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Coumarin-based molecular probes: exploring the spectroscopic properties of complex mixtures and applications in colloid chemistry
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
2018 (English)Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Warfarin is a well-known anticoagulant drug that is used to prevent cardiovascular disease and blood coagulation such as thrombosis. In this study, the main aim was to investigate the photo physical characteristics of warfarin in the different molecular environments provided by sodium dodecyl sulfate (SDS) micelles by using ultraviolet absorption and fluorescence emission spectroscopic techniques. Warfarin and a structural analogue not existing in solution as a cyclic hemiketal, phenprocoumon, were mixed with different concentrations of SDS and spectral changes for these warfarin and phenprocoumon were recorded. Interestingly, results demonstrated, based on an evident increase in the absorption intensity at 273 nm and an evident blue shift in the fluorescence emission spectrum after the addition of an increasing concentration of SDS, that primarily the cyclic hemiketal isomer of warfarin was found to be solvated by SDS micelles at an apparent recorded critical micelle concentration of ~8mM.  Altogether these observations suggest that warfarin may be used as a molecular probe to explore the polarities of complex colloidal mixtures. Moreover, the possibility of using micelles for controlling the isomeric state of warfarin is interesting and can potentially be used for better controlling dosage of warfarin thereby reducing side effects.

Place, publisher, year, edition, pages
2018. , p. 25
Series
Linnaeus University Dissertations
Keywords [en]
warfarin; phenprocoumon; fluorescence spectroscopy; ultraviolet absorption spectroscopy; sodium dodecyl sulfate; surfactant; micelles; critical micelle concentration.
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-79176OAI: oai:DiVA.org:lnu-79176DiVA, id: diva2:1270401
Subject / course
Chemistry
Educational program
Chemistry Master Programme, 60 credits
Supervisors
Examiners
Available from: 2018-12-19 Created: 2018-12-13 Last updated: 2018-12-19Bibliographically approved

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Department of Chemistry and Biomedical Sciences
Chemical Sciences

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
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Language
  • de-DE
  • en-GB
  • en-US
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  • Other locale
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Output format
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