lnu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Adjunctive galantamine, but not donepezil, enhances the antipsychotic-like effect of raclopride in rats.
Karolinska Institutet. (Torgny Svensson)
Karolinska Institutet. (Torgny Svensson)
Karolinska Institutet.
University of Kalmar, School of Pure and Applied Natural Sciences.ORCID iD: 0000-0003-1806-307X
Show others and affiliations
2008 (English)In: International Journal of Neuropsychopharmacology, ISSN 1461-1457, E-ISSN 1469-5111, Vol. 11, no 6, p. 845-850Article in journal (Refereed) Published
Abstract [en]

Acetylcholine (ACh) esterase inhibitors like galantamine and donepezil have been tested as adjunct treatment in schizophrenia. Although ACh esterase inhibition might confer some antipsychotic activity, the role of allosteric potentiation of nicotinic ACh receptors (nAChRs), which is an additional mechanism of galantamine, remains elusive. Therefore, the potential antipsychotic-like effects of galantamine and donepezil, respectively, alone, and in combination with the dopamine D2/3 receptor antagonist, raclopride, were tested in the conditioned avoidance response (CAR) test and extrapyramidal side-effect liability was assessed with the catalepsy test. Neither galantamine nor donepezil alone suppressed CAR selectively. Galantamine, but not donepezil, enhanced the raclopride-induced suppression of CAR, predicting augmentation of antipsychotic activity. In contrast to donepezil, galantamine did not increase catalepsy, alone or combined with raclopride. These data suggest that allosteric potentiation of nAChRs may mediate the antipsychotic-like effect of adjunctive galantamine and provide support for the development of α7 nAChR-selective allosteric potentiators for schizophrenia.

Place, publisher, year, edition, pages
Glasgow, UK: Cambridge Univ Press , 2008. Vol. 11, no 6, p. 845-850
Keywords [en]
Antipsychotics, experimental
National Category
Pharmacology and Toxicology
Research subject
Biomedical Sciences, Pharmacology
Identifiers
URN: urn:nbn:se:hik:diva-2961DOI: 10.1017/S1461145708008730ISI: 000259706800009OAI: oai:DiVA.org:hik-2961DiVA, id: diva2:302198
Available from: 2010-09-03 Created: 2010-03-04 Last updated: 2018-01-12Bibliographically approved

Open Access in DiVA

fulltext(76 kB)432 downloads
File information
File name FULLTEXT01.pdfFile size 76 kBChecksum SHA-512
17236ab351aadc53f35c93ec9d08d35cf57b155567c432e344c40aa25e27f0bdd9a708f2caa2d5b4e960c34bedcd5e8b6a37389c6a07ab72470137ca9788b285
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records BETA

Wadenberg, Marie-Louise

Search in DiVA

By author/editor
Wadenberg, Marie-Louise
By organisation
School of Pure and Applied Natural Sciences
In the same journal
International Journal of Neuropsychopharmacology
Pharmacology and Toxicology

Search outside of DiVA

GoogleGoogle Scholar
Total: 432 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 142 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf