The purpose of this chapter is to assess and examine the impact health care information technology (HIT) on physician-nurse performance related to patient trust and safety. A considerable number of patients today are using different HITs to get access to healthcare services such as appointment scheduling and medication refills; communicate with physicians and nurses for different computerized tailored interventions to manage a chronic condition or to change a health behavior. Improving the quality and safety of care, and reducing the medical errors are of equal responsibility of all clinicians and all healthcare staff. Patient safety is the most critical factor of the medical and healthcare quality, where nurses can be invaluable in preventing harm to patients, reducing errors and improving patients' outcomes. The chapter shows that there are many advantages of Web-acquired healthcare related information. The main question is how will efficient use of HIT by patients improve healthcare quality, patient trust and safety.