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Two-peaked increase of serum myosin heavy chain-α after triathlon suggests heart muscle cell death
Linnaeus University, Faculty of Social Sciences, Department of Sport Science. (Iron(wo)man)ORCID iD: 0000-0002-1626-4575
Kalmar County Hospital, Sweden.
Kalmar County Hospital, Sweden.ORCID iD: 0000-0002-1707-2655
Kalmar County Hospital, Sweden.
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2019 (English)In: BMJ Open Sport & Exercise Medicine, ISSN 2055-7647, Vol. 5, article id e000486Article in journal (Refereed) Published
Abstract [en]

Objective It has been suggested that the mechanism behind cardiac troponin elevation after strenuous exercise is passage through a cell membrane with changed permeability rather than myocardial cell death. We hypothesised that an increase of cardiac specific myosin heavy chain-alpha (MHC-α; 224 kDa compared with cardiac troponin T’s (cTnT) 37 kDa) could hardly be explained by passage through a cell membrane.

Methods Blood samples were collected from 56 athletes (15 female, age 42.5±9.7, range 24–70 years) before, directly after and on days 1–8 after an Ironman. Biomarkers (C reactive protein (CRP), cTnT, creatinekinase (CK), MHC-α, myoglobin (MG), creatinine (C) and N-terminal prohormone of brain natriuretic peptide (NTproBNP) were measured.

Results The course of MHC-α concentration (μg/L) was 1.33±0.53 (before), 2.57±0.78 (directly after), 1.51±0.53 (day 1), 2.74±0.55 (day 4) and 1.83±0.76 (day 6). Other biomarkers showed a one-peaked increase with maximal values either directly after the race or at day 1: cTnT 76 ±80 ng/L (12–440; reference<15), NT-proBNP 776±684 ng/L (92–4700; ref.<300), CK 68±55 μkat/L (5–280; ref.<1.9), MG 2088±2350 μg/L (130–17 000; ref.<72) and creatinine 100±20 μmol/L (74–161; ref.<100), CRP 49±23 mg/L(15–119; ref.<5).

Conclusion MHC-α exhibited a two-peaked increase which could represent a first release from the cytosolic pool and later from cell necrosis. This is the first investigation of MHC-α plasma concentration afterexercise.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2019. Vol. 5, article id e000486
Keywords [en]
cardiovascular medicine, physiology, sports and exercise medicine
National Category
Sport and Fitness Sciences Cardiac and Cardiovascular Systems
Research subject
Social Sciences, Sport Science
Identifiers
URN: urn:nbn:se:lnu:diva-79922DOI: 10.1136/ bmjsem-2018-000486PubMedID: 30740234Scopus ID: 2-s2.0-85060492223OAI: oai:DiVA.org:lnu-79922DiVA, id: diva2:1282639
Available from: 2019-01-25 Created: 2019-01-25 Last updated: 2019-05-23Bibliographically approved

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Danielsson, TomWoksepp, HannaBergman, PatrickMånsson, AlfCarlsson, Jörg

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Sport and Fitness SciencesCardiac and Cardiovascular Systems

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