lnu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Biological Membranes in Extreme Conditions: Anionic Tetraether Lipid Membranes and Their Interactions with Sodium and Potassium
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (Computational Chemistry and Biochemistry (CCBG) ; LNUC Biomaterials Chemistry)
Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science. (Centre for Ecology and Evolution in Microbial model Systems (EEMiS))ORCID iD: 0000-0002-9622-3318
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (Computational Chemistry and Biochemistry (CCBG) ; LNUC Biomaterials Chemistry)ORCID iD: 0000-0001-8696-3104
2016 (English)In: Journal of Physical Chemistry B, ISSN 1520-6106, E-ISSN 1520-5207, Vol. 120, no 41, 10628-10634 p.Article in journal (Refereed) Published
Abstract [en]

Archaea such as Sulfolobus acidocaldarius tolerate extreme temperatures and high acidity and can grow in the presence of toxic metals and low concentrations of Na+ or K+. It is believed that their unique tetraether membranes protect them from harsh environments and allow their survival under such conditions. We used molecular dynamics simulations to study membranes comprising glycerol dialkylnonitol tetraether lipids, which are the main component of S. acidocaldariusmembranes, in solutions containing different concentrations of NaCl and KCl or with Na+ or K+counterions (trace cations, 0 M). Anionic binding sites on the membranes were almost 50% occupied in the presence of counterions. The free energy of cation–phosphate complexation and the residence times of ions near the membranes were found to be both ion- and concentration-dependent. Sodium ions had more favorable interactions with the membranes and a longer residence time, whereas higher cation concentrations led to shorter ion residence times. When only counterions were present in the solutions, large residence times suggested that the membrane may function as a cation-attracting reservoir. The results suggested that the ions can be easily transferred to the cytoplasm as needed, explaining the growth curves of S. acidocaldarius under different salinities and pH.

Place, publisher, year, edition, pages
2016. Vol. 120, no 41, 10628-10634 p.
National Category
Theoretical Chemistry Physical Chemistry
Research subject
Chemistry, Physical Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-57493DOI: 10.1021/acs.jpcb.6b06206ISI: 000386107500002OAI: oai:DiVA.org:lnu-57493DiVA: diva2:1038867
Funder
Carl Tryggers foundation , 11:146Carl Tryggers foundation , 12:140Swedish National Infrastructure for Computing (SNIC)
Available from: 2016-10-20 Created: 2016-10-20 Last updated: 2016-11-18Bibliographically approved

Open Access in DiVA

The full text will be freely available from 2017-10-26 10:54
Available from 2017-10-26 10:54

Other links

Publisher's full text

Search in DiVA

By author/editor
Pineda De Castro, Luis FelipeDopson, MarkFriedman, Ran
By organisation
Department of Chemistry and Biomedical SciencesDepartment of Biology and Environmental Science
In the same journal
Journal of Physical Chemistry B
Theoretical ChemistryPhysical Chemistry

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 85 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf