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Central Macular Thickness in Diabetic Patients: A Sex-based Analysis
Indiana University, USA.
Bowersox Vision Center, Shelbyville, USA.
Indiana University, USA.
Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för medicin och optometri (MEO). (REVO)ORCID-id: 0000-0002-3745-0035
Vise andre og tillknytning
2019 (engelsk)Inngår i: Optometry and Vision Science, ISSN 1040-5488, E-ISSN 1538-9235, Vol. 96, nr 4, s. 266-275Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

SIGNIFICANCE The pathological changes in clinically significant diabetic macular edema lead to greater retinal thickening in men than in women. Therefore, male sex should be considered a potential risk factor for identifying individuals with the most severe pathological changes. Understanding this excessive retinal thickening in men may help preserve vision. PURPOSE The purpose of this study was to investigate the sex differences in retinal thickness in diabetic patients. We tested whether men with clinically significant macular edema had even greater central macular thickness than expected from sex differences without significant pathological changes. This study also aimed to determine which retinal layers contribute to abnormal retinal thickness. METHODS From 2047 underserved adult diabetic patients from Alameda County, CA, 142 patients with clinically significant macular edema were identified by EyePACS-certified graders using color fundus images (Canon CR6-45NM). First, central macular thickness from spectral domain optical coherence tomography (iVue; Optovue Inc.) was compared in 21 men versus 21 women without clinically significant macular edema. Then, a planned comparison contrasted the greater values of central macular thickness in men versus women with clinically significant macular edema as compared with those without. Mean retinal thickness and variability of central macular layers were compared in men versus women. RESULTS Men without clinically significant macular edema had a 12-μm greater central macular thickness than did women (245 ± 21.3 and 233 ± 13.4 μm, respectively; t40 = −2.18, P = .04). Men with clinically significant macular edema had a 67-μm greater central macular thickness than did women (383 ± 48.7 and 316 ± 60.4 μm, P < .001); that is, men had 55 μm or more than five times more (t20 = 2.35, P = .02). In men, the outer-nuclear-layer thickness was more variable, F10,10 = 9.34. CONCLUSIONS Underserved diabetic men had thicker retinas than did women, exacerbated by clinically significant macular edema.

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American Academy of Optometry , 2019. Vol. 96, nr 4, s. 266-275
HSV kategori
Forskningsprogram
Naturvetenskap, Optometri
Identifikatorer
URN: urn:nbn:se:lnu:diva-81656DOI: 10.1097/OPX.0000000000001363ISI: 000463198100005PubMedID: 30907864Scopus ID: 2-s2.0-85063866010OAI: oai:DiVA.org:lnu-81656DiVA, id: diva2:1302210
Tilgjengelig fra: 2019-04-03 Laget: 2019-04-03 Sist oppdatert: 2019-08-29bibliografisk kontrollert

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