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Fixation in Patients with Juvenile Macular Disease
University of Minho, Portugal.ORCID iD: 0000-0003-3436-2010
University of Minho, Portugal.
University of Porto, Portugal.
University of Porto, Portugal.
2007 (English)In: Optometry and Vision Science, ISSN 1040-5488, E-ISSN 1538-9235, Vol. 84, no 9, p. 852-858Article in journal (Refereed) Published
Abstract [en]

Purpose. The instability of fixation with central scotoma has been mainly studied in patients with age-related macular diseases (MDs). However, early macular lesions can lead to different characteristics of fixation. The aim of this work was to study fixation in patients with juvenile MD.

Methods. Eye movements of 10 patients and 10 controls were monitored during fixation. Visual fields were assessed by static perimetry to determine the extent of the field defects. Eye movements were separated into saccades and drifts, with fixation stability assessed by bivariate contour ellipse area (BCEA). To quantify the number and location of preferred retinal loci (PRL), the kernel density estimator and expectation maximization for mixtures of gaussians were used.

Results. Patients have worse fixation stability than controls and large BCEAs resulted in more than one PRL. It was found that central field defects (10°) have negative correlation with the size of BCEA. In addition, the meridian of saccades during fixation was correlated with the meridian inter-PRL.

Conclusions. Patients with juvenile MDs have large BCEAs, frequently associated with two PRL. Similar results had been found for patients with age-related MDs. Also, the meridian of involuntary saccades during fixation was found to be correlated with the location of PRLs, suggesting a useful role of these movements in alternating between them.

Place, publisher, year, edition, pages
2007. Vol. 84, no 9, p. 852-858
Keywords [en]
fixation stability, preferred retinal locus, eccentric fixation, eye movements
National Category
Ophthalmology
Research subject
Natural Science, Optometry
Identifiers
URN: urn:nbn:se:lnu:diva-68118DOI: 10.1097/OPX.0b013e3181559bebOAI: oai:DiVA.org:lnu-68118DiVA, id: diva2:1145300
Available from: 2017-09-28 Created: 2017-09-28 Last updated: 2017-09-29Bibliographically approved

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Macedo, António Filipe

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