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Complement and platelets: Mutual interference in the immune network
Med Univ Innsbruck, Austria.
Med Univ Innsbruck, Austria.
Med Univ Innsbruck, Austria.
Med Univ Innsbruck, Austria.
Vise andre og tillknytning
2015 (engelsk)Inngår i: Molecular Immunology, ISSN 0161-5890, E-ISSN 1872-9142, Vol. 67, nr 1, s. 108-118Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

In recent years, the view of platelets has changed from mere elements of hemostasis to immunological multitaskers. They are connected in manifold ways to other cellular and humoral components of the immune network, one of which is the complement system, a potent player in soluble innate immunity. Our article reviews the crucial and complex interplay between platelets and complement, focusing on mutual regulation of these two interaction partners by their respective molecular mechanisms. Furthermore, the putative relevance of these processes to infectious diseases, inflammatory conditions, and autoimmune disorders, as well as the treatment of patients with biomaterials is highlighted. (C) 2015 Elsevier Ltd. All rights reserved.

sted, utgiver, år, opplag, sider
2015. Vol. 67, nr 1, s. 108-118
Emneord [en]
Complement, Platelets, Innate immunity, Immune network, Infectious diseases, Autoimmunity and inflammatory disorders, Biomaterials
HSV kategori
Forskningsprogram
Biomedicinsk vetenskap, Immunologi
Identifikatorer
URN: urn:nbn:se:lnu:diva-45771DOI: 10.1016/j.molimm.2015.03.244ISI: 000357144100012PubMedID: 25886718Scopus ID: 2-s2.0-84936986317OAI: oai:DiVA.org:lnu-45771DiVA, id: diva2:847352
Tilgjengelig fra: 2015-08-20 Laget: 2015-08-19 Sist oppdatert: 2018-11-16bibliografisk kontrollert

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