lnu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Platelets, Complement, and Contact Activation: Partners in inflammation and thrombosis
Uppsala University.
Uppsala University.
Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV.ORCID-id: 0000-0002-7192-5794
Uppsala University.
Visa övriga samt affilieringar
2012 (Engelska)Ingår i: Current Topics in Innate Immunity II / [ed] John D. Lambris &George Hajishengallis, Springer, 2012, Vol. 946, nr Current Topics in Innate Immunity II. J. D. Lambris, G. Hajishengallis (eds.), s. 185-205Konferensbidrag, Publicerat paper (Refereegranskat)
Abstract [en]

Platelet activation during thrombotic events is closely associated with complement and contact system activation, which in turn leads to inflammation . Here we review the interactions between activated platelets and the complement and contact activation systems in clotting blood. Chondroitin sulfate A (CS-A), released from alpha granules during platelet activation, is a potent mediator of crosstalk between platelets and the complement system. CS-A activates complement in the fluid phase, generating anaphylatoxins that mediate leukocyte activation. No complement activation seems to occur on the activated platelet surface, but C3 in the form of C3(H2O) is bound to the surfaces of activated platelets . This finding is consistent with the strong expression of membrane-bound complement regulators present at the platelet surface. CS-A exposed on the activated platelets is to a certain amount responsible for recruiting soluble regulators to the surface. Platelet-bound C3(H2O) acts as a ligand for leukocyte CR1 (CD35), potentially enabling platelet–leukocyte interactions. In addition, platelet activation leads to the activation of contact system enzymes, which are specifically inhibited by antithrombin, rather than by C1INH, as is the case when contact activation is induced by material surfaces. Thus, in addition to their traditional role as initiators of secondary hemostasis, platelets also act as mediators and regulators of inflammation in thrombotic events.

Ort, förlag, år, upplaga, sidor
Springer, 2012. Vol. 946, nr Current Topics in Innate Immunity II. J. D. Lambris, G. Hajishengallis (eds.), s. 185-205
Serie
Advances in Experimental Medicine and Biology, ISSN 0065-2598, E-ISSN 2214-8019
Nationell ämneskategori
Immunologi inom det medicinska området
Forskningsämne
Naturvetenskap, Biomedicinsk vetenskap
Identifikatorer
URN: urn:nbn:se:lnu:diva-18990DOI: 10.1007/978-1-4614-0106-3_11ISI: 000335736900012Scopus ID: 2-s2.0-80555154764ISBN: 978-1-4614-0105-6 (tryckt)ISBN: 978-1-4614-0106-3 (digital)OAI: oai:DiVA.org:lnu-18990DiVA, id: diva2:529025
Konferens
7th International Aegean Conference on Innate Immunity, Greece, JUL 04-09, 2010
Tillgänglig från: 2012-05-28 Skapad: 2012-05-28 Senast uppdaterad: 2021-05-06Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextScopus

Person

Nilsson, Per H.Nilsson Ekdahl, Kristina

Sök vidare i DiVA

Av författaren/redaktören
Nilsson, Per H.Nilsson Ekdahl, Kristina
Av organisationen
Institutionen för naturvetenskap, NV
Immunologi inom det medicinska området

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
isbn
urn-nbn

Altmetricpoäng

doi
isbn
urn-nbn
Totalt: 201 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf