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Gierow, Peter
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Publications (10 of 42) Show all publications
Johansson, O., Gierow, P. & Morgan, P. (2019). Trends in Swedish Contact Lens Prescribing 2017. In: Trends in Swedish Contact Lens Prescribing 2017: . Paper presented at European Academy of Optometry.
Open this publication in new window or tab >>Trends in Swedish Contact Lens Prescribing 2017
2019 (English)In: Trends in Swedish Contact Lens Prescribing 2017, 2019Conference paper, Poster (with or without abstract) (Other academic)
Abstract [en]

Poster display 2: TRENDS IN SWEDISH CONTACT LENS PRESCRIBING 2017

Presenter: Oskar Johansson

Authors: OSKAR JOHANSSON1 , PHILP MORGAN2 , PETER GIEROW1

Affiliation:1) Linnaeus University 2) University of Manchester

Key words: Contact lens, fitting, lens type

Purpose: The purpose was to evaluate the trends of contact lens prescribing among Swedish optometrists in 2017.

Methods: A standardized survey form developed by Morgan er al. was distributed to Swedish optometrists usingtheir professional organizations, optometry chains, direct email, and by hand directly. They were asked to fill out theform for the next ten contact lens patients after receiving the survey. Information was collected regarding the dayof fitting, age, sex, lens material, design, frequency of replacement, wear frequency, modality and type of caresystem. A weighting system is employed to account for the volume of activity undertaken by the respondents,calculated by the time period required to achieve 10 fits. All the forms and data were analyzed at the University of Manchester.

Results: 57 forms were returned, including 562 fits. The mean age of the patients was 37 yrs, and 65 % were female.83 % were fitted for full-time wear and 27 % were managed as new fits. Soft contact lenses is the most fitted modalityand represents 97.8 % of all new fits and 93.6 % of all refits. Rigid contact lens fits represents therefore in grand total5.3 % with 2.2 % of the new fits and 6.4 % of the refits. About two-thirds of soft lenses prescribed were siliconehydrogels. Of the different designs, spherical lenses were most widely fitted, with toric lenses on at least one eyecoming right after. Extended wear accounts for 10.6 % of the fittings. Multi-purpose solutions were the most popularregimen prescribed at 99.4 %.

Conclusions: When compared with data from Norway and Denmark, it is evident that daily disposables are morepopular in these countries (74 %), whereas in Sweden it is monthly replacements (58 %). Otherwise, the results aresimilar to what has been reported from other parts of the world.

National Category
Ophthalmology
Research subject
Natural Science, Optometry
Identifiers
urn:nbn:se:lnu:diva-85197 (URN)
Conference
European Academy of Optometry
Available from: 2019-06-12 Created: 2019-06-12 Last updated: 2019-06-12
Johansson, O., Gierow, P. & Morgan, P. (2019). TRENDS IN SWEDISH CONTACT LENS PRESCRIBING 2017. Scandinavian Journal of Optometry and Visual Science, 12(01)
Open this publication in new window or tab >>TRENDS IN SWEDISH CONTACT LENS PRESCRIBING 2017
2019 (English)In: Scandinavian Journal of Optometry and Visual Science, ISSN 1891-0882, E-ISSN 1891-0890, Vol. 12, no 01Article in journal (Other academic) Published
Abstract [en]

Background: The purpose was to evaluate the trends of contact lens prescribing among Swedish optometrists in 2017.

Materials and Methods: A standardized survey form was distributed to Swedish optometrists using their professional organisations, optometry chains, direct email, and by hand directly. They were asked to fill out the form for the ten contact lens fits performed after receipt of the survey form. Information was collected regarding age and sex of patient, fit/refit, lens design and material, modality and solution prescribed.

Results: 57 forms were returned detailing 562 fits. The mean age of the patients was 37 yrs, and 65 % were female. 83 % were fitted for full-time wear and 27 % were managed as new fits. 94.7 % were soft contact lens fits and silicone hydrogel was the dominating material.

Conclusions: When compared with data from Norway and Denmark, it is evident that daily disposables are more popular in these countries (74 %), whereas in Sweden it is monthly replacements (58 %). Otherwise, the results are similar to what has been reported from other parts of the world.

Keywords
contact lens, Sweden, prescribing trends, survey
National Category
Ophthalmology
Identifiers
urn:nbn:se:lnu:diva-86853 (URN)10.5384/sjovs.vol12i1p5-7 (DOI)
Available from: 2019-07-15 Created: 2019-07-15 Last updated: 2019-07-15
Gierow, P. & Kacz, L. (2018). Effect of Age and Gender on Dry Eye according to Tests and Symptoms. Paper presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), APR 29-MAY 03, 2018, Honolulu, HI. Investigative Ophthalmology and Visual Science, 59(9)
Open this publication in new window or tab >>Effect of Age and Gender on Dry Eye according to Tests and Symptoms
2018 (English)In: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 59, no 9Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2018
National Category
Ophthalmology
Research subject
Natural Science, Optometry
Identifiers
urn:nbn:se:lnu:diva-78424 (URN)000442932802004 ()
Conference
Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), APR 29-MAY 03, 2018, Honolulu, HI
Available from: 2018-10-22 Created: 2018-10-22 Last updated: 2018-10-22Bibliographically approved
Boström, J., Pettersson, L., Baskaran, K., Källmark, F. & Gierow, P. (2016). Meibography: Inter-rater reliability. In: 8th International Conference on the Tear Film & Ocular Surface: Basic Science and Clinical Relevance: Conference Program & Abstract Book. Paper presented at TFOS 2016, September 7-10, 2016, Montpellier, France (pp. 47).
Open this publication in new window or tab >>Meibography: Inter-rater reliability
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2016 (English)In: 8th International Conference on the Tear Film & Ocular Surface: Basic Science and Clinical Relevance: Conference Program & Abstract Book, 2016, p. 47-Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Purpose. The tear film lipid layer holds an important role in maintaining the integrity and health of the anterior surface of the eye. The meibomian glands found in eyelids are responsible for producing most of the lipids of the tear film. Dysfunction of the meibomian glands leads to increased evaporation of tears, which may lead to dry eye. Meibography is a method used for assessing the drop out of meibomian glands. The aim of this study was to evaluate the reliability between two different examiners when rating meibography images. Methods. The Sirius 3D scheimpflug camera (C.S.O., Florence, Italy) was used to photograph the everted upper and lower eyelids of the right and left eye of 52 subjects. The grade of meibomian gland loss was subjectively graded using the five-grade Meiboscale (Pult, 2012) and the percentage of gland loss was calculated using Phoenix Meibography software (version 3.0.1.021, bon Optic VertriebsGmbH, Lübeck, Germany). Data was analyzed using MedCalc for Windows (version 16.4.3, MedCalc Software, Ostend, Belgium). Results. The inter-rater reliability for the Meiboscale grade of meibomian gland loss was calculated using weighted Cohen’s kappa (linear weights). The result for all 208 images was Kw = 0.542 (95 % CI 0.454 to 0.630), which indicates a moderate agreement. The inter-rater reliability for the percentage of meibomian gland loss was calculated using intraclass correlation coefficient. The result for all 208 images was ICC = 0.794 (95 % CI 0.737 to 0.839), which indicates a substantial agreement. Conclusions. Imaging is an invaluable tool when managing patients in clinical practice. When performing meibography to evaluate meibomian gland loss, using software to calculate the percentage of gland loss gives a better inter-rater agreement than subjective grading of the images.

National Category
Ophthalmology
Research subject
Natural Science, Optometry
Identifiers
urn:nbn:se:lnu:diva-74519 (URN)
Conference
TFOS 2016, September 7-10, 2016, Montpellier, France
Available from: 2018-05-24 Created: 2018-05-24 Last updated: 2018-12-07Bibliographically approved
Gierow, P., Larsson, N. & Boström, J. (2015). Comparison oF Different Tests for Evaluation of the Meibomian Glands. Paper presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), MAY 03-07, 2015, Denver, CO. Investigative Ophthalmology and Visual Science, 56(7)
Open this publication in new window or tab >>Comparison oF Different Tests for Evaluation of the Meibomian Glands
2015 (English)In: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 56, no 7Article in journal, Meeting abstract (Other academic) Published
National Category
Ophthalmology
Research subject
Natural Science, Optometry
Identifiers
urn:nbn:se:lnu:diva-47384 (URN)000362891103257 ()
Conference
Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), MAY 03-07, 2015, Denver, CO
Available from: 2015-11-24 Created: 2015-11-24 Last updated: 2017-12-01Bibliographically approved
Carlsson, S. K. & Gierow, P. (2012). p38 mitogen-activated protein kinase modulates exocrine secretion in rabbit lacrimal gland. Cellular & Molecular Biology Letters (Druk), 17(1), 1-10
Open this publication in new window or tab >>p38 mitogen-activated protein kinase modulates exocrine secretion in rabbit lacrimal gland
2012 (English)In: Cellular & Molecular Biology Letters (Druk), ISSN 1425-8153, E-ISSN 1689-1392, Vol. 17, no 1, p. 1-10Article in journal (Refereed) Published
Abstract [en]

The lacrimal gland (LG) is an exocrine gland important for secretion of the tear film. The kinase p38 has important signal transduction functions, e.g. in gene transcription, but has previously not been known to modulate exocrine secretion. The aim of the current study was to investigate the role of p38 in carbachol (Cch)-induced LG secretion in LG acinar cells in vitro. Western blotting was used to determine the phosphorylation status of p38 and p42/44 and determine expression of p38 isoforms. To determine the effect of p38 inhibition on LG secretion, PD 169316, a general p38 inhibitor, and SB 239063, an inhibitor of p38α and β, were added to the cells prior to secretion measurements. The results revealed activation of p38 mediated by Cch stimulation and inhibition of Cch-induced secretion as a result of p38 inhibition. The inhibition was observed with PD 169316 isoforms, but not with SB 239063. The p38δ isoform was shown to have robust expression both by Western blotting of acinar cells and immunofluorescence of the whole gland. In conclusion, p38 activation mediates secretion in cholinergic stimulation of rabbit LG cells.

Keywords
lacirmal gland, p38, secretion, acetylcholine
National Category
Cell Biology
Research subject
Natural Science, Biomedical Sciences
Identifiers
urn:nbn:se:lnu:diva-15968 (URN)10.2478/s11658-011-0031-y (DOI)000298651800001 ()2-s2.0-84859897195 (Scopus ID)
Available from: 2011-12-07 Created: 2011-12-07 Last updated: 2018-02-19Bibliographically approved
Carlsson, S. K., Edman, M., Delbro, D. & Gierow, P. (2010). Adenosine A2 receptor presence, and synergy with cholinergic stimulation in rabbit lacrimal gland. Current Eye Research, 35(6), 466-474
Open this publication in new window or tab >>Adenosine A2 receptor presence, and synergy with cholinergic stimulation in rabbit lacrimal gland
2010 (English)In: Current Eye Research, ISSN 0271-3683, E-ISSN 1460-2202, Vol. 35, no 6, p. 466-474Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Secretion from the lacrimal gland is an important part of the well-being of the eye, and a central part in the search for treatment of dry eye syndrome. Adenosine has stimulatory effects on the lacrimal gland, and can potentiate the effect of the cholinergic agonist carbachol (Cch). The aim of the present study is to investigate the presence of the adenosine A(2) receptor subtypes A(2A) and A(2B) in the rabbit lacrimal gland, and to characterize their role in regulated acinar cell secretion.

METHODS: Expression of the receptors was investigated using reverse transcriptase-PCR (RT-PCR) and immunofluorescence, and secretion effects were studied using a secretion assay in isolated lacrimal gland acinar cells.

RESULTS: Presence of both receptors was detected by RT-PCR and immunofluorescence. The secretion assay revealed a minor effect of stimulation of the A(2) receptors, and a strong synergistic effect with the cholinergic agonist Cch. The synergistic effect was significantly reduced by the A(2B) antagonist PSB 1115, but not by the A(2A) antagonist SCH 58261, indicating that A(2B) is the receptor responsible for this potentiation.

CONCLUSIONS: The study reveals the presence of the adenosine A(2) receptor subtypes as well as a role for them in lacrimal gland secretion, and especially in the synergy with purinergic and cholinergic stimulation.

National Category
Natural Sciences
Research subject
Natural Science, Biomedical Sciences
Identifiers
urn:nbn:se:lnu:diva-7814 (URN)20465439 (PubMedID)
Available from: 2010-08-26 Created: 2010-08-26 Last updated: 2017-12-12Bibliographically approved
Bergmanson, J. P. & Gierow, P. (2009). The Lacrimal System (16ed.). In: JPG Bergmanson (Ed.), Clinical Ocular Anatomy and Physiology (pp. 43-56). Houston, TX, USA: University of Houston Texas Eye Research and Technology Center
Open this publication in new window or tab >>The Lacrimal System
2009 (English)In: Clinical Ocular Anatomy and Physiology / [ed] JPG Bergmanson, Houston, TX, USA: University of Houston Texas Eye Research and Technology Center , 2009, 16, p. 43-56Chapter in book (Other academic)
Place, publisher, year, edition, pages
Houston, TX, USA: University of Houston Texas Eye Research and Technology Center, 2009 Edition: 16
National Category
Medical and Health Sciences
Research subject
Natural Science, Biomedical Sciences; Natural Science, Optometry
Identifiers
urn:nbn:se:lnu:diva-4270 (URN)9780980070811 (ISBN)
Available from: 2010-04-27 Created: 2010-04-27 Last updated: 2012-01-11Bibliographically approved
Edman, M., Andersson, S., Delbro, D. & Gierow, P. (2008). Functional expression of the adenosine A1 receptor in rabbit lacrimal gland.. Experimental Eye Research, 86(1), 110-117
Open this publication in new window or tab >>Functional expression of the adenosine A1 receptor in rabbit lacrimal gland.
2008 (English)In: Experimental Eye Research, ISSN 0014-4835, E-ISSN 1096-0007, Vol. 86, no 1, p. 110-117Article in journal (Refereed) Published
National Category
Natural Sciences
Research subject
Natural Science, Biomedical Sciences; Natural Science, Optometry; Natural Science, Biochemistry
Identifiers
urn:nbn:se:lnu:diva-1799 (URN)
Available from: 2010-04-06 Created: 2010-04-06 Last updated: 2017-12-12Bibliographically approved
Andersson, S., Edman, M., Bekmezian, A., Holmberg, J., Mircheff, A. K. & Gierow, P. (2006). Characterization of beta-hexosaminidase secretion in rabbit lacrimal gland. Experimental eye research, 83(5), 1081-1088
Open this publication in new window or tab >>Characterization of beta-hexosaminidase secretion in rabbit lacrimal gland
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2006 (English)In: Experimental eye research, Vol. 83, no 5, p. 1081-1088Article in journal (Refereed) Published
National Category
Natural Sciences
Research subject
Natural Science, Biomedical Sciences; Natural Science, Optometry
Identifiers
urn:nbn:se:lnu:diva-669 (URN)
Available from: 2010-04-01 Created: 2010-04-01 Last updated: 2011-10-04Bibliographically approved
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