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Carriage of CTX-M type extended spectrum beta-lactamases (ESBLs) in gulls across Europe
Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science. (Ctr Ecol & Evolut Microbial Model Syst EEMiS)
Kalmar County Hospital;Uppsala University.ORCID iD: 0000-0002-3182-389X
Uppsala University.ORCID iD: 0000-0002-5564-305X
Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science. (Ctr Ecol & Evolut Microbial Model Syst EEMiS)ORCID iD: 0000-0002-1152-4235
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2015 (English)In: Acta Veterinaria Scandinavica, ISSN 0044-605X, E-ISSN 1751-0147, Vol. 57, article id 74Article in journal (Refereed) Published
Abstract [en]

Background: Extended spectrum beta-lactamases (ESBLs), a group of enzymes conferring resistance to third generation cephalosporins have rapidly increased in Enterobacteriacae and pose a major challenge to human health care. Resistant isolates are common in domestic animals and clinical settings, but prevalence and genotype distribution varies on a geographical scale. Although ESBL genes are frequently detected in bacteria isolated from wildlife samples, ESBL dissemination of resistant bacteria to the environment is largely unknown. To address this, we used three closely related gull species as a model system and collected more than 3000 faecal samples during breeding times in nine European countries. Samples were screened for ESBL-producing bacteria, which were characterized to the level of ESBL genotype groups (SHV, TEM), or specific genotypes (CTX-M). Results: ESBL-producing bacteria were frequently detected in gulls (906 of 3158 samples, 28.7 %), with significant variation in prevalence rates between countries. Highest levels were found in Spain (74.8 %), The Netherlands (37.8 %) and England (27.1 %). Denmark and Poland represented the other extreme with no, or very few positive samples. Genotyping of CTX-M isolates identified 13 different variants, with bla(CTX-M-1) and bla(CTX-M-14) as the most frequently detected. In samples from England, Spain and Portugal, blaCTX-M-14 dominated, while in the rest of the sampled countries blaCTX-M-1 (except Sweden where bla(CTX-M-15) was dominant) was the most frequently detected genotype, a pattern similar to what is known from studies of human materials. Conclusions: CTX-M type ESBLs are common in the faecal microbiota from gulls across Europe. The gull ESBL genotype distribution was in large similar to published datasets from human and food-production animals in Europe. The data suggests that the environmental dissemination of ESBL is high from anthropogenic sources, and widespread occurrence of resistant bacteria in common migratory bird species utilizing urban and agricultural areas suggests that antibiotic resistance genes may also be spread through birds.

Place, publisher, year, edition, pages
2015. Vol. 57, article id 74
Keywords [en]
ESBL, CTX-M, Wildlife, Birds, Gulls, Antibiotic resistance, E. coli, Europe
National Category
Microbiology Veterinary Science
Research subject
Ecology, Zoonotic Ecology
Identifiers
URN: urn:nbn:se:lnu:diva-47378DOI: 10.1186/s13028-015-0166-3ISI: 000363921100001PubMedID: 26526188Scopus ID: 2-s2.0-84945962826OAI: oai:DiVA.org:lnu-47378DiVA, id: diva2:873568
Available from: 2015-11-24 Created: 2015-11-24 Last updated: 2022-06-07Bibliographically approved
In thesis
1. Wild Birds as Carriers of Antibiotic Resistane E. coli and Extended-Spectrum Beta-Lactamases
Open this publication in new window or tab >>Wild Birds as Carriers of Antibiotic Resistane E. coli and Extended-Spectrum Beta-Lactamases
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Linnaeus University Press, 2014. p. 69
Series
Linnaeus University Dissertations ; 178
National Category
Microbiology
Research subject
Ecology, Microbiology
Identifiers
urn:nbn:se:lnu:diva-110836 (URN)9789187427930 (ISBN)
Public defence
2014-06-13, Fullriggaren, Landgången 4, Kalmar, 09:30 (English)
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Supervisors
Available from: 2022-03-16 Created: 2022-03-16 Last updated: 2025-01-29Bibliographically approved

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Stedt, JohanBonnedahl, JonasHernandez, JorgeWaldenström, JonasTolf, ConnyOlsen, Björn

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