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Nicotine induced modulation of SLURP-1 expression in human colon cancer cells.
University of Kalmar, School of Pure and Applied Natural Sciences.
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2009 (English)In: Autonomic Neuroscience: Basic & Clinical, ISSN 1566-0702, E-ISSN 1872-7484, Vol. 148, no 1-2, p. 97-100Article in journal (Refereed) Published
Abstract [en]

The secreted mammalian Ly-6⁄urokinase plasminogen activator receptor-related protein-1 (SLURP-1) is an endogenous ligand at the α7 subunit of the nicotinic acetylcholine receptor (nAChR). SLURP-1 has anti-tumourigenic properties. In the current study, we demonstrate that the challenge of HT-29 human colon cancer cells with nicotine for 24 h to increase cell growth via the α7nAChRs, caused a marked reduction of the protein expression of SLURP-1. We suggest that there is an interplay between acetylcholine and SLURP-1 in the HT-29 cells, both molecules serving as autocrine growth controlling ligands at the α7nAChR, where acetylcholine regulates the release of SLURP-1.

Place, publisher, year, edition, pages
2009. Vol. 148, no 1-2, p. 97-100
National Category
Medical and Health Sciences
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:hik:diva-2324DOI: 10.1016/j.autneu.2009.03.002OAI: oai:DiVA.org:hik-2324DiVA, id: diva2:274909
Available from: 2009-11-03 Created: 2009-11-02 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Aspects of Non-Neuronal Signalling Functions of Acetylcholine in Colorectal Cancer: Roles for the α7nAChR
Open this publication in new window or tab >>Aspects of Non-Neuronal Signalling Functions of Acetylcholine in Colorectal Cancer: Roles for the α7nAChR
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Kalmar: Högskolan i Kalmar, 2009. p. 60
Series
Dissertation series / University of Kalmar, Faculty of Natural Science, ISSN 1650-2779 ; 76
Keywords
alpha7 nicotinic acetylcholine receptor, acetylcholine, colorectal cancer, morphine, nicotine, plasminogen activator inhibitor-1, SLURP-1
National Category
Cancer and Oncology
Research subject
Natural Science, Biomedical Sciences
Identifiers
urn:nbn:se:hik:diva-2348 (URN)978-91-85993-37-6 (ISBN)
Public defence
2009-09-25, Falkens hörsal (C305), Nygatan 18B, Kalmar, 09:00 (English)
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Available from: 2009-11-04 Created: 2009-11-04 Last updated: 2016-03-11Bibliographically approved

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Pettersson, AnnDelbro, Dick

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