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Relationships between neuropsychological and antisaccade measures in multiple sclerosis patients
University of Minho, Portugal;Association “Todos com a Esclerose Multipla (TEM)”, Portugal.
Association “Todos com a Esclerose Multipla (TEM)”, Portugal;University of Minho, Portugal.
Association “Todos com a Esclerose Multipla (TEM)”, Portugal.
University of Minho, Portugal.
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2018 (English)In: PeerJ, ISSN 2167-8359, E-ISSN 2167-8359, Vol. 6, p. 1-18, article id e5737Article in journal (Refereed) Published
Abstract [en]

Background

The Stroop test is frequently used to assess deficits in inhibitory control in people with multiple sclerosis (MS). This test has limitations and antisaccade eye movements, that also measure inhibitory control, may be an alternative to Stroop.

Objectives

The aim of this study was twofold: (i) to investigate if the performance in the antisaccade task is altered in patients with MS and (ii) to investigate the correlation between performances in neuropsychological tests, the Stroop test and the antisaccade task.

Methods

We measured antisaccades (AS) parameters with an infrared eye tracker (SMIRED 250 Hz) using a standard AS paradigm. A total of 38 subjects diagnosed with MS and 38 age and gender matched controls participated in this study. Neuropsychological measures were obtained from the MS group.

Results

Patients with MS have higher error rates and prolonged latency than controls in the antisaccade task. There was a consistent association between the Stroop performance and AS latency. Stroop performance but not AS latency was associated with other neuropsychological measures in which the MS group showed deficits.

Conclusions

Our findings suggest that AS may be a selective and independent measure to investigate inhibitory control in patients with MS. More studies are necessary to confirm our results and to describe brain correlates associated with impaired performance in the antisaccade task in people diagnosed with MS.

Place, publisher, year, edition, pages
PeerJ, Inc , 2018. Vol. 6, p. 1-18, article id e5737
Keywords [en]
Eye movements, Antisaccades, Multiple sclerosis, Stroop test, Inhibitory control, Executive functions
National Category
Neurosciences Neurology Ophthalmology
Research subject
Natural Science, Optometry; Natural Science, Medicine
Identifiers
URN: urn:nbn:se:lnu:diva-78179DOI: 10.7717/peerj.5737ISI: 000447207100008PubMedID: 30310755Scopus ID: 2-s2.0-85054807469OAI: oai:DiVA.org:lnu-78179DiVA, id: diva2:1253466
Available from: 2018-10-04 Created: 2018-10-04 Last updated: 2019-08-29Bibliographically approved

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Macedo, António Filipe

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