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Impact of Menstrual Function on Hormonal Response to Repeated Bouts of Intense Exercise
Linnaeus University, Faculty of Social Sciences, Department of Sport Science. Univ Copenhagen, Denmark.ORCID iD: 0000-0002-8249-1311
Univ Copenhagen, Denmark.
Univ Copenhagen, Denmark;Herlev Hosp, Denmark.
Univ Copenhagen, Denmark;Herlev Hosp, Denmark.
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2019 (English)In: Frontiers in Physiology, ISSN 1664-042X, E-ISSN 1664-042X, Vol. 10, p. 1-8, article id 942Article in journal (Refereed) Published
Abstract [en]

Background: Strenous exercise stimulates the hypothalamic-pituitary (HP) axis in order to ensure homeostasis and promote anabolism. Furthermore, exercise stimulates a transient increase in the neurotrophin brain-derived neurotrophic factor (BDNF) suggested to mediate the anxiolytic effects of exercise. Athletes with secondary functional hypothalamic amenorrhea (FHA) have been reported to have lower BDNF, and a blunted HP axis response to exercise as athletes with overtraining syndrome. Aim: The aim of the study was to investigate the hormonal and BDNF responses to a two-bout maximal exercise protocol with four hours of recovery in between in FHA and eumenorrheic (EUM) athletes. Methods: Eumenorrheic (n = 16) and FHA (n = 14) endurance athletes were recruited from national teams and competitive clubs. Protocols included gynecological examination; body composition (DXA); 7-day assessment of energy availability; blood sampling pre and post the two exercises tests. Results: There were no differences between groups in hormonal responses to the first exercise bout. After the second exercise bout IGFBP-3 increased more in FHA compared with EUM athletes (2.1 +/- 0.5 vs. 0.6 +/- 0.6 mu g/L, p = 0.048). There were non-significant trends toward higher increase in IGF-1 (39.3 +/- 4.3 vs. 28.0 +/- 4.6 mu g/L, p = 0.074), BDNF (96.5 +/- 22.9 vs. 34.4 +/- 23.5 mu g/L, p = 0.058), GH to cortisol ratio (0.329 +/- 0.010 vs. 0.058 +/- 0.010, p = 0.082), and decrease in IGF-1 to IGFBP-3 ratio (-2.04 +/- 1.2 vs. 0.92 +/- 1.22, p = 0.081) in athletes with FHA compared with EUM athletes. Furthermore, there was a non-significant trend toward a higher increase in prolactin to cortisol ratio in EUM athletes compared with athletes with FHA (0.60 +/- 0.15 vs. 0.23 +/- 0.15, p = 0.071). No differences in the hormonal or BDNF responses between the two exercise bouts as a result of menstrual function were found. Conclusion: No major differences in the hormonal or BDNF responses between the two exercise bouts as a result of menstrual function could be detected.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2019. Vol. 10, p. 1-8, article id 942
Keywords [en]
amenorrhea, energy availability, overtraining syndrome, female athlete, brain derived neuronal factor
National Category
Sport and Fitness Sciences
Research subject
Social Sciences, Sport Science
Identifiers
URN: urn:nbn:se:lnu:diva-88797DOI: 10.3389/fphys.2019.00942ISI: 000478027900001PubMedID: 31417414OAI: oai:DiVA.org:lnu-88797DiVA, id: diva2:1346541
Available from: 2019-08-28 Created: 2019-08-28 Last updated: 2019-08-28Bibliographically approved

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Melin, Anna K.

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