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Celiac disease and complement activation in response to Streptococcus pneumoniae
Region Kalmar, Sweden;Örebro University, Sweden.
Region Kalmar, Sweden.ORCID-id: 0000-0002-1707-2655
Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB). (Linnaeus Ctr Biomat Chem, BMC)
Region Kalmar, SwedenRegion Kalmar, Sweden;Linköping University, Sweden.
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2019 (Engelska)Ingår i: European Journal of Pediatrics, ISSN 0340-6199, E-ISSN 1432-1076Artikel i tidskrift (Refereegranskat) Epub ahead of print
Abstract [en]

Individuals with celiac disease (CD) are at increased risk of invasive pneumococcal disease (IPD). The aim of this study was to explore whether the complement response to Streptococcus pneumoniae differed according to CD status, and could serve as an explanation for the excess risk of IPD in CD. Twenty-two children with CD and 18 controls, born 1999-2008, were included at Kalmar County Hospital, Sweden. The degree of complement activation was evaluated by comparing levels of activation products C3a and sC5b-9 in plasma incubated for 30 min with Streptococcus pneumoniae and in non-incubated plasma. Complement analyses were performed with enzyme-linked immunosorbent assay (ELISA). Pneumococcal stimulation caused a statistically significant increase in C3a as well as sC5b-9 in both children with CD and controls but there was no difference in response between the groups. After incubation, C3a increased on average 4.6 times and sC5b-9 22 times in both the CD and the control group (p = 0.497 and p = 0.724 respectively). Conclusion: Complement response to Streptococcus pneumoniae seems to be similar in children with and without CD and is thus unlikely to contribute to the increased susceptibility to invasive pneumococcal disease in CD.

Ort, förlag, år, upplaga, sidor
Springer, 2019.
Nyckelord [en]
Coeliac, Pneumococcal, Infection, Innate immunity, MBL
Nationell ämneskategori
Immunologi
Forskningsämne
Biomedicinsk vetenskap, Immunologi
Identifikatorer
URN: urn:nbn:se:lnu:diva-90197DOI: 10.1007/s00431-019-03490-wISI: 000494392200001PubMedID: 31691001OAI: oai:DiVA.org:lnu-90197DiVA, id: diva2:1371903
Tillgänglig från: 2019-11-21 Skapad: 2019-11-21 Senast uppdaterad: 2019-11-21

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Woksepp, HannaSandholm, KerstinNilsson, Per H.Nilsson Ekdahl, Kristina

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