Model-based approaches and related industrial applications were used in industrial case-studies in the railway and metropolitan transport sectors. Each of the presented an application of advanced modeling techniques to problems related to safety, reliability, and security. These experiences highlighted an efficient transfer to the industry of tools and methods developed in the academy. A method was described for the availability evaluation of a railway system considering all the failure modes and fault origins and exploiting a modeling technique known as 'multi-formalism'. A safety evaluation technique was demonstrated for majority voting systems in presence of imperfect maintenance, using abstraction and modeling techniques based on different languages. The concept of model-based-testing was also introduced to improve effectiveness and efficiency of the certification process.