Collections of old human remains in museums are currently under increased scrutiny and pressure. On the one hand they are problematised from a post-colonial and human rights point of view as the material remains of historic and ongoing structural violence connected to scientific knowledge production. On the other, new methods in archaeological science have led to increasing demand for destructive sampling. Without guidance and support by laws and formal standardised professional guidelines, museums may find themselves squeezed from two opposing sides. Based on an analysis of laws and professional guidelines, and a large-scale survey of the practical handling of old human remains in Swedish museums, this article argues that the lack of a shared professional process that recognises the complexity of old human remains as both objects of science and lived lives, risks undermining the role of museums in their relationship to both the public and the research community.