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Temporary rise of blood pressure at start of insulin treatment in type II Diabetics
Department of Clinical Physiology, Central Hospital, Växjö, Sweden.
2002 (engelsk)Inngår i: 49th Annual World Assembly of the American College of Angiology, Maui, USA, October 13-18, 2002., 2002Konferansepaper, Publicerat paper (Fagfellevurdert)
Abstract [en]

Abstract

As a substudy of a broader investigation, concerning hemorheological effects of insulin treatment in insufficiently controlled type 2 diabetics, blood pressure was recorded in twelve patients before, after two months and after four months on insulin. After two months on insulin analyses of  MCV, S-Na, S-GT, total cholesterol, HDL-cholesterol and triglycerides indicated metabolic improvement (p<0.05-0.00 1). Besides a surprisingly uniform increase of both systolic and diastolic blood pressure (p<0.05) was found. No significant changes of the flow behaviour of blood were seen. After four months on insulin blood pressure had returned to pre-treatment values (p<0.05-0.01) or even lower. Further metabolic improvement (p<0.05-0.001) but no significant hemorheological improvement was now seen. Our number of patients was rather small and the study was not primarily designed for studies on blood pressure. Our preliminary conclusion from this study, however, has to be that institution of insulin treatment in poorly controlled type I1 diabetics causes a temporary and possibly clinically significant elevation of blood pressure. Further studies seem to be warranted to confirm our findings. Earlier studies have shown that insulin treatment may cause an increased albumin escape rate, increased plasma volume and systemic ("insulin-") oedema. A changed renal handling of sodium caused by insulin, might be one of several possible explanations to our results.

sted, utgiver, år, opplag, sider
2002.
Emneord [en]
Insulin treatment; Type 2 diabetics; Blood pressure; Sodium; Systemic oedema
HSV kategori
Forskningsprogram
Naturvetenskap, Biomedicinsk vetenskap; Hälsovetenskap, Vårdvetenskap
Identifikatorer
URN: urn:nbn:se:lnu:diva-11769OAI: oai:DiVA.org:lnu-11769DiVA, id: diva2:417985
Konferanse
49th Annual World Assembly of the American College of Angiology, Maui, USA, October 13-18, 2002.
Tilgjengelig fra: 2011-05-19 Laget: 2011-05-19 Sist oppdatert: 2011-09-29bibliografisk kontrollert

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