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Current and Future Approaches for Monitoring Responses to Anti-complement Therapeutics
Univ Penn, USA.
Uppsala University, Sweden.
Uppsala University, Sweden.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (Linnaeus Ctr Biomat Chem, BMC)
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2019 (English)In: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 10, p. 1-13, article id 2539Article, review/survey (Refereed) Published
Abstract [en]

Aberrations in complement system functions have been identified as either direct or indirect pathophysiological mechanisms in many diseases and pathological conditions, such as infections, autoimmune diseases, inflammation, malignancies, and allogeneic transplantation. Currently available techniques to study complement include quantification of (a) individual complement components, (b) complement activation products, and (c) molecular mechanisms/function. An emerging area of major interest in translational studies aims to study and monitor patients on complement regulatory drugs for efficacy as well as adverse events. This area is progressing rapidly with several anti-complement therapeutics under development, in clinical trials, or already in clinical use. In this review, we summarized the appropriate indications, techniques, and interpretations of basic complement analyses, exemplified by a number of clinical disorders.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2019. Vol. 10, p. 1-13, article id 2539
Keywords [en]
clinical trial, laboratory investigation, immunoassays, functional assays, CV%
National Category
Immunology
Research subject
Biomedical Sciences, Immunology
Identifiers
URN: urn:nbn:se:lnu:diva-90506DOI: 10.3389/fimmu.2019.02539ISI: 000498927000001PubMedID: 31787968OAI: oai:DiVA.org:lnu-90506DiVA, id: diva2:1377803
Available from: 2019-12-12 Created: 2019-12-12 Last updated: 2019-12-12Bibliographically approved

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Sandholm, KerstinMohlin, CamillaNilsson Ekdahl, Kristina

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