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Consequences of morphology on molecularly imprinted polymer-ligand recognition
Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB).
Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB). (PPL;Linnaeus Ctr Biomat Chem, BMC; BBCL)ORCID-id: 0000-0002-7392-0591
Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB). Uppsala University. (Linnaeus Ctr Biomat Chem, BMC;BBCL)ORCID-id: 0000-0002-0407-6542
2013 (engelsk)Inngår i: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 14, nr 1, s. 1207-1217Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The relationship between molecularly imprinted polymer (MIP) morphology and template-rebinding over a series of warfarin-imprinted methacrylic acid co(ethylene dimethacrylate) polymers has been explored. Detailed investigations of the nature of template recognition revealed that an optimal template binding was obtained with polymers possessing a narrow population of pores (~3–4 nm) in the mesopore size range. Importantly, the warfarin-polymer rebinding analyses suggest strategies for regulating ligand binding capacity and specificity through variation of the degree of cross-linking, where polymers prepared with a lower degree of cross-linking afford higher capacity though non-specific in character. In contrast, the co-existence of specific and non-specific binding was found in conjunction with higher degrees of cross-linking and resultant meso- and macropore size distributions.

sted, utgiver, år, opplag, sider
2013. Vol. 14, nr 1, s. 1207-1217
Emneord [en]
molecularly imprinted polymer, MIP, morphology, BET, surface area, warfarin
HSV kategori
Forskningsprogram
Kemi, Organisk kemi
Identifikatorer
URN: urn:nbn:se:lnu:diva-23378DOI: 10.3390/ijms14011207ISI: 000314048800071PubMedID: 23303280Scopus ID: 2-s2.0-84878637249OAI: oai:DiVA.org:lnu-23378DiVA, id: diva2:584772
Tilgjengelig fra: 2013-01-09 Laget: 2013-01-09 Sist oppdatert: 2018-11-02bibliografisk kontrollert

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