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A two-nucleotide deletion renders the mannose-binding lectin 2 (MBL2) gene nonfunctional in Danish Landrace and Duroc pigs
Aarhus Univ.
Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB).
Res & Technol Ctr, Technol & Serv BV, Hendrix Genet Res, Boxmeer, Netherlands.
Res & Technol Ctr, Technol & Serv BV, Hendrix Genet Res, Boxmeer, Netherlands.
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2014 (Engelska)Ingår i: Immunogenetics, ISSN 0093-7711, E-ISSN 1432-1211, Vol. 66, nr 3, s. 171-184Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The mannose-binding lectins (MBLs) are central components of innate immunity, facilitating phagocytosis and inducing the lectin activation pathway of the complement system. Previously, it has been found that certain single-nucleotide polymorphisms (SNPs) in porcine MBL1 and MBL2 (pMBL1, pMBL2) affect mRNA expression, serum concentration, and susceptibility to disease, but the combinatory effect of pMBL1 and pMBL2 genotypes needs further elucidation. In the present study, pMBL1 and pMBL2 alleles, combined pMBL haplotypes, and MBL-A concentration in serum were analyzed in purebred Landrace (N = 30) and Duroc (N = 10) pigs. Furthermore, the combined pMBL haplotypes of 89 PiStrain x (Large White x Landrace) crossbred pigs were studied, and the genotypes of 67 crossbreds challenged with Escherichia coli were compared to their individual disease records. In the purebred animals, three non-synonymous SNPs and a two-nucleotide deletion were detected in the coding sequence of pMBL2. The two-nucleotide deletion was present at a frequency of 0.88 in the Landrace pigs and 0.90 in the Duroc pigs, respectively. In the crossbreds, the T allele of the SNP G949T in pMBL1-previously shown to have profound effect on MBL-A concentration even in the heterozygote condition-was detected in 47 % of the animals. Finally, an association was found between low-producing MBL genotypes and low body weight on the day of weaning in the same animals.

Ort, förlag, år, upplaga, sidor
2014. Vol. 66, nr 3, s. 171-184
Nyckelord [en]
Mannose-binding lectin (MBL), Pigs, Polymorphism, Innate immunity, E. coli, Disease resistance
Nationell ämneskategori
Biokemi och molekylärbiologi
Forskningsämne
Naturvetenskap, Biokemi
Identifikatorer
URN: urn:nbn:se:lnu:diva-33346DOI: 10.1007/s00251-014-0758-5ISI: 000331714200004Scopus ID: 2-s2.0-84894556948OAI: oai:DiVA.org:lnu-33346DiVA, id: diva2:708225
Tillgänglig från: 2014-03-27 Skapad: 2014-03-27 Senast uppdaterad: 2017-12-05Bibliografiskt granskad

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Edman, Kjell

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