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Modeling the dispersion effects of contractile fibers in smooth muscles
Royal Institute of Technology, (KTH).
Royal Institute of Technology, (KTH).
Graz University of Technology, Austria ; Royal Institute of Technology (KTH).
2010 (English)In: Journal of the mechanics and physics of solids, ISSN 0022-5096, E-ISSN 1873-4782, Vol. 58, no 12, 2065-2082 p.Article in journal (Refereed) Published
Abstract [en]

Micro-structurally based models for smooth muscle contraction are crucial for a better understanding of pathological conditions such as atherosclerosis, incontinence and asthma. It is meaningful that models consider the underlying mechanical structure and the biochemical activation. Hence, a simple mechanochemical model is proposed that includes the dispersion of the orientation of smooth muscle myofilaments and that is capable to capture available experimental data on smooth muscle contraction. This allows a refined study of the effects of myofilament dispersion on the smooth muscle contraction. A classical biochemical model is used to describe the cross-bridge interactions with the thin filament in smooth muscles in which calcium-dependent myosin phosphorylation is the only regulatory mechanism. A novel mechanical model considers the dispersion of the contractile fiber orientations in smooth muscle cells by means of a strain-energy function in terms of one dispersion parameter. All model parameters have a biophysical meaning and may be estimated through comparisons with experimental data. The contraction of the middle layer of a carotid artery is studied numerically. Using a tube the relationships between the internal pressure and the stretches are investigated as functions of the dispersion parameter, which implies a strong influence of the orientation of smooth muscle myofilaments on the contraction response. It is straightforward to implement this model in a finite element code to better analyze more complex boundary-value problems.

Place, publisher, year, edition, pages
2010. Vol. 58, no 12, 2065-2082 p.
National Category
Other Medical Engineering
Research subject
Technology (byts ev till Engineering), Mechanical Engineering
Identifiers
URN: urn:nbn:se:lnu:diva-58903DOI: 10.1016/j.jmps.2010.09.003OAI: oai:DiVA.org:lnu-58903DiVA: diva2:1054996
Available from: 2016-12-09 Created: 2016-12-09 Last updated: 2016-12-16Bibliographically approved

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Kroon, Martin
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CiteExportLink to record
Permanent link

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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
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