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New paradigms in actomyosin energy transduction: Critical evaluation of non-traditional models for orthophosphate release
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Linnaeus University, Linnaeus Knowledge Environments, Advanced Materials.ORCID iD: 0000-0002-5889-7792
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.ORCID iD: 0000-0001-6662-8886
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.ORCID iD: 0000-0003-3585-5722
McGill Univ, Canada.
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2023 (English)In: Bioessays, ISSN 0265-9247, E-ISSN 1521-1878, Vol. 45, no 9, article id 2300040Article in journal (Refereed) Published
Abstract [en]

Release of the ATP hydrolysis product ortophosphate (Pi) from the active site of myosin is central in chemo-mechanical energy transduction and closely associated with the main force-generating structural change, the power-stroke. Despite intense investigations, the relative timing between Pi-release and the power-stroke remains poorly understood. This hampers in depth understanding of force production by myosin in health and disease and our understanding of myosin-active drugs. Since the 1990s and up to today, models that incorporate the Pi-release either distinctly before or after the power-stroke, in unbranched kinetic schemes, have dominated the literature. However, in recent years, alternative models have emerged to explain apparently contradictory findings. Here, we first compare and critically analyze three influential alternative models proposed previously. These are either characterized by a branched kinetic scheme or by partial uncoupling of Pi-release and the power-stroke. Finally, we suggest critical tests of the models aiming for a unified picture.

Place, publisher, year, edition, pages
John Wiley & Sons, 2023. Vol. 45, no 9, article id 2300040
Keywords [en]
actin, actomyosin, ATP turnover, ATPase, inorganic phosphate, myosin, ortophosphate
National Category
Biochemistry and Molecular Biology
Research subject
Chemistry, Biochemistry
Identifiers
URN: urn:nbn:se:lnu:diva-123551DOI: 10.1002/bies.202300040ISI: 001013725400001PubMedID: 37366639Scopus ID: 2-s2.0-85163000556OAI: oai:DiVA.org:lnu-123551DiVA, id: diva2:1786723
Available from: 2023-08-09 Created: 2023-08-09 Last updated: 2025-02-04Bibliographically approved

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Månsson, AlfUšaj, MarkoMoretto, LuisaVelayuthan, Lok PriyaFriedman, Ran

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