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Coumarin-based molecular probes: exploring the spectroscopic properties of complex mixtures and applications in colloid chemistry
Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB).
2018 (engelsk)Independent thesis Advanced level (degree of Master (One Year)), 20 poäng / 30 hpOppgave
Abstract [en]

Warfarin is a well-known anticoagulant drug that is used to prevent cardiovascular disease and blood coagulation such as thrombosis. In this study, the main aim was to investigate the photo physical characteristics of warfarin in the different molecular environments provided by sodium dodecyl sulfate (SDS) micelles by using ultraviolet absorption and fluorescence emission spectroscopic techniques. Warfarin and a structural analogue not existing in solution as a cyclic hemiketal, phenprocoumon, were mixed with different concentrations of SDS and spectral changes for these warfarin and phenprocoumon were recorded. Interestingly, results demonstrated, based on an evident increase in the absorption intensity at 273 nm and an evident blue shift in the fluorescence emission spectrum after the addition of an increasing concentration of SDS, that primarily the cyclic hemiketal isomer of warfarin was found to be solvated by SDS micelles at an apparent recorded critical micelle concentration of ~8mM.  Altogether these observations suggest that warfarin may be used as a molecular probe to explore the polarities of complex colloidal mixtures. Moreover, the possibility of using micelles for controlling the isomeric state of warfarin is interesting and can potentially be used for better controlling dosage of warfarin thereby reducing side effects.

sted, utgiver, år, opplag, sider
2018. , s. 25
Serie
Linnaeus University Dissertations
Emneord [en]
warfarin; phenprocoumon; fluorescence spectroscopy; ultraviolet absorption spectroscopy; sodium dodecyl sulfate; surfactant; micelles; critical micelle concentration.
HSV kategori
Identifikatorer
URN: urn:nbn:se:lnu:diva-79176OAI: oai:DiVA.org:lnu-79176DiVA, id: diva2:1270401
Fag / kurs
Chemistry
Utdanningsprogram
Chemistry Master Programme, 60 credits
Veileder
Examiner
Tilgjengelig fra: 2018-12-19 Laget: 2018-12-13 Sist oppdatert: 2018-12-19bibliografisk kontrollert

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