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Peptide ion channel toxins from the bootlace worm, the longest animal on Earth
Uppsala University, Sweden.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (Linnaeus Ctr Biomat Chem, BMC)ORCID iD: 0000-0003-1241-8888
Swedish University of Agricultural Sciences, Sweden.
Univ Leuven, Belgium.
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 4596Article in journal (Refereed) Published
Abstract [en]

Polypeptides from animal venoms have found important uses as drugs, pharmacological tools, and within biotechnological and agricultural applications. We here report a novel family of cystine knot peptides from nemertean worms, with potent activity on voltage-gated sodium channels. These toxins, named the alpha-nemertides, were discovered in the epidermal mucus of Lineus longissimus, the 'bootlace worm' known as the longest animal on earth. The most abundant peptide, the 31-residue long alpha-1, was isolated, synthesized, and its 3D NMR structure determined. Transcriptome analysis including 17 species revealed eight alpha-nemertides, mainly distributed in the genus Lineus. alpha-1 caused paralysis and death in green crabs (Carcinus maenas) at 1 mu g/kg (similar to 300 pmol/kg). It showed profound effect on invertebrate voltage-gated sodium channels (e.g. Blattella germanica Na(v)1) at low nanomolar concentrations. Strong selectivity for insect over human sodium channels indicates that a-nemertides can be promising candidates for development of bioinsecticidal agents.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018. Vol. 8, article id 4596
Keywords [en]
ribbon worms, nemertea, peptide toxin, sodium channel, insecticide
National Category
Biochemistry and Molecular Biology
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-72295DOI: 10.1038/s41598-018-22305-wISI: 000428029600001PubMedID: 29567943Scopus ID: 2-s2.0-85044358780OAI: oai:DiVA.org:lnu-72295DiVA, id: diva2:1195728
Funder
Swedish Research Council, 2014-3327Available from: 2018-04-06 Created: 2018-04-06 Last updated: 2019-08-29Bibliographically approved

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Andersson, Håkan S.Rosengren, K. Johan

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