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Warfarin: an environment-dependent switchable molecular probe
Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV. (BBCL)ORCID-id: 0000-0002-0407-6542
Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV. (PPL ; BMC)ORCID-id: 0000-0002-7392-0591
Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV. (BBCL)
Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV. (BBCL)
2010 (engelsk)Inngår i: Journal of Molecular Recognition, ISSN 0952-3499, E-ISSN 1099-1352, Vol. 23, nr 6, s. 604-608Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The complex nature of the structure of the anticoagulant warfarin is reflected in the diversity of binding modes observed in warfarin–protein recognition systems. A series of theoretical, 1H-NMR and steady state and time resolved fluorescence spectroscopic studies, have been used to establish correlations between the molecular environment provided by various solvent systems and the relative concentrations of the various members of warfarin's ensemble of isomers. A consequence of these observations is that the judicious choice of solvent system or molecular environment of warfarin allows for manipulation of the position of the equilibrium between isomeric structures such as the hemiacetal and open phenol-keto forms, the latter even possible in a deprotonated form, where in each case unique spectroscopic properties are exhibited by the respective structures. Collectively, warfarin's capacity to adapt its structure as a function of environment in conjunction with the fluorescence behaviours of the various isomers together provide an environment-dependent molecular switch with reporter properties, which allows for the simultaneous detection of warfarin in different states with lifetimes spanning the range < 0.10–5.5 ns. These characteristics are here used to examine warfarin binding domains in a series of materials (solvents, protein, inorganic matrix and synthetic polymer). Moreover, these studies demonstrate the potential for using warfarin, or other switchable analogues thereof, as a tool for studying molecular level characteristics, for example local dielectricity. Copyright © 2010 John Wiley & Sons, Ltd.

sted, utgiver, år, opplag, sider
2010. Vol. 23, nr 6, s. 604-608
Emneord [en]
warfarin, fluorescence, fluorescence lifetimes, organic solvents, molecular recognition, molecular probe, molecularly imprinted polymer, human serum albumin;HSA, colloidal silica, TCSPC
HSV kategori
Forskningsprogram
Naturvetenskap, Biomedicinsk vetenskap
Identifikatorer
URN: urn:nbn:se:lnu:diva-7954DOI: 10.1002/jmr.1058PubMedID: 21031478Scopus ID: 2-s2.0-77956717111OAI: oai:DiVA.org:lnu-7954DiVA, id: diva2:346254
Tilgjengelig fra: 2010-08-31 Laget: 2010-08-31 Sist oppdatert: 2017-12-12bibliografisk kontrollert

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