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Andersson, Per-Ola
Publications (10 of 13) Show all publications
Karlsson, B. C. G., Rosengren, A. M., Andersson, P.-O. & Nicholls, I. A. (2009). Molecular Insights on the Two Fluorescence Lifetimes Displayed by Warfarin from Fluorescence Anisotropy and Molecular Dynamics Studies. Journal of Physical Chemistry B, 113(22), 7945-7949
Open this publication in new window or tab >>Molecular Insights on the Two Fluorescence Lifetimes Displayed by Warfarin from Fluorescence Anisotropy and Molecular Dynamics Studies
2009 (English)In: Journal of Physical Chemistry B, ISSN 1520-6106, E-ISSN 1520-5207, Vol. 113, no 22, p. 7945-7949Article in journal (Refereed) Published
Abstract [en]

A series of steady-state fluorescence anisotropy experiments has been performed to demonstrate the presence of a deprotonated open side chain form of warfarin in organic environments. We explain the observed emission-wavelength-dependent anisotropy of warfarin in ethanol, 2-propanol, and acetonitrile due to the coexistence of neutral isomers and deprotonated open side chain forms displaying different fluorescence decay kinetics. To investigate solvent-solute interactions in more detail, a series of molecular dynamics simulations was performed to study warfarin solvation and to predict the time scale of rotational diffusion displayed by this compound. Predictions obtained provide an explanation for the nonzero values in anisotropy observed for neutral isomers of warfarin associated with the short fluorescence lifetime (tau < 0.1 ns) and for an approximately zero anisotropy observed for the deprotonated open side chain form, which is associated with the longer fluorescence lifetime (tau = 0.5-1.6 ns). Finally, we address the potential use of fluorescence anisotropy for an increased understanding of the structural diversity of warfarin in protein binding pockets.

National Category
Organic Chemistry
Research subject
Chemistry, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-2108 (URN)10.1021/jp811242z (DOI)
Available from: 2010-04-06 Created: 2010-04-06 Last updated: 2018-11-16Bibliographically approved
Karlsson, B. C. G., Rosengren, A. M., Andersson, P.-O. & Nicholls, I. A. (2009). The spectrophysics of warfarin: Implications for protein binding. In: : . Paper presented at Affinity 2009. Reykjavik, Iceland, July 11-15
Open this publication in new window or tab >>The spectrophysics of warfarin: Implications for protein binding
2009 (English)Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
Reykjavik, Iceland, July 11-15: , 2009
Research subject
Natural Science, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-5054 (URN)
Conference
Affinity 2009
Note

Nummer:

Available from: 2010-04-28 Created: 2010-04-28 Last updated: 2016-11-11Bibliographically approved
Karlsson, B. C. G., Rosengren, A. M., Andersson, P.-O. & Nicholls, I. A. (2007). The Spectrophysics of Warfarin: Implications for Protein Binding. Journal of Physical Chemistry B, 111, 10520-10528
Open this publication in new window or tab >>The Spectrophysics of Warfarin: Implications for Protein Binding
2007 (English)In: Journal of Physical Chemistry B, ISSN 1520-6106, E-ISSN 1520-5207, Vol. 111, p. 10520-10528Article in journal (Refereed) Published
National Category
Natural Sciences
Research subject
Chemistry, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-2037 (URN)
Available from: 2010-04-06 Created: 2010-04-06 Last updated: 2018-11-16Bibliographically approved
Rosengren, A., Karlsson, J. G., Andersson, P.-O. & Nicholls, I. A. (2006). Chemometric models of synthetic receptor-ligand binding. In: . Paper presented at 20th Swedish Organic Chemistry Meeting. Kalmar, Sweden, June 12-15
Open this publication in new window or tab >>Chemometric models of synthetic receptor-ligand binding
2006 (English)Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
Kalmar, Sweden, June 12-15: , 2006
Research subject
Natural Science, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-5036 (URN)
Conference
20th Swedish Organic Chemistry Meeting
Note
Nummer: Available from: 2010-04-28 Created: 2010-04-28 Last updated: 2020-03-20Bibliographically approved
Rosengren, A., Karlsson, J. G., Andersson, P.-O. & Nicholls, I. A. (2006). Chemometric models of synthetic receptor-ligand binding. In: . Paper presented at Molecular Imprinting – 2006. Cardiff, Wales, September 10-14
Open this publication in new window or tab >>Chemometric models of synthetic receptor-ligand binding
2006 (English)Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
Cardiff, Wales, September 10-14: , 2006
Research subject
Natural Science, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-4984 (URN)
Conference
Molecular Imprinting – 2006
Note
Nummer: Available from: 2010-04-28 Created: 2010-04-28 Last updated: 2020-03-20Bibliographically approved
Karlsson, B., Rosengren, A., Andersson, P.-O. & Nicholls, I. A. (2006). The role of isomerization on the spectroscopic properties of Warfarin. In: . Paper presented at Molecular Imprinting – 2006. Cardiff, Wales, September 10-14
Open this publication in new window or tab >>The role of isomerization on the spectroscopic properties of Warfarin
2006 (English)Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
Cardiff, Wales, September 10-14: , 2006
Research subject
Natural Science, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-4983 (URN)
Conference
Molecular Imprinting – 2006
Note
Nummer: Available from: 2010-04-28 Created: 2010-04-28 Last updated: 2016-11-11Bibliographically approved
Karlsson, B., Rosengren, A., Andersson, P.-O. & Nicholls, I. A. (2006). The role of isomerization on the spectroscopic properties of Warfarin. In: . Paper presented at 20th Swedish Organic Chemistry Meeting. Kalmar, Sweden, June 12-15
Open this publication in new window or tab >>The role of isomerization on the spectroscopic properties of Warfarin
2006 (English)Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
Kalmar, Sweden, June 12-15: , 2006
Research subject
Natural Science, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-5026 (URN)
Conference
20th Swedish Organic Chemistry Meeting
Note
Nummer: Available from: 2010-04-28 Created: 2010-04-28 Last updated: 2016-11-11Bibliographically approved
Rosengren, A., Karlsson, J. G., Andersson, P.-O. & Nicholls, I. A. (2004). Chemometric study of binding to bupivacaine imprinted polymer. In: . Paper presented at Molecular Imprinting 2004. Cardiff, Wales, September 13-16
Open this publication in new window or tab >>Chemometric study of binding to bupivacaine imprinted polymer
2004 (English)Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
Cardiff, Wales, September 13-16: , 2004
Research subject
Natural Science, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-4995 (URN)
Conference
Molecular Imprinting 2004
Note
Nummer: Available from: 2010-04-28 Created: 2010-04-28 Last updated: 2020-03-20Bibliographically approved
Olofsson, L., Ankarloo, J., Andersson, P.-O. & Nicholls, I. A. (2003). Study of the molecular basis for filamentous bacteriophage stability in water-miscible organic solvents. In: . Paper presented at Annual Meeting of the Swedish Society for Biochemistry & Molecular Biology. Kalmar, Sweden, September 19-20
Open this publication in new window or tab >>Study of the molecular basis for filamentous bacteriophage stability in water-miscible organic solvents
2003 (English)Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
Kalmar, Sweden, September 19-20: , 2003
Research subject
Natural Science, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-5003 (URN)
Conference
Annual Meeting of the Swedish Society for Biochemistry & Molecular Biology
Note
Nummer: Available from: 2010-04-28 Created: 2010-04-28 Last updated: 2015-04-16Bibliographically approved
Olofsson, L., Ankarloo, J., Andersson, P.-O. & Nicholls, I. A. (2001). Bacteriophage viability in organic solvents. Chemistry & Biology, 8, 661-671
Open this publication in new window or tab >>Bacteriophage viability in organic solvents
2001 (English)In: Chemistry & Biology, Vol. 8, p. 661-671Article in journal (Refereed) Published
Research subject
Natural Science, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-892 (URN)
Available from: 2010-04-01 Created: 2010-04-01 Last updated: 2015-04-16Bibliographically approved
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