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Complement Diagnostics: Concepts, Indications, and Practical Guidelines
Uppsala University.
Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV. Uppsala University.ORCID-id: 0000-0001-7888-1571
2012 (Engelska)Ingår i: Clinical & Developmental Immunology, ISSN 1740-2522, E-ISSN 1740-2530, artikel-id 962702Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Aberrations in the complement system have been shown to be direct or indirect pathophysiological mechanisms in a number of diseases and pathological conditions such as autoimmune disease, infections, cancer, allogeneic and xenogeneic transplantation, and inflammation. Complement analyses have been performed on these conditions in both prospective and retrospective studies and significant differences have been found between groups of patients, but in many diseases, it has not been possible to make predictions for individual patients because of the lack of sensitivity and specificity of many of the assays used. The basic indications for serological diagnostic complement analysis today may be divided into three major categories: (a) acquired and inherited complement deficiencies; (b) disorders with complement activation; (c) inherited and acquired C1INH deficiencies. Here, we summarize indications, techniques, and interpretations for basic complement analyses and present an algorithm, which we follow in our routine laboratory.

Ort, förlag, år, upplaga, sidor
2012. artikel-id 962702
Nationell ämneskategori
Immunologi
Forskningsämne
Biomedicinsk vetenskap, Immunologi
Identifikatorer
URN: urn:nbn:se:lnu:diva-23367DOI: 10.1155/2012/962702ISI: 000311576600001Scopus ID: 2-s2.0-84871389256OAI: oai:DiVA.org:lnu-23367DiVA, id: diva2:584673
Tillgänglig från: 2013-01-09 Skapad: 2013-01-09 Senast uppdaterad: 2017-12-06Bibliografiskt granskad

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Nilsson Ekdahl, Kristina

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