Background/Aim: The aim was to identify subjects with incipientAlzheimer’s disease (AD) among patients with mildcognitive impairment (MCI) using brief cognitive tests. Methods:A total of 147 MCI patients were followed for 4–6 yearsand the incidence of AD was 11.6%/year. At baseline, thecube copying test, clock drawing test, MMSE and measurementsof regional cerebral blood flow (rCBF) and cerebrospinalfluid (CSF) -amyloid 1–42 (A 42 ) were performed. Results:The cube copying test, but not the clock drawing test, couldpredict AD among MCI patients with an area under the receiveroperating characteristic curve of 0.64 (p ! 0.01). Therelative risk for future AD was increased in MCI subjects withimpaired cube copying test (sex- and age-adjusted hazardratio = 1.8, p ! 0.05) and the incidence of AD was 18.2% inthis subgroup. Combining the cube copying test with eitherrCBF or CSF A 4 2 had additive effects on the risk assessmentfor future development of AD. MCI patients achieving highscores on both MMSE and cube copying test had a very lowrisk of developing AD (incidence of AD = 1.6%). Conclusion:In conclusion, combinations of the cube copying test withMMSE, rCBF and CSF A 4 2 measurements can identify subgroupsof MCI subjects with either substantially reduced orincreased risk for future development of AD.