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Dispersion of TiO2 nanoparticles improves burn wound healing and tissue regeneration through specific interaction with blood serum proteins
Swedish University of Agricultural Sciences.
Uppsala University.
ITMO Univ Kronverksky, Russia.
Ivanovo State Med Acad, Russia.
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2017 (Engelska)Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, artikel-id 15448Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Burn wounds are one of the most important causes of mortality and especially morbidity around the world. Burn wound healing and skin tissue regeneration remain thus one of the most important challenges facing the mankind. In the present study we have addressed this challenge, applying a solution-stabilized dispersion TiO2 nanoparticles, hypothesizing that their ability to adsorb proteins will render them a strong capacity in inducing body fluid coagulation and create a protective hybrid material coating. The in vitro study of interaction between human blood and titania resulted at enhanced TiO2 concentrations in formation of rather dense gel composite materials and even at lower content revealed specific adsorption pattern initiating the cascade response, promising to facilitate the regrowth of the skin. The subsequent in vivo study of the healing of burn wounds in rats demonstrated formation of a strongly adherent crust of a nanocomposite, preventing infection and inflammation with quicker reduction of wound area compared to untreated control. The most important result in applying the TiO2 dispersion was the apparently improved regeneration of damaged tissues with appreciable decrease in scar formation and skin color anomalies.

Ort, förlag, år, upplaga, sidor
Nature Publishing Group, 2017. Vol. 7, artikel-id 15448
Nationell ämneskategori
Biokemi och molekylärbiologi
Forskningsämne
Kemi, Biokemi
Identifikatorer
URN: urn:nbn:se:lnu:diva-69685DOI: 10.1038/s41598-017-15792-wISI: 000415023200009PubMedID: 29133853Scopus ID: 2-s2.0-85034086071OAI: oai:DiVA.org:lnu-69685DiVA, id: diva2:1172695
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Correction published in: Scientific Reports, vol 8, article id 4416, DOI: 10.1038/s41598-018-22717-8

Tillgänglig från: 2018-01-10 Skapad: 2018-01-10 Senast uppdaterad: 2019-08-29Bibliografiskt granskad

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Nilsson Ekdahl, Kristina

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