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Alpha-nemertides - a novel family of nemertean peptide neurotoxins
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Uppsala university. (Linnaeus Ctr Biomat Chem, BMC)ORCID iD: 0000-0003-1241-8888
Uppsala University. (Department of Pharmacognosy)
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (BPL)
University of Queensland, Australia. (School of Biomedical Sciences)
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2018 (English)Conference paper, Oral presentation with published abstract (Other academic)
Abstract [en]

We recently discovered a novel family of neuroactive peptides in nemerteans, which we have named alpha-nemertides (1). One of these peptides, nemertide alpha-1, has been the subject of detailed studies with regard to structure and effects. The peptide exhibits exceptional potency against a number of arthropod species. Moreover, in vitro experiments suggest that alpha-1 acts primarily on voltage-gated sodium channels, and that this action is selective for arthropods by two orders of magnitude over vertebrate species. Using transcriptomic and proteomic approaches, we have identified 10 alpha-nemertides, but this number is likely to increase. These peptides alongside with a series of mutants are currently under evaluation by our group, with the goal to improve our understanding of structure-function relationships. In addition, we are considering potential practical uses of alpha-nemertides. In this talk, I will describe the current status of this research project.

1. E. Jacobsson et al., Peptide ion channel toxins from the bootlace worm, the longest animal on Earth. Scientific reports 8, 4596 (2018).

Place, publisher, year, edition, pages
2018. p. 2-
National Category
Biochemistry and Molecular Biology
Research subject
Chemistry, Medical Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-77432OAI: oai:DiVA.org:lnu-77432DiVA, id: diva2:1242644
Conference
9th International Conference on nemertean biology, List auf Sylt, Germany, August 13-17, 2018
Funder
Swedish Research Council, 214-3327Available from: 2018-08-28 Created: 2018-08-28 Last updated: 2019-02-22Bibliographically approved

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Andersson, Håkan S.Laborde, Quentin

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Andersson, Håkan S.Laborde, QuentinStrand, MalinGöransson, Ulf
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