change. Postprandial (10 am – 5 pm) ADMA concentrations were 10% higher than fasting morning levels (p=0.006) and this difference was similar for controls and diabetes patients both pre and post treatment with rosiglitazone.

Conclusions: Treatment with rosiglitazone aiming to improve insulin sensitivity did not affect ADMA concentration in type 2 diabetes patients. The ADMA daytime variation and the relation to food intake appear to be a novel finding and should be considered in future studies.

Place, publisher, year, edition, pages
Bentham Open, 2011
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:lnu:diva-81211 (URN)
Available from: 2019-03-21 Created: 2019-03-21 Last updated: 2019-04-16Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-3106-0754

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