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Alpha-nemertides - a novel family of nemertean peptide neurotoxins
Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB). Uppsala university. (Linnaeus Ctr Biomat Chem, BMC)ORCID-id: 0000-0003-1241-8888
Uppsala University. (Department of Pharmacognosy)
Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB). (BPL)
University of Queensland, Australia. (School of Biomedical Sciences)
Vise andre og tillknytning
2018 (engelsk)Konferansepaper, Oral presentation with published abstract (Annet vitenskapelig)
Abstract [en]

We recently discovered a novel family of neuroactive peptides in nemerteans, which we have named alpha-nemertides (1). One of these peptides, nemertide alpha-1, has been the subject of detailed studies with regard to structure and effects. The peptide exhibits exceptional potency against a number of arthropod species. Moreover, in vitro experiments suggest that alpha-1 acts primarily on voltage-gated sodium channels, and that this action is selective for arthropods by two orders of magnitude over vertebrate species. Using transcriptomic and proteomic approaches, we have identified 10 alpha-nemertides, but this number is likely to increase. These peptides alongside with a series of mutants are currently under evaluation by our group, with the goal to improve our understanding of structure-function relationships. In addition, we are considering potential practical uses of alpha-nemertides. In this talk, I will describe the current status of this research project.

1. E. Jacobsson et al., Peptide ion channel toxins from the bootlace worm, the longest animal on Earth. Scientific reports 8, 4596 (2018).

sted, utgiver, år, opplag, sider
2018. s. 2-
HSV kategori
Forskningsprogram
Kemi, Medicinsk kemi
Identifikatorer
URN: urn:nbn:se:lnu:diva-77432OAI: oai:DiVA.org:lnu-77432DiVA, id: diva2:1242644
Konferanse
9th International Conference on nemertean biology, List auf Sylt, Germany, August 13-17, 2018
Forskningsfinansiär
Swedish Research Council, 214-3327Tilgjengelig fra: 2018-08-28 Laget: 2018-08-28 Sist oppdatert: 2019-02-22bibliografisk kontrollert

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Andersson, Håkan S.Laborde, Quentin

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