The study was performed to examine and assess the impact of the education, occupation and leisure time on building brain and cognitive reserves (CBR). A cross sectional study of 132 persons at age between 40 to 70 years old has been conducted. A structuredquestionnaire covering multiple constructs was used to collect the data. Multivariate regression results show that the three independent variables (LE, OC and ED) were statistically significant in the models with CBR as dependent variable. Leisure time and activities (LE) makethe strongest unique contribution (0.683) followed by occupation (0.261) and the weak contribution of the education (0.198) to explainthe dependent variable cognitive and brain reserve (CBR).The Brain and Cognitive Reserve hypothesesassumes that a rich intellectual measures and abilities a person have during her/his life enable this person to copewith difficult cognitive tasks and social events in life.