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The link between morphology and complement in ocular disease
Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB). (Linnaeus Ctr Biomat Chem, BMC)ORCID-id: 0000-0002-9301-1977
Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB). (Linnaeus Ctr Biomat Chem, BMC)
Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB). Uppsala University, Sweden. (Linnaeus Ctr Biomat Chem, BMC)ORCID-id: 0000-0001-7888-1571
Uppsala University, Sweden.ORCID-id: 0000-0003-0057-2730
2017 (engelsk)Inngår i: Molecular Immunology, ISSN 0161-5890, E-ISSN 1872-9142, Vol. 89, s. 84-99Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

The complement system is a vital component of the immune-priveliged human eye that is always active at a low-grade level, preventing harmful intraocular injuries caused by accumulation of turnover products and controlling pathogens to preserve eye homeostasis and vision. The complement system is a double-edged sword that is essential for protection but may also become harmful and contribute to eye pathology. Here, we review the evidence for the involvement of complement system dysregulation in age-related macular degeneration, glaucoma, uveitis, and neuromyelitis optica, highlighting the relationship between morphogical changes and complement system protein expression and regulation in these diseases. The potential benefits of complement inhibition in age-related macular degeneration, glaucoma, uveitis, and neuromyelitis optica are abundant, as are those of further research to improve our understanding of complement-mediated injury in these diseases.

sted, utgiver, år, opplag, sider
Elsevier, 2017. Vol. 89, s. 84-99
Emneord [en]
Complement, Eye, Morphology, Age-related macular degeneration, Glaucoma, Uveitis, Neuromyelitis optica
HSV kategori
Forskningsprogram
Biomedicinsk vetenskap, Immunologi
Identifikatorer
URN: urn:nbn:se:lnu:diva-71382DOI: 10.1016/j.molimm.2017.05.028ISI: 000410014500010PubMedID: 28622910Scopus ID: 2-s2.0-85020678968OAI: oai:DiVA.org:lnu-71382DiVA, id: diva2:1187559
Konferanse
16th European Meeting on Complement in Human Disease (EMCHD), SEP 08-12, 2017, Copenhagen, DENMARK
Tilgjengelig fra: 2018-03-05 Laget: 2018-03-05 Sist oppdatert: 2020-06-05bibliografisk kontrollert

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Mohlin, CamillaSandholm, KerstinNilsson Ekdahl, Kristina

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