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Expression of the endogenous, nicotinic acetylcholine receptor ligand, SLURP-1, in human colon cancer.
Högskolan i Kalmar, Naturvetenskapliga institutionen.
Vise andre og tillknytning
2008 (engelsk)Inngår i: Autonomic & Autacoid Pharmacology, ISSN 1474-8665, E-ISSN 1474-8673, Vol. 28, nr 4, s. 109-116Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

1. Secreted mammalian Ly-6/urokinase plasminogen activator receptor-related protein-1 (SLURP-1) is a recently discovered endogenous ligand at the alpha7 subunit of the nicotinic acetylcholine receptors. Previous reports have shown that SLURP-1 is expressed in normal human keratinocytes seemingly with a pro-apoptotic function. Conversely, such expression was markedly attenuated in transformed cells and it was suggested that the molecule could convey protection against malignant transformation. 2. In this study, we demonstrated the mRNA expression (by RT-PCR) and protein expression (by Western blotting and immunocytochemistry) of SLURP-1 in the human colon cancer cell line, HT-29. 3. Furthermore, we demonstrated the expression of SLURP-1 (by immunohistochemistry) in tumour cells of human colon cancer tissue, and, to a greater extent, in immune and smooth muscle cells of adjacent, macroscopically tumour-free colon tissue. 4. The current findings suggest that SLURP-1 participates in the regulation of gut immune functions and motility, as well as possibly playing a role in colon carcinogenesis/cancer progression.

sted, utgiver, år, opplag, sider
2008. Vol. 28, nr 4, s. 109-116
HSV kategori
Forskningsprogram
Naturvetenskap, Biomedicinsk vetenskap
Identifikatorer
URN: urn:nbn:se:hik:diva-2322DOI: 10.1111/j.1474-8673.2008.00424.xOAI: oai:DiVA.org:hik-2322DiVA, id: diva2:274889
Tilgjengelig fra: 2009-11-03 Laget: 2009-11-02 Sist oppdatert: 2017-12-12bibliografisk kontrollert
Inngår i avhandling
1. Aspects of Non-Neuronal Signalling Functions of Acetylcholine in Colorectal Cancer: Roles for the α7nAChR
Åpne denne publikasjonen i ny fane eller vindu >>Aspects of Non-Neuronal Signalling Functions of Acetylcholine in Colorectal Cancer: Roles for the α7nAChR
2009 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
sted, utgiver, år, opplag, sider
Kalmar: Högskolan i Kalmar, 2009. s. 60
Serie
Dissertation series / University of Kalmar, Faculty of Natural Science, ISSN 1650-2779 ; 76
Emneord
alpha7 nicotinic acetylcholine receptor, acetylcholine, colorectal cancer, morphine, nicotine, plasminogen activator inhibitor-1, SLURP-1
HSV kategori
Forskningsprogram
Naturvetenskap, Biomedicinsk vetenskap
Identifikatorer
urn:nbn:se:hik:diva-2348 (URN)978-91-85993-37-6 (ISBN)
Disputas
2009-09-25, Falkens hörsal (C305), Nygatan 18B, Kalmar, 09:00 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2009-11-04 Laget: 2009-11-04 Sist oppdatert: 2016-03-11bibliografisk kontrollert

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