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Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β-Hydroxyketones
Stockholm University, Sweden.
Stockholm University, Sweden.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.ORCID iD: 0000-0001-7158-6393
Stockholm University, Sweden.ORCID iD: 0000-0001-8462-4176
2021 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 27, no 63, p. 15623-15627Article in journal (Refereed) Published
Abstract [en]

Herein we report on the development and application of chemoenzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) of alpha-substituted beta-hydroxketones (beta-HKs), using Candida antartica lipase B (CALB) as transesterification catalyst and a ruthenium complex as epimerization catalyst. An operationally simple protocol allows for an efficient preparation of highly enantiomerically enriched alpha-substituted beta-oxoacetates. The products were obtained in yields up to 95% with good diastereomeric ratios.

Place, publisher, year, edition, pages
John Wiley & Sons, 2021. Vol. 27, no 63, p. 15623-15627
Keywords [en]
beta-hydroxyketones, DYKAT, lipase, racemization, ruthenium
National Category
Organic Chemistry
Research subject
Chemistry, Organic Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-108086DOI: 10.1002/chem.202102683ISI: 000703579800001PubMedID: 34428339Scopus ID: 2-s2.0-85116331095Local ID: 2021OAI: oai:DiVA.org:lnu-108086DiVA, id: diva2:1612239
Available from: 2021-11-17 Created: 2021-11-17 Last updated: 2022-02-04Bibliographically approved

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Unelius, C. Rikard

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