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Death of photoreceptors in organotypic retinal explant cultures: implication of rhodopsin accumulation and endoplasmic reticulum stress.
Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV. (Retinal research)
Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV.
2011 (engelsk)Inngår i: Journal of Neuroscience Methods, ISSN 0165-0270, E-ISSN 1872-678X, ISSN 0165-0270, Vol. 197, nr 1, s. 56-64Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Here we suggest that endoplasmic reticulum (ER)-stress may be induced following aberrant rhodopsin accumulation in photoreceptors in explanted rat retinas. Rhodopsin accumulation was accompanied by increased phosphorylation of pancreatic ER-kinase and eukaryotic initiator factor 2α as well as increased levels of C/EBP homologous protein, glucose-regulated protein 78 and eventually increased cleaved caspase-12 and cleaved caspase-3. Glucose-regulated protein 78, pancreatic ER-kinase, caspase-12 and cleaved caspase-3 were present in photoreceptors, indicating that ER-stress and apoptosis are induced in this cell population. These results suggest that ER-stress and subsequent apoptosis is induced in healthy photoreceptors, presumably by aberrant accumulation of rhodopsin and the phosphorylation of eukaryotic initiator factor 2α. The explant culture system may allow investigations of neuroprotective strategies.

sted, utgiver, år, opplag, sider
2011. Vol. 197, nr 1, s. 56-64
Emneord [en]
Retina, Photoreceptor, Apoptosis, ER stress, Rhodopsin
HSV kategori
Forskningsprogram
Naturvetenskap, Biomedicinsk vetenskap
Identifikatorer
URN: urn:nbn:se:lnu:diva-23046DOI: 10.1016/j.jneumeth.2011.01.030Scopus ID: 2-s2.0-79953054741OAI: oai:DiVA.org:lnu-23046DiVA, id: diva2:579080
Tilgjengelig fra: 2012-12-19 Laget: 2012-12-19 Sist oppdatert: 2017-12-06bibliografisk kontrollert
Inngår i avhandling
1. Neural progenitor cell-derived neurotrophic support for the degenerating retina: an in vitro study
Åpne denne publikasjonen i ny fane eller vindu >>Neural progenitor cell-derived neurotrophic support for the degenerating retina: an in vitro study
2013 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
sted, utgiver, år, opplag, sider
Växjö: Linnaeus University press, 2013. s. 77
Serie
Linnaeus University Dissertations ; 158
Emneord
retinal degeneration, apoptosis, retina, ER-stress, autophagy
HSV kategori
Forskningsprogram
Naturvetenskap, Biomedicinsk vetenskap
Identifikatorer
urn:nbn:se:lnu:diva-31164 (URN)978-91-87427-67-1 (ISBN)
Disputas
2013-12-20, N2007, Västergård, Kalmar, 09:00 (svensk)
Opponent
Veileder
Tilgjengelig fra: 2014-02-03 Laget: 2013-12-10 Sist oppdatert: 2014-02-03bibliografisk kontrollert

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