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Suriyanarayanan, Subramanian
Publications (8 of 8) Show all publications
Suriyanarayanan, S., Mandal, S., Ramanujam, K. & Nicholls, I. A. (2017). Electrochemically synthesized molecularly imprinted polythiophene nanostructures as recognition elements for an aspirin-chemosensor. Sensors and actuators. B, Chemical, 253, 428-436
Open this publication in new window or tab >>Electrochemically synthesized molecularly imprinted polythiophene nanostructures as recognition elements for an aspirin-chemosensor
2017 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 253, p. 428-436Article in journal (Refereed) Published
Abstract [en]

A chemosensor utilizing electro-polymerized film, as recognition element, has been devised and tested for selective determination of aspirin. The sensor consists of molecularly imprinted polymer (MIP) recognition elements electrodeposited as polymeric nanowires on gold-coated quartz resonator. A nano structures were prepared by electrochemical co-polymerization of the preformed complex between the template, aspirin, the functional monomers, 3-thienylboronic acid (3-TBA) and 3-thiopheneacetic acid (3-TAA), and thiophene, which was employed as a cross-linker. This nanostructure upon leaching aspirin serve as MIP. Polymerizations were performed in acetonitrile (MIP-org) as well as a micelle forming medium (MIP-mic). For MIP nanowire (MIP-ano) synthesis, sacrificial alumina templates were used during electro-polymerization in acetonitrile. Scanning electron microscope studies revealed compactly arranged polythiophene nanowires of uniform thickness in MIP-ano film, and MIP-mic film produced aggregated micron sized polymer structures. Density functional theoretical studies indicated a stable hydrogen bond-based complexation of aspirin by 3-TBA and 3-TAA in the pre-polymerization mixture implying that the MIP film thus prepared could selectively rebind the aspirin template. The MIP-ano-based chemosensor was sensitive towards aspirin (0.5-10 mM), over clinically relevant range (0.15-0.5 mM) under optimized FIA conditions. The sensitivity (20.62 Hz/mM) of the MIP-ano was eight and fifteen times higher than the MIP-mic (2.80 Hz/mM) and MIP-org (1.10 Hz/mM). Notably, the sensor selectively discriminates aspirin from structurally or functionally related interferants and metabolites, such as, salicylic acid, acetylsalicyloyl chloride and ibuprofen. (C) 2017 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2017
Keyword
Electrochemical polymerization, Aspirin chemosensor, Quartz crystal microbalance, Sacrificial template
National Category
Organic Chemistry
Research subject
Chemistry, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-68574 (URN)10.1016/j.snb.2017.05.076 (DOI)000411124800051 ()
Available from: 2017-11-02 Created: 2017-11-02 Last updated: 2017-11-02Bibliographically approved
Nicholls, I. A., Chavan, S., Golker, K., Karlsson, B. C. G., Olsson, G. D., Rosengren, A. M., . . . Wiklander, J. G. (2015). Theoretical and Computational Strategies for the Study of the Molecular Imprinting Process and Polymer Performance. In: Mattiasson, B. & Ye, L. (Ed.), Molecularly Imprinted Polymers in Biotechnology: (pp. 25-50). Berlin: Springer
Open this publication in new window or tab >>Theoretical and Computational Strategies for the Study of the Molecular Imprinting Process and Polymer Performance
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2015 (English)In: Molecularly Imprinted Polymers in Biotechnology / [ed] Mattiasson, B. & Ye, L., Berlin: Springer, 2015, p. 25-50Chapter in book (Refereed)
Abstract [en]

The development of in silico strategies for the study of the molecular imprinting process and the properties of molecularly imprinted materials has been driven by a growing awareness of the inherent complexity of these systems and even by an increased awareness of the potential of these materials for use in a range of application areas. Here we highlight the development of theoretical and computational strategies that are contributing to an improved understanding of the mechanisms underlying molecularly imprinted material synthesis and performance, and even their rational design.

Place, publisher, year, edition, pages
Berlin: Springer, 2015
Series
Advances in Biochemical Engineering-Biotechnology, ISSN 0724-6145 ; 150
National Category
Polymer Technologies
Research subject
Chemistry, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-42600 (URN)10.1007/10_2015_318 (DOI)000365222300003 ()2-s2.0-84938411248 (Scopus ID)978-3-319-20729-2 (ISBN)978-3-319-20728-5 (ISBN)
Available from: 2015-04-15 Created: 2015-04-15 Last updated: 2017-02-17Bibliographically approved
Elmlund, L., Söderberg, P., Suriyanarayanan, S. & Nicholls, I. A. (2014). A Phage Display Screening Derived Peptide with Affinity for the Adeninyl Moiety. Biosensors, 4(2), 137-149
Open this publication in new window or tab >>A Phage Display Screening Derived Peptide with Affinity for the Adeninyl Moiety
2014 (English)In: Biosensors, ISSN 2079-6374, Vol. 4, no 2, p. 137-149Article in journal (Refereed) Published
Abstract [en]

Phage display screening of a surface-immobilized adenine derivative led to the identification of a heptameric peptide with selectivity for adenine as demonstrated through quartz crystal microbalance (QCM) studies. The peptide demonstrated a concentration dependent affinity for an adeninyl moiety decorated surface (KD of 968 ± 53.3 μM), which highlights the power of piezoelectric sensing in the study of weak interactions. 

National Category
Biochemistry and Molecular Biology
Research subject
Chemistry, Biochemistry
Identifiers
urn:nbn:se:lnu:diva-37248 (URN)10.3390/bios4020137 (DOI)2-s2.0-84902317201 (Scopus ID)
Available from: 2014-09-24 Created: 2014-09-24 Last updated: 2017-12-05Bibliographically approved
Elmlund, L., Suriyanarayanan, S., Wiklander, J. G., Aastrup, T. & Nicholls, I. A. (2014). Biotin selective polymer nano-films. Journal of Nanobiotechnology, 12, Article ID 8.
Open this publication in new window or tab >>Biotin selective polymer nano-films
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2014 (English)In: Journal of Nanobiotechnology, ISSN 1477-3155, E-ISSN 1477-3155, Vol. 12, article id 8Article in journal (Refereed) Published
Abstract [en]

Background: The interaction between biotin and avidin is utilized in a wide range of assay and diagnostic systems. A robust material capable of binding biotin should offer scope in the development of reusable assay materials and biosensor recognition elements. Results: Biotin-selective thin (3-5 nm) films have been fabricated on hexadecanethiol self assembled monolayer (SAM) coated Au/quartz resonators. The films were prepared based upon a molecular imprinting strategy where N, N'-methylenebisacrylamide and 2-acrylamido-2-methylpropanesulfonic acid were copolymerized and grafted to the SAM-coated surface in the presence of biotin methyl ester using photoinitiation with physisorbed benzophenone. The biotinyl moiety selectivity of the resonators efficiently differentiated biotinylated peptidic or carbohydrate structures from their native counterparts. Conclusions: Molecularly imprinted ultra thin films can be used for the selective recognition of biotinylated structures in a quartz crystal microbalance sensing platform. These films are stable for periods of at least a month. This strategy should prove of interest for use in other sensing and assay systems.

Keyword
Molecularly imprinted polymer, Biotinylated compounds, Photoinitiated graft co-polymerization, Quartz crystal microbalance (QCM) sensors, Sandwich-casting method
National Category
Organic Chemistry
Research subject
Chemistry, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-34479 (URN)10.1186/1477-3155-12-8 (DOI)000335075000001 ()2-s2.0-84899157003 (Scopus ID)
Available from: 2014-05-28 Created: 2014-05-28 Last updated: 2017-12-05Bibliographically approved
Suriyanarayanan, S., Nawaz, H., Ndizeye, N. & Nicholls, I. A. (2014). Hierarchical Thin Film Architectures for Enhanced Sensor Performance: Liquid Crystal-Mediated Electrochemical Synthesis of Nanostructured Imprinted Polymer Films for the Selective Recognition of Bupivacaine. Biosensors, 4(2), 90-110
Open this publication in new window or tab >>Hierarchical Thin Film Architectures for Enhanced Sensor Performance: Liquid Crystal-Mediated Electrochemical Synthesis of Nanostructured Imprinted Polymer Films for the Selective Recognition of Bupivacaine
2014 (English)In: Biosensors, ISSN 2079-6374, Vol. 4, no 2, p. 90-110Article in journal (Refereed) Published
Abstract [en]

Nanostructured bupivacaine-selective molecularly imprinted 3-aminophenylboronic acid-p-phenylenediamine co-polymer (MIP) films have been prepared on gold-coated quartz (Au/quartz) resonators by electrochemical synthesis under cyclic voltammetric conditions in a liquid crystalline (LC) medium (triton X-100/water). Films prepared in water and in the absence of template were used for control studies. Infrared spectroscopic studies demonstrated comparable chemical compositions for LC and control polymer films. SEM studies revealed that the topologies of the molecularly imprinted polymer films prepared in the LC medium (LC-MIP) exhibit discernible 40 nm thick nano-fiber structures, quite unlike the polymers prepared in the absence of the LC-phase. The sensitivity of the LC-MIP in a quartz crystal microbalance (QCM) sensor platform was 67.6 ± 4.9 Hz/mM under flow injection analysis (FIA) conditions, which was ≈250% higher than for the sensor prepared using the aqueous medium. Detection was possible at 100 nM (30 ng/mL), and discrimination of bupivacaine from closely related structural analogs was readily achieved as reflected in the corresponding stability constants of the MIP-analyte complexes. The facile fabrication and significant enhancement in sensor sensitivity together highlight the potential of this LC-based imprinting strategy for fabrication of polymeric materials with hierarchical architectures, in particular for use in surface-dependent application areas, e.g., biomaterials or sensing.

Keyword
bupivacaine, electropolymerization, liquid crystal, molecularly imprinted polymer, nanostructured polymer films, piezoelectric sensor, quartz crystal microbalance
National Category
Materials Chemistry
Research subject
Chemistry, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-42605 (URN)10.3390/bios4020090 (DOI)2-s2.0-84902329632 (Scopus ID)
Funder
Swedish Research CouncilKnowledge Foundation
Available from: 2015-04-15 Created: 2015-04-15 Last updated: 2017-12-04Bibliographically approved
Suriyanarayanan, S., Petrone, L., Ederth, T. & Nicholls, I. A. (2013). Biotinyl moiety-selective polymer films with highly ordered macropores. Chemical Communications, 49(46), 5274-5276
Open this publication in new window or tab >>Biotinyl moiety-selective polymer films with highly ordered macropores
2013 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 49, no 46, p. 5274-5276Article in journal (Refereed) Published
Abstract [en]

Macroporous polymer films with long-range uniformity and biotinyl-moiety selective recognition sites have been developed. A hierarchical molecular imprinting strategy afforded significant enhancements in quartz crystal microbalance (QCM) sensitivities towards biotinylated compounds.

National Category
Organic Chemistry
Research subject
Chemistry, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-27571 (URN)10.1039/c3cc42235f (DOI)000318917900009 ()2-s2.0-84877767181 (Scopus ID)
Available from: 2013-07-17 Created: 2013-07-17 Last updated: 2017-12-06Bibliographically approved
Suriyanarayanan, S., Lee, H.-H., Liedberg, B., Aastrup, T. & Nicholls, I. A. (2013). Protein-resistant hyperbranched polyethyleneimine brush surfaces. Journal of Colloid and Interface Science, 396, 307-315
Open this publication in new window or tab >>Protein-resistant hyperbranched polyethyleneimine brush surfaces
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2013 (English)In: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 396, p. 307-315Article in journal (Refereed) Published
Abstract [en]

A novel hyperbranched polyethyleneimine (PEI) modified gold surface has been designed, fabricated, and investigated with respect to its ability to resist non-specific adsorption of proteins. The facile synthesis strategy, based on self-assembly, involves immobilization of polyethyleneimine to gold surfaces modified with 11-mercaptoundecanoic acid (MuDA) monolayers using traditional carbodiimide chemistry. The hyperbranched polymer brushes were characterized by X-ray photoelectron spectroscopy (XPS). Reflection absorption infrared spectroscopy (RAIRS) and ellipsometry measurements showed the thickness of the PEI brushes increases with adsorption solution ionic strength. Polymer brush surface concentrations can be improved from 2560 to 3880 chains/mu m(2) by changing the ionic strength of the adsorption solution (PBS) by varying NaCl concentration from 0 to 650 mM. Protein adsorption (pH 7.4) was evaluated under flow injection analysis (FIA) conditions using a quartz crystal microbalance (QCM). The PEI brushes suppress protein adsorption, for example, cytochrome C, bovine serum albumin (BSA), and ribonuclease A, to less than 0.08 mu g/cm(2) and the protein resistance increases with increasing ionic strength of the carrier solution, performance comparable to that achieved with comparable PEG-coated surfaces. The PEI brushes were exceptionally stable, with adsorption characteristics maintained after 6 months storage in aqueous conditions (pH 7.4, 25 degrees C, PBS). The potential of hyperbranched PEI structures as protein-resistant surfaces is discussed. (C) 2013 Elsevier Inc. All rights reserved.

Keyword
Protein-resistant surfaces, Polyethyleneimine, Quartz crystal microbalance, Self-assembly, Ionic strength
National Category
Organic Chemistry
Research subject
Chemistry, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-25528 (URN)10.1016/j.jcis.2012.12.076 (DOI)000316372400041 ()2-s2.0-84875425508 (Scopus ID)
Available from: 2013-05-06 Created: 2013-05-06 Last updated: 2017-12-06Bibliographically approved
Elmlund, L., Suriyanarayanan, S., Wiklander, J. & Nicholls, I. A.Simple Strategy for Steering Polymer Film Formation on QCM Sensor Surfaces.
Open this publication in new window or tab >>Simple Strategy for Steering Polymer Film Formation on QCM Sensor Surfaces
(English)Manuscript (preprint) (Other academic)
National Category
Analytical Chemistry
Research subject
Natural Science, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-37250 (URN)
Available from: 2014-10-07 Created: 2014-09-24 Last updated: 2015-04-16Bibliographically approved
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