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Gustafsson, Katarina
Publications (7 of 7) Show all publications
Agger, R., Anderssen, V., Leslie, G., Aastedt, B. & Gustafsson, K. (2006). Immunologi. Svensk översättning från danska. Studentlitteratur
Open this publication in new window or tab >>Immunologi. Svensk översättning från danska
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2006 (Swedish)Book (Other academic)
Place, publisher, year, edition, pages
Studentlitteratur, 2006
National Category
Natural Sciences
Research subject
Natural Science, Biomedical Sciences
Identifiers
urn:nbn:se:lnu:diva-3186 (URN)
Note
Nummer: Available from: 2010-04-26 Created: 2010-04-26 Last updated: 2011-10-05Bibliographically approved
Sultana, T., Svechnikov, K. V., Gustafsson, K., Wahlgren, A., Tham, E., Weber, G. & Söder, O. (2004). Molecular identity, expression and functional analysis of interleukin-1alpha and its isoforms in rat testis.. Asian J Androl, 6, 149-153
Open this publication in new window or tab >>Molecular identity, expression and functional analysis of interleukin-1alpha and its isoforms in rat testis.
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2004 (English)In: Asian J Androl, Vol. 6, p. 149-153Article in journal (Refereed) Published
Research subject
Natural Science, Biomedical Sciences
Identifiers
urn:nbn:se:lnu:diva-2205 (URN)
Available from: 2010-04-07 Created: 2010-04-07 Last updated: 2011-09-29Bibliographically approved
Gustafsson, K., Sultana, T., Zetterström, C., Setchell, B., Siddiqui, A., Weber, G. & Söder, O. (2002). Production and secretion of interleukin-1 alpha proteins by rat testis.. Biochem Biophys Res Comm, 297, 492-497
Open this publication in new window or tab >>Production and secretion of interleukin-1 alpha proteins by rat testis.
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2002 (English)In: Biochem Biophys Res Comm, Vol. 297, p. 492-497Article in journal (Refereed) Published
Research subject
Natural Science, Biomedical Sciences
Identifiers
urn:nbn:se:lnu:diva-2206 (URN)
Available from: 2010-04-07 Created: 2010-04-07 Last updated: 2011-09-22Bibliographically approved
Wahab-Wahlgren, A., Holst, M., Ayele, D., Sultana, T., Parvinen, M., Gustafsson, K., . . . Söder, O. (2000). Constitutive production of interleukin-1 alpha mRNA and protein in the developing rat testis.. Int J Androl, 23, 360-365
Open this publication in new window or tab >>Constitutive production of interleukin-1 alpha mRNA and protein in the developing rat testis.
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2000 (English)In: Int J Androl, Vol. 23, p. 360-365Article in journal (Refereed) Published
Research subject
Natural Science, Biomedical Sciences
Identifiers
urn:nbn:se:lnu:diva-2207 (URN)
Available from: 2010-04-07 Created: 2010-04-07 Last updated: 2011-09-22Bibliographically approved
Gustafsson, K. (1998). Testicular interleukin-1 alpha: Isolation, purification and and identification of a constitutively produced and secreted cytokine by the intact adult rat testis. (Licentiate dissertation).
Open this publication in new window or tab >>Testicular interleukin-1 alpha: Isolation, purification and and identification of a constitutively produced and secreted cytokine by the intact adult rat testis
1998 (English)Licentiate thesis, monograph (Other academic)
Research subject
Natural Science, Biomedical Sciences
Identifiers
urn:nbn:se:lnu:diva-2987 (URN)
Presentation
(English)
Note
Nummer: Available from: 2007-06-26 Created: 2010-04-23 Last updated: 2010-04-23
Gustafsson, K., Söder, O., Pöllänen, P. & Ritzén, M. (1988). Isolation and partial characterization of an interleukin-1-like factor from rat testis interstitial fluid.. Journal of Reproductive Immunology, 14(2), 139-150
Open this publication in new window or tab >>Isolation and partial characterization of an interleukin-1-like factor from rat testis interstitial fluid.
1988 (English)In: Journal of Reproductive Immunology, ISSN 0165-0378, E-ISSN 1872-7603, Vol. 14, no 2, p. 139-150Article in journal (Refereed) Published
Abstract [en]

Testicular interstitial fluid (ISF) was collected by in vivo perfusion of rat testes and analyzed for the presence of interleukin-1 (IL-1) activity by utilizing a murine thymocyte proliferation assay. IS obtained from nine rats were all positive with dose-response curves of IL-1 activity similar to those produced by rat testicular aqueous extracts, rat macrophage IL-1 and human recombinant IL-1α. Chromatofocusing of pooled ISF revealed a single peak of IL-1 activity with an estimated isoelectric point of 6.1–6.3. HPLC size exclusion chromatography demonstrated two active peaks with apparent molecular ratios Mr of 15,000–18,000 and 5000–7000, respectively. The molecular properties of the 15,000–18,000 Mr component are very similar to those of an IL-1-like factor previously isolated from seminiferous tubules. Our results indicate that the testicular IL-1-like factor is secreted by the seminiferous tubules into the interstitial tissue. Its function in the testicular interstitium is unknown but it might be relevant for the tendency to testicular relapse of childhood lymphocytic leukemia. 

National Category
Medical and Health Sciences
Research subject
Natural Science, Biomedical Sciences
Identifiers
urn:nbn:se:lnu:diva-1819 (URN)10.1016/0165-0378(88)90065-4 (DOI)
Available from: 2010-04-06 Created: 2010-04-06 Last updated: 2017-12-12Bibliographically approved
Khan, S. A., Söder, O., Syed, V., Gustafsson, K., Lindh, M. & Ritzén, E. M. (1987). The rat testis produces large amounts of an interleukin-1 like factor.. International Journal of Andrology, 10(2), 495-503
Open this publication in new window or tab >>The rat testis produces large amounts of an interleukin-1 like factor.
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1987 (English)In: International Journal of Andrology, ISSN 0105-6263, E-ISSN 1365-2605, Vol. 10, no 2, p. 495-503Article in journal (Refereed) Published
Abstract [en]

Homogenates of whole testis, isolated seminiferous tubules, testicular cytosol, conditioned media from seminiferous tubules obtained from intact or cryptorchid rats, as well as seminiferous tubules devoid of peritubular cells, showed high concentrations of interleukin-1 (IL-1). Cytosol from spleen showed low IL-1 activity, while no activity was found in cytosol from heart, kidney, prostate, ovary or liver. Interleukin-1 activity was not detected in spent medium from cultures of immature Sertoli cells (10-day-old rats) or from peritubular cells or in homogenates of interstitial cells from adult rats. Ultrogel AcA 44 gel chromatography and HPLC size exclusion chromatography exhibited a single peak of IL-1 activity corresponding to a relative molecular mass of 17 000–20 000 (Mr= 17–20 K). Similarly, chromatofocusing revealed only one peak of activity with an apparent isoelectric point of 5–6. It is concluded that the rat testis contains large amounts of an IL-1α-like factor. The adult Sertoli cell or possibly germ cells are suggested as its primary source. Testicular IL-1-like activity is of particular interest in view of the intense cell proliferation during spermatogenesis, and the tendency to testicular relapse of acute lymphoblastic leukaemia. 

National Category
Medical and Health Sciences
Research subject
Natural Science, Biomedical Sciences
Identifiers
urn:nbn:se:lnu:diva-1818 (URN)10.1111/j.1365-2605.1987.tb00224.x (DOI)
Available from: 2010-04-06 Created: 2010-04-06 Last updated: 2017-12-12Bibliographically approved
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