Cyber-Physical Systems (CPS) are large interconnected softwareintensivesystems that influence, by sensing and actuating, thephysical world. Examples are traffic management and power grids.One of the trends we observe is the need to endow such systemswith the “smart” capabilities, typically in the form of selfawarenessand self-adaptation, along with the traditional qualitiesof safety and dependability. These requirements combined withspecifics of the domain of smart CPS – such as large scale, the roleof end-users, uncertainty, and open-endedness – render traditionalsoftware engineering (SE) techniques not directly applicable; makingsystematic SE of smart CPS a challenging task. This paperreports on the results of the First International Workshop on SoftwareEngineering of Smart Cyber-Physical Systems (SEsCPS2015), where participants discussed characteristics, challenges andopportunities of SE for smart CPS, with the aim to outline anagenda for future research in this important area.