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Expression of the endogenous, nicotinic acetylcholine receptor ligand, SLURP-1, in human colon cancer.
University of Kalmar, School of Pure and Applied Natural Sciences.
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2008 (English)In: Autonomic & Autacoid Pharmacology, ISSN 1474-8665, E-ISSN 1474-8673, Vol. 28, no 4, p. 109-116Article in journal (Refereed) Published
Abstract [en]

1. Secreted mammalian Ly-6/urokinase plasminogen activator receptor-related protein-1 (SLURP-1) is a recently discovered endogenous ligand at the alpha7 subunit of the nicotinic acetylcholine receptors. Previous reports have shown that SLURP-1 is expressed in normal human keratinocytes seemingly with a pro-apoptotic function. Conversely, such expression was markedly attenuated in transformed cells and it was suggested that the molecule could convey protection against malignant transformation. 2. In this study, we demonstrated the mRNA expression (by RT-PCR) and protein expression (by Western blotting and immunocytochemistry) of SLURP-1 in the human colon cancer cell line, HT-29. 3. Furthermore, we demonstrated the expression of SLURP-1 (by immunohistochemistry) in tumour cells of human colon cancer tissue, and, to a greater extent, in immune and smooth muscle cells of adjacent, macroscopically tumour-free colon tissue. 4. The current findings suggest that SLURP-1 participates in the regulation of gut immune functions and motility, as well as possibly playing a role in colon carcinogenesis/cancer progression.

Place, publisher, year, edition, pages
2008. Vol. 28, no 4, p. 109-116
National Category
Medical and Health Sciences
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:hik:diva-2322DOI: 10.1111/j.1474-8673.2008.00424.xOAI: oai:DiVA.org:hik-2322DiVA, id: diva2:274889
Available from: 2009-11-03 Created: 2009-11-02 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Aspects of Non-Neuronal Signalling Functions of Acetylcholine in Colorectal Cancer: Roles for the α7nAChR
Open this publication in new window or tab >>Aspects of Non-Neuronal Signalling Functions of Acetylcholine in Colorectal Cancer: Roles for the α7nAChR
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Kalmar: Högskolan i Kalmar, 2009. p. 60
Series
Dissertation series / University of Kalmar, Faculty of Natural Science, ISSN 1650-2779 ; 76
Keywords
alpha7 nicotinic acetylcholine receptor, acetylcholine, colorectal cancer, morphine, nicotine, plasminogen activator inhibitor-1, SLURP-1
National Category
Cancer and Oncology
Research subject
Natural Science, Biomedical Sciences
Identifiers
urn:nbn:se:hik:diva-2348 (URN)978-91-85993-37-6 (ISBN)
Public defence
2009-09-25, Falkens hörsal (C305), Nygatan 18B, Kalmar, 09:00 (English)
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Supervisors
Available from: 2009-11-04 Created: 2009-11-04 Last updated: 2016-03-11Bibliographically approved

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Pettersson, AnnDelbro, Dick

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