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Johansson Östbring, M., Eriksson, T., Petersson, G. & Hellström, L. (2021). Effects of a pharmaceutical care intervention on clinical outcomes and patient adherence in coronary heart disease - the MIMeRiC randomized controlled trial. BMC Cardiovascular Disorders, 21(1), Article ID 367.
Open this publication in new window or tab >>Effects of a pharmaceutical care intervention on clinical outcomes and patient adherence in coronary heart disease - the MIMeRiC randomized controlled trial
2021 (English)In: BMC Cardiovascular Disorders, ISSN 1471-2261, E-ISSN 1471-2261, Vol. 21, no 1, article id 367Article in journal (Refereed) Published
Abstract [en]

Background: In the treatment of coronary heart disease, secondary prevention goals are still often unmet and pooradherence to prescribed drugs has been suggested as one of the reasons. We aimed to investigate whether pharmaceutical care by a pharmacist at the cardiology clinic trained in motivational interviewing improves clinical outcomesand patient adherence.

Methods: This was a prospective, randomized, controlled, outcomes-blinded trial designed to compare pharmaceutical care follow-up with standard care. After standard follow-up at the cardiology clinic, patients in the interventiongroup were seen by a clinical pharmacist two to fve times as required over seven months. Pharmacists were trainedto use motivational interviewing in the consultations and they tailored their support to each patient’s clinical needsand beliefs about medicines. The primary study end-point was the proportion of patients who reached the treatmentgoal for low-density lipoprotein cholesterol by 12 months after discharge. The key secondary outcome was patientadherence to lipid-lowering therapy at 15 months after discharge, and other secondary outcomes were the efectson patient adherence to other preventive drugs, systolic blood pressure, disease-specifc quality of life, and healthcareuse.

Results: 316 patients were included. The proportion of patients who reached the target for low-density lipoproteincholesterol were 37.0% in the intervention group and 44.2% in the control group (P=.263). More intervention thancontrol patients were adherent to cholesterol-lowering drugs (88 vs 77%; P=.033) and aspirin (97 vs 91%; P=.036)but not to beta-blocking agents or renin–angiotensin–aldosterone system inhibitors.

Conclusions: Our intervention had no positive efects on risk factors for CHD, but it increased patient adherence.Further investigation of the intervention process is needed to explore the diference in results between patient adherence and medication efects. Longer follow-up of healthcare use and mortality will determine if the increased adherence per se eventually will have a meaningful efect on patient health

Place, publisher, year, edition, pages
BioMed Central (BMC), 2021
National Category
Social and Clinical Pharmacy
Research subject
Biomedical Sciences, Pharmacology
Identifiers
urn:nbn:se:lnu:diva-101984 (URN)10.1186/s12872-021-02178-0 (DOI)000679833300001 ()34334142 (PubMedID)2-s2.0-85111998744 (Scopus ID)2021 (Local ID)2021 (Archive number)2021 (OAI)
Available from: 2021-04-07 Created: 2021-04-07 Last updated: 2023-04-17Bibliographically approved
Petersson, G. (2021). Hållbar digitalisering för hälsan. In: Göran Petersson;Martin Rydmark;Anders Thurin (Ed.), Medicinsk informatik: (pp. 430-443). Stockholm: Liber
Open this publication in new window or tab >>Hållbar digitalisering för hälsan
2021 (Swedish)In: Medicinsk informatik / [ed] Göran Petersson;Martin Rydmark;Anders Thurin, Stockholm: Liber, 2021, p. 430-443Chapter in book (Other academic)
Place, publisher, year, edition, pages
Stockholm: Liber, 2021
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Health and Caring Sciences, Health Informatics
Identifiers
urn:nbn:se:lnu:diva-98650 (URN)9789147134083 (ISBN)
Available from: 2020-10-26 Created: 2020-10-26 Last updated: 2021-04-16Bibliographically approved
Petersson, G., Rydmark, M. & Thurin, A. (Eds.). (2021). Medicinsk informatik. Stockholm: Liber
Open this publication in new window or tab >>Medicinsk informatik
2021 (Swedish)Collection (editor) (Other academic)
Place, publisher, year, edition, pages
Stockholm: Liber, 2021. p. 455
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Health and Caring Sciences, Health Informatics; Health and Caring Sciences; Health and Caring Sciences, Health Informatics
Identifiers
urn:nbn:se:lnu:diva-98658 (URN)978-91-47-13408-3 (ISBN)
Available from: 2020-10-27 Created: 2020-10-27 Last updated: 2022-10-04Bibliographically approved
Petersson, G., Rydmark, M. & Thurin, A. (2021). Medicinsk informatik i vård och kunskapsbildning. In: Göran Petersson;Martin Rydmark;Anders Thurin (Ed.), Medicinsk informatik: (pp. 12-33). Stockholm: Liber
Open this publication in new window or tab >>Medicinsk informatik i vård och kunskapsbildning
2021 (Swedish)In: Medicinsk informatik / [ed] Göran Petersson;Martin Rydmark;Anders Thurin, Stockholm: Liber, 2021, p. 12-33Chapter in book (Other academic)
Place, publisher, year, edition, pages
Stockholm: Liber, 2021
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Health and Caring Sciences, Health Informatics
Identifiers
urn:nbn:se:lnu:diva-98647 (URN)9789147134083 (ISBN)
Available from: 2020-10-26 Created: 2020-10-26 Last updated: 2021-04-16Bibliographically approved
Qvarfordt, M., Throfast, V., Petersson, G., Hammar, T. & Hellström, L. (2021). Web-based education of the elderly improves drug utilization literacy: a randomized controlled trial. Health Informatics Journal, 27(1), 1-15
Open this publication in new window or tab >>Web-based education of the elderly improves drug utilization literacy: a randomized controlled trial
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2021 (English)In: Health Informatics Journal, ISSN 1460-4582, E-ISSN 1741-2811, Vol. 27, no 1, p. 1-15Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to explore the effects of web-based education in the field of drug utilization on elderly individuals’ knowledge of, concerns about and self-assessed understanding of drug utilization. The 260 included participants were randomized to a control group or an intervention group. To assess drug utilization literacy, we used a questionnaire containing 20 multiple-choice questions on drug utilization and ten statements about drug utilization (to which participants graded their response using a Likert scale: two about common concerns and eight about their self-assessed understanding of drug utilization). The Beliefs about Medicines Questionnaire-General was also used. The intervention group scored higher on the knowledge questions (p < 0.001) and on six of the eight statements about self-assessed understanding of drug utilization at the first check after 2 weeks (p < 0.05). At a second check 6 months later, the difference remained for the knowledge questions, but there was no difference in self-assessed understanding of drug utilization between the groups. There were no differences in the concerns about drug utilization or beliefs about medication at any time. We conclude that a web-based education can improve drug utilization literacy in elderly individuals and might contribute to the safer use of medications.

Place, publisher, year, edition, pages
Sage Publications, 2021
Keywords
drug utilization literacy, e-learning, elderly, medication education, web-based education
National Category
Public Health, Global Health, Social Medicine and Epidemiology Health Care Service and Management, Health Policy and Services and Health Economy
Research subject
Health and Caring Sciences, Health Informatics
Identifiers
urn:nbn:se:lnu:diva-100373 (URN)10.1177/1460458220977585 (DOI)000645567000042 ()33446035 (PubMedID)2-s2.0-85099996979 (Scopus ID)2021 (Local ID)2021 (Archive number)2021 (OAI)
Funder
The Kamprad Family Foundation
Available from: 2021-01-21 Created: 2021-01-21 Last updated: 2023-04-20Bibliographically approved
Gottliebsen, K. & Petersson, G. (2020). Limited evidence of benefits of patient operated intelligent primary care triage tools: findings of a literature review. BMJ Health & Care Informatics, 27(1), 1-7, Article ID e100114.
Open this publication in new window or tab >>Limited evidence of benefits of patient operated intelligent primary care triage tools: findings of a literature review
2020 (English)In: BMJ Health & Care Informatics, E-ISSN 2632-1009, Vol. 27, no 1, p. 1-7, article id e100114Article, review/survey (Refereed) Published
Abstract [en]

Introduction There is consistent evidence that the workload in general practices is substantially increasing. The digitalisation of healthcare including the use of artificial intelligence has been suggested as a solution to this problem. We wanted to explore the features of intelligent online triage tools in primary care by conducting a literature review.

Method A systematic literature search strategy was formulated and conducted in the PubMed database and the Cochrane Library. Articles were selected according to inclusion/exclusion criteria. Results and data were systematically extracted and thematically analysed. 17 articles of that reported large multimethod studies or smaller diagnostic accuracy tests on clinical vignettes were included. Reviews and expert opinions were also considered.

Results There was limited evidence on the actual effects and performance of triage tools in primary care. Several aspects can guide further development: concepts of system design, system implementation and diagnostic performance. The most important findings were: a need to formulate evaluation guidelines and regulations; their assumed potential has not yet been met; a risk of increased or redistribution of workloads and the available symptom checker systems seem overly risk averse and should be tested in real-life settings.

Conclusion This review identified several features associated with the design and implementation of intelligent online triage tools in a primary care context, although most of the investigated systems seemed underdeveloped and offered limited benefits. Current online triage systems should not be used by individuals who have reasonable access to traditional healthcare. Systems used should be strictly evaluated and regulated like other medical products.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2020
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
Research subject
Health and Caring Sciences, Health Informatics
Identifiers
urn:nbn:se:lnu:diva-94805 (URN)10.1136/bmjhci-2019-100114 (DOI)000619865700011 ()32385041 (PubMedID)2-s2.0-85084721918 (Scopus ID)2020 (Local ID)2020 (Archive number)2020 (OAI)
Available from: 2020-05-18 Created: 2020-05-18 Last updated: 2021-05-06Bibliographically approved
Throfast, V., Hellström, L., Hovstadius, B., Petersson, G. & Ericson, L. (2019). e-Learning for the elderly on drug utilization: a pilot study. Health Informatics Journal, 25(2), 227-239
Open this publication in new window or tab >>e-Learning for the elderly on drug utilization: a pilot study
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2019 (English)In: Health Informatics Journal, ISSN 1460-4582, E-ISSN 1741-2811, Vol. 25, no 2, p. 227-239Article in journal (Refereed) Published
Abstract [en]

This study explores the attitudes of elderly people to the use of electronic educational technology (e-learning) on drug utilization, with particular emphasis on the layout, usability, content, and level of knowledge in the tool. e-Learning modules were evaluated by a group of elderly people (aged ⩾65 years, n = 16) via a questionnaire comprising closed and open-ended questions. Both qualitative and quantitative analyses of the responses showed mostly positive reviews. The results indicate that the e-learning modules are a suitable tool for distributing information and education and that they can be managed by elderly individuals who are familiar with computers, allowing them to learn more about medication use.

Place, publisher, year, edition, pages
Sage Publications, 2019
Keywords
aged, computer-assisted instruction, drug utilization, e-learning, education
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Health and Caring Sciences, Health Informatics
Identifiers
urn:nbn:se:lnu:diva-74242 (URN)10.1177/1460458217704245 (DOI)000468931800001 ()28464726 (PubMedID)2-s2.0-85065640411 (Scopus ID)
Available from: 2018-05-09 Created: 2018-05-09 Last updated: 2022-02-22Bibliographically approved
Stevenson-Ågren, J., Israelsson, J., Petersson, G. & Bath, P. (2018). Factors influencing the quality of vital signs data in electronic health records: a qualitative study. Journal of Clinical Nursing, 27(5-6), 1276-1286
Open this publication in new window or tab >>Factors influencing the quality of vital signs data in electronic health records: a qualitative study
2018 (English)In: Journal of Clinical Nursing, ISSN 0962-1067, E-ISSN 1365-2702, Vol. 27, no 5-6, p. 1276-1286Article in journal (Refereed) Published
Abstract [en]

Aims and objectives

To investigate reasons for inadequate documentation of vital signs in an electronic health record.

Background

Monitoring vital signs is crucial to detecting and responding to patient deterioration. The ways in which vital signs are documented in electronic health records have received limited attention in the research literature. A previous study revealed that vital signs in an electronic health record were incomplete and inconsistent.

Design

Qualitative study.

Methods

Qualitative study. Data were collected by observing (68 hr) and interviewing nurses (n = 11) and doctors (n = 3), and analysed by thematic analysis to examine processes for measuring, documenting and retrieving vital signs in four clinical settings in a 353-bed hospital.

Results

We identified two central reasons for inadequate vital sign documentation. First, there was an absence of firm guidelines for observing patients’ vital signs, resulting in inconsistencies in the ways vital signs were recorded. Second, there was a lack of adequate facilities in the electronic health record for recording vital signs. This led to poor presentation of vital signs in the electronic health record and to staff creating paper “workarounds.”

Conclusions

This study demonstrated inadequate routines and poor facilities for vital sign documentation in an electronic health record, and makes an important contribution to knowledge by identifying problems and barriers that may occur. Further, it has demonstrated the need for improved facilities for electronic documentation of vital signs.

Relevance to clinical practice

Patient safety may have been compromised because of poor presentation of vital signs. Thus, our results emphasised the need for standardised routines for monitoring patients. In addition, designers should consult the clinical end-users to optimise facilities for electronic documentation of vital signs. This could have a positive impact on clinical practice and thus improve patient safety.

Place, publisher, year, edition, pages
New Jersey: John Wiley & Sons, 2018
Keywords
Vital signs, patient safety, electronic health records
National Category
Other Medical Sciences not elsewhere specified
Research subject
Health and Caring Sciences, Health Informatics
Identifiers
urn:nbn:se:lnu:diva-70319 (URN)10.1111/jocn.14174 (DOI)000428419400087 ()29149483 (PubMedID)2-s2.0-85044258923 (Scopus ID)
Available from: 2018-01-31 Created: 2018-01-31 Last updated: 2024-01-11Bibliographically approved
Johansson Östbring, M., Eriksson, T., Petersson, G. & Hellström, L. (2018). Motivational Interviewing and Medication Review in Coronary Heart Disease (MIMeRiC): Intervention Development and Protocol for the Process Evaluation. JMIR Research Protocols, 7(1), 1-12, Article ID e21.
Open this publication in new window or tab >>Motivational Interviewing and Medication Review in Coronary Heart Disease (MIMeRiC): Intervention Development and Protocol for the Process Evaluation
2018 (English)In: JMIR Research Protocols, E-ISSN 1929-0748, Vol. 7, no 1, p. 1-12, article id e21Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Trials of complex interventions are often criticized for being difficult to interpret because the effects of apparently similar interventions vary across studies dependent on context, targeted groups, and the delivery of the intervention. The Motivational Interviewing and Medication Review in Coronary heart disease (MIMeRiC) trial is a randomized controlled trial (RCT) of an intervention aimed at improving pharmacological secondary prevention. Guidelines for the development and evaluation of complex interventions have recently highlighted the need for better reporting of the development of interventions, including descriptions of how the intervention is assumed to work, how this theory informed the process evaluation, and how the process evaluation relates to the outcome evaluation.

OBJECTIVE: This paper aims to describe how the intervention was designed and developed. The aim of the process evaluation is to better understand how and why the intervention in the MIMeRiC trial was effective or not effective.

METHODS: The research questions for evaluating the process are based on the conceptual model of change processes assumed in the intervention and will be analyzed by qualitative and quantitative methods. Quantitative data are used to evaluate the medication review in terms of drug-related problems, to describe how patients' beliefs about medicines are affected by the intervention, and to evaluate the quality of motivational interviewing. Qualitative data will be used to analyze whether patients experienced the intervention as intended, how cardiologists experienced the collaboration and intervention, and how the intervention affected patients' overall experience of care after coronary heart disease.

RESULTS: The development and piloting of the intervention are described in relation to the theoretical framework. Data for the process evaluation will be collected until March 2018. Some process evaluation questions will be analyzed before, and others will be analyzed after the outcomes of the MIMeRiC RCT are known.

CONCLUSIONS: This paper describes the framework for the design of the intervention tested in the MIMeRiC trial, development of the intervention from the pilot stage to the complete trial intervention, and the framework and methods for the process evaluation. Providing the protocol of the process evaluation allows prespecification of the processes that will be evaluated, because we hypothesize that they will determine the outcomes of the MIMeRiC trial. This protocol also constitutes a contribution to the new field of process evaluations as made explicit in health services research and clinical trials of complex interventions.

Place, publisher, year, edition, pages
JMIR Publications, 2018
Keywords
coronary artery disease, quality of health care, medication adherence, medication therapy management, pharmacist
National Category
Social and Clinical Pharmacy
Research subject
Biomedical Sciences, Pharmacology
Identifiers
urn:nbn:se:lnu:diva-71384 (URN)10.2196/resprot.8660 (DOI)000432915700019 ()29382630 (PubMedID)2-s2.0-85102335706 (Scopus ID)
Available from: 2018-03-06 Created: 2018-03-06 Last updated: 2024-01-17Bibliographically approved
Johansson Östbring, M., Eriksson, T., Petersson, G. & Hellström, L. (2018). Motivational Interviewing and Medication Review in Coronary Heart Disease (MIMeRiC): Protocol for a Randomized Controlled Trial Investigating Effects on Clinical Outcomes, Adherence, and Quality of Life. JMIR Research Protocols, 7(2), 1-15, Article ID e57.
Open this publication in new window or tab >>Motivational Interviewing and Medication Review in Coronary Heart Disease (MIMeRiC): Protocol for a Randomized Controlled Trial Investigating Effects on Clinical Outcomes, Adherence, and Quality of Life
2018 (English)In: JMIR Research Protocols, E-ISSN 1929-0748, Vol. 7, no 2, p. 1-15, article id e57Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Preventive treatment goals for blood pressure and cholesterol levels continue to be unmet for many coronary patients. The effect of drug treatment depends on both its appropriateness and the patients' adherence to the treatment regimen. There is a need for adherence interventions that have a measurable effect on clinical outcomes.

OBJECTIVE: This study aims to evaluate the effects on treatment goals of an intervention designed to improve patient adherence and treatment quality in secondary prevention of coronary heart disease. A protocol for the prespecified process evaluation of the trial is published separately.

METHODS: The Motivational Interviewing and Medication Review in Coronary heart disease (MIMeRiC) trial is a prospective, randomized, outcomes-blinded trial designed to compare individualized follow-up by a clinical pharmacist using motivational interviewing (MI) and medication review with standard follow-up. Patients were randomized to 2 groups after stratification according to their beliefs about medicines. After standard follow-up at the cardiology clinic, patients in the intervention group are seen individually by a clinical pharmacist 2 to 5 times as required over 7 months, at the clinic. The pharmacist reviews each patient's medication and uses MI to manage any problems with prescribing and adherence. The primary study outcome is the proportion of patients who have reached the treatment goal for low-density lipoprotein cholesterol by 12 months after discharge. Secondary outcomes are the effects on patient adherence, systolic blood pressure, disease-specific quality of life, and health care use.

RESULTS: The protocol for this study was approved by the Regional Ethics Committee, Linköping, in 2013. Enrollment started in October 2013 and ended in December 2016 when 417 patients had been included. Follow-up data collection will conclude in March 2018. Publication of the primary and secondary outcome results from the MIMeRiC trial is anticipated in 2019.

CONCLUSIONS: The MIMeRiC trial will assess the effectiveness of an intervention involving medication reviews and individualized support. The results will inform the continued development of support for this large group of patients who use preventive medicines for lifelong treatment. The design of this adherence intervention is based on a theoretical framework and is the first trial of an intervention that uses beliefs about medicines to individualize the intervention protocol.

TRIAL REGISTRATION: ClinicalTrials.gov NCT02102503; https://clinicaltrials.gov/ct2/show/NCT02102503 (Archived by WebCite at http://www.webcitation.org/6x7iUDohy).

Place, publisher, year, edition, pages
JMIR Publications, 2018
Keywords
coronary artery disease, medication adherence, medication therapy management, pharmacist, randomized controlled trial
National Category
Social and Clinical Pharmacy
Research subject
Biomedical Sciences, Pharmacology
Identifiers
urn:nbn:se:lnu:diva-71385 (URN)10.2196/resprot.8659 (DOI)000432916000005 ()29463490 (PubMedID)2-s2.0-85083208653 (Scopus ID)
Funder
The Kamprad Family Foundation
Available from: 2018-03-06 Created: 2018-03-06 Last updated: 2024-01-17Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-4295-7201

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