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Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction
Oslo Univ Hosp, Norway;Univ Oslo, Norway.
Univ Oslo, Norway;Oslo Univ Hosp Ulleval, Norway.
Univ Oslo, Norway.;Oslo Univ Hosp, Norway;Univ Tromso, Norway.
Oslo Univ Hosp Ulleval, Norway;Feiring Heart Clin, Norway.
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2018 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 268, p. 187-192Article in journal (Refereed) Published
Abstract [en]

Background: The inflammatory response following myocardial infarction (MI) is prerequisite for proper healing of infarcted tissue, but can also have detrimental effects on cardiac function. Interleukin (IL)-1 alpha and IL-1 beta are potent inflammatory mediators and their bioactivity is tightly regulated by IL-1 receptor antagonist (IL-1ra) and soluble (s) IL-1 receptors (R). We aimed to examine whether levels of soluble regulators of IL-1 signalling are changed during ST-elevation MI (STEMI) and their associations with parameters of cardiac injury and ventricular remodelling. Methods: Plasma levels of IL-1Ra, sIL-1R1, sIL-1R2 and sIL-1R accessory protein (sIL-1RAcP) were measured by immunoassays in repeated samples from patients with STEMI (n = 255) and compared to healthy controls (n=65). Results: IL-1Ra, sIL-1R1 and sIL-1R2 levels were all significantly elevated after STEMI, while levels of sIL-1RAcP were lower compared to controls. sIL-1R2 levels (at different time points) correlated positively with C-reactive protein, myocardial infarct size and change in indexed left ventricular end-diastolic and end-systolic volume (LVEDVi and LVESVi) measured by cardiac MR acutely and after 4 months, and negatively with LV ejection fraction. Patients with >median levels of sIL-1R2 in the acute phase were more likely to have increased change in LVEDVi and LVESVi. Importantly, sIL-1R2 remained significantly associated with change in LVEDVi and LVESVi also after adjustment for clinical covariates. Conclusion: Levels of sIL-1R2 are independently associated with parameters of LV adverse remodelling following STEMI. (C 18 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 268, p. 187-192
Keywords [en]
Inflammation, Cytokine, Interleukin-1, Acute coronary syndromes, Myocardial infarction, Ventricular remodelling
National Category
Biochemistry and Molecular Biology
Research subject
Natural Science, Biomedical Sciences; Chemistry, Biochemistry
Identifiers
URN: urn:nbn:se:lnu:diva-77369DOI: 10.1016/j.ijcard.2018.05.032ISI: 000439363400045PubMedID: 29853279OAI: oai:DiVA.org:lnu-77369DiVA, id: diva2:1243305
Available from: 2018-08-30 Created: 2018-08-30 Last updated: 2018-11-16Bibliographically approved

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Nilsson, Per H.

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