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Sundberg, Mark
Publications (10 of 21) Show all publications
Vikhorev, P., Vikhoreva, N., Sundberg, M., Balaz, M., Torres, N. A., Bunk, R., . . . Månsson, A. (2008). Diffusion dynamics of motor driven transport: gradient production and self-organization of surfaces.. Langmuir, 24(23), 13509-13517
Open this publication in new window or tab >>Diffusion dynamics of motor driven transport: gradient production and self-organization of surfaces.
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2008 (English)In: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 24, no 23, p. 13509-13517Article in journal (Refereed) Published
Abstract [en]

The interaction between cytoskeletal filaments (e.g., actin filaments) and molecular motors (e.g., myosin) is the basis for many aspects of cell motility and organization of the cell interior. In the in vitro motility assay (IVMA), cytoskeletal filaments are observed while being propelled by molecular motors adsorbed to artificial surfaces (e.g., in studies of motor function). Here we integrate ideas that cytoskeletal filaments may be used as nanoscale templates in nanopatterning with a novel approach for the production of surface gradients of biomolecules and nanoscale topographical features. The production of such gradients is challenging but of increasing interest (e.g., in cell biology). First, we show that myosin-induced actin filament sliding in the IVMA can be approximately described as persistent random motion with a diffusion coefficient D) given by a relationship analogous to the Einstein equation (D = kT/gamma). In this relationship, the thermal energy (kT) and the drag coefficient (gamma) are substituted by a parameter related to the free-energy transduction by actomyosin and the actomyosin dissociation rate constant, respectively. We then demonstrate how the persistent random motion of actin filaments can be exploited in conceptually novel methods for the production of actin filament density gradients of predictable shapes. Because of regularly spaced binding sites (e.g., lysines and cysteines) the actin filaments act as suitable nanoscale scaffolds for other biomolecules (tested for fibronectin) or nanoparticles. This forms the basis for secondary chemical and topographical gradients with implications for cell biological studies and biosensing.

National Category
Natural Sciences
Research subject
Natural Science, Biomedical Sciences
Identifiers
urn:nbn:se:lnu:diva-1858 (URN)10.1021/la8016112 (DOI)000261216500043 ()
Available from: 2010-04-06 Created: 2010-04-06 Last updated: 2017-12-12Bibliographically approved
Sundberg, M., Månsson, A. & Tågerud, S. (2007). Contact angle measurements by confocal microscopy for non-destructive microscale surface characterization. Journal of Colloid and Interface Science, 313, 454-460
Open this publication in new window or tab >>Contact angle measurements by confocal microscopy for non-destructive microscale surface characterization
2007 (English)In: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 313, p. 454-460Article in journal (Refereed) Published
National Category
Natural Sciences
Research subject
Natural Science, Biomedical Sciences; Biomedical Sciences, Pharmacology
Identifiers
urn:nbn:se:lnu:diva-2223 (URN)
Available from: 2010-04-07 Created: 2010-04-07 Last updated: 2017-12-12Bibliographically approved
Balaz, M., Sundberg, M., Persson, M., Kvassman, J.-O. & Månsson, A. (2007). "Effects of surface adsorption on catalytic activity of heavy meromyosin studied using fluorescent ATP analogue". Biochemistry, 24, 4917-4934
Open this publication in new window or tab >>"Effects of surface adsorption on catalytic activity of heavy meromyosin studied using fluorescent ATP analogue"
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2007 (English)In: Biochemistry, ISSN 0006-2960, E-ISSN 1520-4995, Vol. 24, p. 4917-4934Article in journal (Refereed) Published
National Category
Natural Sciences
Research subject
Natural Science, Biomedical Sciences
Identifiers
urn:nbn:se:lnu:diva-2360 (URN)
Available from: 2010-04-07 Created: 2010-04-07 Last updated: 2017-12-12Bibliographically approved
Sundberg, M., Bunk, R., Albet-Torres, N., Kvennefors, A., Persson, F., Montelius, L., . . . Månsson, A. (2006). Actin filament guidance on a chip: Toward high-throughput assays and lab-on-a-chip applications. Langmuir, 22(17), 7286-7295
Open this publication in new window or tab >>Actin filament guidance on a chip: Toward high-throughput assays and lab-on-a-chip applications
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2006 (English)In: Langmuir, Vol. 22, no 17, p. 7286-7295Article in journal (Refereed) Published
National Category
Natural Sciences
Research subject
Natural Science, Biomedical Sciences; Natural Science, Organic Chemistry; Biomedical Sciences, Pharmacology
Identifiers
urn:nbn:se:lnu:diva-690 (URN)
Available from: 2010-04-01 Created: 2010-04-01 Last updated: 2015-09-14Bibliographically approved
Sundberg, M., Balaz, M., Bunk, R., Rosengren-Holmberg, J., Montelius, L., Nicholls, I. A., . . . Månsson, A. (2006). Selective spatial localization of actomyosin motor function by chemical surface patterning. Langmuir, 22(17), 7302-7312
Open this publication in new window or tab >>Selective spatial localization of actomyosin motor function by chemical surface patterning
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2006 (English)In: Langmuir, Vol. 22, no 17, p. 7302-7312Article in journal (Refereed) Published
National Category
Natural Sciences
Research subject
Natural Science, Biomedical Sciences; Natural Science, Organic Chemistry; Biomedical Sciences, Pharmacology
Identifiers
urn:nbn:se:lnu:diva-689 (URN)
Available from: 2010-04-01 Created: 2010-04-01 Last updated: 2015-09-14Bibliographically approved
Månsson, A., Sundberg, M., Bunk, R., Balaz, M., Nicholls, I. A., Omling, P., . . . Montelius, L. (2005). Actin-based molecular motors for cargo transportation in nanotechnology - Potentials and challenges. IEEE transactions on advanced packaging, 28 (4), 547-555
Open this publication in new window or tab >>Actin-based molecular motors for cargo transportation in nanotechnology - Potentials and challenges
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2005 (English)In: IEEE transactions on advanced packaging, Vol. 28 (4), p. 547-555Article in journal (Refereed) Published
Research subject
Natural Science, Biomedical Sciences; Natural Science, Organic Chemistry; Biomedical Sciences, Pharmacology
Identifiers
urn:nbn:se:lnu:diva-686 (URN)
Available from: 2010-04-01 Created: 2010-04-01 Last updated: 2015-09-14Bibliographically approved
Bunk, R., Carlberg, P., Månsson, A., Nicholls, I. A., Omling, P., Sundberg, M., . . . Montelius, L. (2005). Guiding molecular motors with nano-imprinted structures. Japanese journal of applied physics. Part 1, Regular papers, short notes & review papers, 44 (5A), 3337-3340
Open this publication in new window or tab >>Guiding molecular motors with nano-imprinted structures
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2005 (English)In: Japanese journal of applied physics. Part 1, Regular papers, short notes & review papers, Vol. 44 (5A), p. 3337-3340Article in journal (Refereed) Published
Research subject
Natural Science, Biomedical Sciences; Natural Science, Organic Chemistry; Biomedical Sciences, Pharmacology
Identifiers
urn:nbn:se:lnu:diva-676 (URN)
Available from: 2010-04-01 Created: 2010-04-01 Last updated: 2015-09-14Bibliographically approved
Bunk, R., Sundberg, M., Månsson, A., Nicholls, I. A., Omling, P., Tågerud, S. & Montelius, L. (2005). Guiding motor-propelled molecules with nanoscale precision through silanized bi-channel structures. Nanotechnology, 16 (6), 710-717
Open this publication in new window or tab >>Guiding motor-propelled molecules with nanoscale precision through silanized bi-channel structures
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2005 (English)In: Nanotechnology, Vol. 16 (6), p. 710-717Article in journal (Refereed) Published
Research subject
Natural Science, Biomedical Sciences; Natural Science, Organic Chemistry; Biomedical Sciences, Pharmacology
Identifiers
urn:nbn:se:lnu:diva-677 (URN)
Available from: 2010-04-01 Created: 2010-04-01 Last updated: 2015-09-14Bibliographically approved
Bunk, R., Sundberg, M., Rosengren-Holmberg, J., Carlberg, P., Nicholls, I. A., Tågerud, S., . . . Montelius, L. (2004). A biomolecular nanoscale traffic system: Controlled motion of quantum dot labelled motor proteins. Venice, Italy, June 28 - July 2
Open this publication in new window or tab >>A biomolecular nanoscale traffic system: Controlled motion of quantum dot labelled motor proteins
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2004 (English)Other (Other academic)
Place, publisher, year, pages
Venice, Italy, June 28 - July 2: , 2004
Research subject
Natural Science, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-5159 (URN)
Note
Utgivare: NANO-8, Plats: Venice, Italy, June 28 - July 2, Sidor: [lecture]Available from: 2010-04-28 Created: 2010-04-28 Last updated: 2015-09-14Bibliographically approved
Montelius, L., Bunk, R., Sundberg, M., Rosengren-Holmberg, J., Carlberg, P., Nicholls, I. A., . . . Månsson, A. (2004). Fabrication and characterization of fully biocompatible nanostructured surfaces allowing functional studies of molecular motors. Gothenburg, Sweden, August 23-27
Open this publication in new window or tab >>Fabrication and characterization of fully biocompatible nanostructured surfaces allowing functional studies of molecular motors
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2004 (English)Other (Other academic)
Place, publisher, year, pages
Gothenburg, Sweden, August 23-27: , 2004
Research subject
Natural Science, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-5156 (URN)
Note
Utgivare: International Congress of Biological Physics, Plats: Gothenburg, Sweden, August 23-27 , Sidor: [invited lecture]Available from: 2010-04-28 Created: 2010-04-28 Last updated: 2015-09-14Bibliographically approved
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