lnu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Cell contraction of an elastic substrate assessed by an axisymmetric model
Royal Institute of Technology, (KTH).
2012 (English)In: International Journal of Experimental and Computational Biomechanics, ISSN 1755-8735, Vol. 2, no 1, p. 61-73Article in journal (Refereed) Published
Abstract [en]

In the present paper, a computational model for cell contraction of an elastic substrate is proposed. Axisymmetry is assumed and the cell is represented by its contractile apparatus, which is taken to consist of radially oriented stress fibres. The constitutive behaviour of the contractile apparatus is modelled by use of a strain energy function, and contraction of stress fibres is modelled by giving them a different natural configuration compared with the underlying elastic substrate. The model was compared with experiments, in which fibroblasts were put on an elastic substrate. The contracted cell radius depends on the stiffness of the elastic substrate, and model predictions were compared with the experimental results for different values of the stiffness of the elastic substrate. The model also predicts that the contraction of the cell tends to cause a small crater below the cell, which is qualitatively in agreement with experimental observations.

Place, publisher, year, edition, pages
2012. Vol. 2, no 1, p. 61-73
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:lnu:diva-58912DOI: 10.1504/IJECB.2012.049780OAI: oai:DiVA.org:lnu-58912DiVA, id: diva2:1055005
Available from: 2016-12-09 Created: 2016-12-09 Last updated: 2016-12-16Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text

Authority records BETA

Kroon, Martin

Search in DiVA

By author/editor
Kroon, Martin
Other Medical Engineering

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 27 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf