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The role and regulation of complement activation as part of the thromboinflammation elicited in cell therapies
Uppsala University.
Uppsala University;University of Tokyo.
Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB). Uppsala University. (Linnaeus Ctr Biomat Chem, BMC)ORCID-id: 0000-0001-7888-1571
2014 (Engelska)Ingår i: Molecular Immunology, ISSN 0161-5890, E-ISSN 1872-9142, Vol. 61, nr 2, s. 185-190Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Cell therapies in which the cells come into direct contact with blood and other body fluids are emerging treatment procedures for patients with various diseases, such as diabetes mellitus, liver insufficiency, and graft-versus-host disease. However, despite recent progress, these procedures are associated with tissue loss caused by thromboinflammatory reactions. These deleterious reactions involve the activation of the complement and coagulation cascades and platelet and leukocyte activation, ultimately resulting in clot formation and damage to the implanted cells. In this concept review, we discuss the basic mechanisms underlying the thrombininflammatory process, with special reference to the engagement of complement and emerging strategies for the therapeutic regulation of these reactions that include the use of selective systemic inhibitors and various procedures to coat the surfaces of the cells. The coating procedures may also be applied to other treatment modalities in which similar mechanisms are involved, including whole organ transplantation, treatment with biomaterials in contact with blood, and extracorporeal procedures. (C) 2014 Published by Elsevier Ltd.

Ort, förlag, år, upplaga, sidor
2014. Vol. 61, nr 2, s. 185-190
Nyckelord [en]
Thromboinflammation, Instant blood-mediated inflammatory reaction (IBMIR), Contact system, Complement, Coagulation, Platelets
Nationell ämneskategori
Immunologi Biokemi och molekylärbiologi
Forskningsämne
Naturvetenskap, Biomedicinsk vetenskap
Identifikatorer
URN: urn:nbn:se:lnu:diva-37912DOI: 10.1016/j.molimm.2014.06.009ISI: 000342265300016Scopus ID: 2-s2.0-84907598129OAI: oai:DiVA.org:lnu-37912DiVA, id: diva2:759634
Tillgänglig från: 2014-10-30 Skapad: 2014-10-30 Senast uppdaterad: 2018-11-16Bibliografiskt granskad

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Nilsson Ekdahl, Kristina

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Molecular Immunology
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